Design, synthesis and structure–activity relationships of novel biarylamine-based Met kinase inhibitors by Williams, David K., Chen, Xiao-Tao, Tarby, Christine, Kaltenbach, Robert, Cai, Zhen-Wei, Tokarski, John S., An, Yongmi, Sack, John S., Wautlet, Barri, Gullo-Brown, Johnni, Henley, Benjamin J., Jeyaseelan, Robert, Kellar, Kristen, Manne, Veeraswamy, Trainor, George L., Lombardo, Louis J., Fargnoli, Joseph, Borzilleri, Robert M.

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Discovery and Evaluation of N-Cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a Selective and Orally Efficacious Inhibitor of V... by Borzilleri, Robert M, Bhide, Rajeev S, Barrish, Joel C, D'Arienzo, Celia J, Derbin, George M, Fargnoli, Joseph, Hunt, John T, Jeyaseelan, Robert, Kamath, Amrita, Kukral, Daniel W, Marathe, Punit, Mortillo, Steve, Qian, Ligang, Tokarski, John S, Wautlet, Barri S, Zheng, Xiaoping, Lombardo, Louis J

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Synthesis, SAR, and Evaluation of 4-[2,4-Difluoro-5-(cyclopropylcarbamoyl)phenylamino]pyrrolo[2,1- f][1,2,4]triazine-based VEGFR-2 kinase inhibitors by Cai, Zhen-wei, Wei, Donna, Borzilleri, Robert M., Qian, Ligang, Kamath, Amrita, Mortillo, Steven, Wautlet, Barri, Henley, Benjamin J., Jeyaseelan, Robert, Tokarski, John, Hunt, John T., Bhide, Rajeev S., Fargnoli, Joseph, Lombardo, Louis J.

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Temporal Differences in the Activation of Three Classes of Non- Transmembrane Protein Tyrosine Kinases Following B-Cell Antigen Receptor Surface Engagement by Saouaf, Sandra J., Mahajan, Sandeep, Rowley, R. Bruce, Kut, Stephanie A., Fargnoli, Joseph, Burkhardt, Anne L., Tsukada, Satoshi, Witte, Owen N., Bolden, Joseph B.

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Abstract B192: Preclinical characterization of BMS-833923 (XL139), a hedgehog (HH) pathway inhibitor in early clinical development by Gendreau, Steven B., Hawkins, Don, Ho, Ching-Ping, Lewin, Anne, Lin, Tara, Merchant, Akil, Rowley, R. Bruce, Wang, Qiuju, Matsui, William, Fargnoli, Joseph

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Synthesis and SAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1- f][1,2,4]triazine based VEGFR-2 kinase inhibitors by Borzilleri, Robert M., Cai, Zhen-wei, Ellis, Christopher, Fargnoli, Joseph, Fura, Aberra, Gerhardt, Tracy, Goyal, Bindu, Hunt, John T., Mortillo, Steven, Qian, Ligang, Tokarski, John, Vyas, Viral, Wautlet, Barri, Zheng, Xioping, Bhide, Rajeev S.

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Abstract C18: Assessment of Gli1 expression during skin regeneration in mouse models and normal healthy volunteers by Wang, Xi-De, Rowley, Bruce, Li, Hewei, Lang, Lixin, Zhan, Ping, Lewin, Anne, Hawken, Donald, Ho, Ching-Ping, Huang, Fei, Fargnoli, Joseph, Alhers, Christoph, Alland, Leila, Van Tornout, Jan M., Bennett, Kelly

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Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)- N-(2-methyl-1 H-pyrrolo[2,3- b]pyridin-5-yl)pyrrolo[2,1- f][1,2,4]triazin-4-amine (BMS-645737),... by Ruel, Réjean, Thibeault, Carl, L’Heureux, Alexandre, Martel, Alain, Cai, Zhen-Wei, Wei, Donna, Qian, Ligang, Barrish, Joel C., Mathur, Arvind, D’Arienzo, Celia, Hunt, John T., Kamath, Amrita, Marathe, Punit, Zhang, Yueping, Derbin, George, Wautlet, Barri, Mortillo, Steven, Jeyaseelan, Robert, Henley, Benjamin, Tejwani, Ravindra, Bhide, Rajeev S., Trainor, George L., Fargnoli, Joseph, Lombardo, Louis J.

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Discovery and Preclinical Evaluation of [4-[[1-(3-fluorophenyl)methyl]-1 H -indazol-5-ylamino]-5-methylpyrrolo[2,1- f ][1,2,4]triazin-6-yl]carbamic Acid, (3 S )-3-Morpholinylmethyl... by Gavai, Ashvinikumar V., Fink, Brian E., Fairfax, David J., Martin, Gregory S., Rossiter, Lana M., Holst, Christian L., Kim, Soong-Hoon, Leavitt, Kenneth J., Mastalerz, Harold, Han, Wen-Ching, Norris, Derek, Goyal, Bindu, Swaminathan, Shankar, Patel, Bharat, Mathur, Arvind, Vyas, Dolatrai M., Tokarski, John S., Yu, Chiang, Oppenheimer, Simone, Zhang, Hongjian, Marathe, Punit, Fargnoli, Joseph, Lee, Francis Y., Wong, Tai W., Vite, Gregory D.

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The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2 by Bell, G M, Fargnoli, J, Bolen, J B, Kish, L, Imboden, J B

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Discordant expression of heat shock protein mRNAs in tissues of heat-stressed rats by BLAKE, M. J, GERSHON, D, PARGNOLI, J, HOLBROOK, N. J

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Brivanib Alaninate, a Dual Inhibitor of Vascular Endothelial Growth Factor Receptor and Fibroblast Growth Factor ReceptorTyrosine Kinases, Induces Growth Inhibition in Mouse Models... by HUYNH, Hung, VAN CHANH NGO, POLLOCK, Pamela, BYRON, Sara, TRAN, Evelyn, FARGNOLI, Joseph, AYERS, Mark, KHEE CHEE SOO, HENG NUNG KOONG, CHOON HUA THNG, HOCK SOO ONG, CHUNG, Alexander, CHOW, Pierce

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Ctk: A Protein-Tyrosine Kinase Related to Csk that Defines an Enzyme Family by Klages, Sabine, Adam, Dieter, Class, Kenneth, Fargnoli, Joseph, Bolen, Joseph B., Penhallow, Robert C.

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Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement by Burkhardt, A L, Stealey, B, Rowley, R B, Mahajan, S, Prendergast, M, Fargnoli, J, Bolen, J B

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Synthesis, SAR, and Evaluation of 4-[2,4-Difluoro-5- (cyclopropylcarbamoyl)phenylamino]pyrrolo[2,1-f][1,2,4]triazine-ba sed VEGFR-2 kinase inhibitors by Cai, Zhen-Wei, Wei, Donna, Borzilleri, Robert M, Qian, Ligang, Kamath, Amrita, Mortillo, Steven, Wautlet, Barri, Henley, Benjamin J, Sr., Robert Jeyaseelan, Tokarski, John, Hunt, John T, Bhide, Rajeev S, Fargnoli, Joseph, Lombardo, Louis J

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Discovery of Brivanib Alaninate (S)-(R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl2-aminopropanoate, A Novel Prodrug of Dual... by CAI, Zhen-Wei, YONGZHENG ZHANG, WAUTLET, Barri S, MORTILLO, Steve, JEYASEELAN, Robert, KUKRAL, Daniel W, KAMATH, Amrita, MARATHE, Punit, D'ARIENZO, Celia, DERBIN, George, BARRISH, Joel C, ROBL, Jeffrey A, BORZILLERI, Robert M, HUNT, John T, LOMBARDO, Louis J, FARGNOLI, Joseph, BHIDE, Rajeev S, LIGANG QIAN, BARBOSA, Stephanie, WEI, Donna, XIAOPING ZHENG, WU, Lawrence, JUNYING FAN, ZHONGPING SHI

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Decreased Expression of Heat Shock Protein 70 mRNA and Protein after Heat Treatment in Cells of Aged Rats by Fargnoli, Joseph, Kunisada, Takahiro, Fornace, Albert J., Schneider, Edward L., Holbrook, Nikki J.

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Discovery and evaluation of N-cyclopropyl-2,4-difluoro-5-(2-(pyridin-2-ylamino)thiazol-5-ylmethyl)aminobenzamide (BMS-605541), a selective and orally efficacious inhibitor of vascu... by BORZILLERI, Robert M, BHIDE, Rajeev S, MARATHE, Punit, MORTILLO, Steve, LIGANG QIAN, TOKARSKI, John S, WAUTLET, Barri S, XIAOPING ZHENG, LOMBARDO, Louis J, BARRISH, Joel C, D'ARIENZO, Celia J, DERBIN, George M, FARGNOLI, Joseph, HUNT, John T, JEYASEELAN, Robert, KAMATH, Amrita, KUKRAL, Daniel W

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Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl- 1H-indol-5-yloxy)-5-methylpyrrolo[2,1-/][1,2,4]triazin-6-yloxy)propan2-ol (BMS-540215), an in vivo active potent V... by BHIDE, Rajeev S, CAI, Zhen-Wei, BARRISH, Joel C, KIM, Soong-Hoon, LEAVITT, Kenneth, MATHUR, Arvind, LEITH, Leslie, CHAO, Sam, WAUTLET, Barri, MORTILLO, Steven, JEYASEELAN, Robert, KUKRAL, Daniel, ZHANG, Yong-Zheng, HUNT, John T, KAMATH, Amrita, FURA, Aberra, VYAS, Viral, MARATHE, Punit, D'ARIENZO, Celia, DERBIN, George, FARGNOLI, Joseph, LIGANG QIAN, WEI, Donna, BARBOSA, Stephanie, LOMBARDO, Louis J, BORZILLERI, Robert M, XIAOPING ZHENG, WU, Laurence I

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Isolation and characterization of the hamster gadd153 gene. Activation of promoter activity by agents that damage DNA by Luethy, J D, Fargnoli, J, Park, J S, Fornace, A J, Holbrook, N J

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