Mechanism of action of a nanomolar potent, allosteric antagonist of the thyroid‐stimulating hormone receptor by van Koppen, Chris J, de Gooyer, Marcel E, Karstens, Willem‐Jan, Plate, Ralf, Conti, Paolo GM, van Achterberg, Tanja AE, van Amstel, Monique GA, Brands, Jolanda HGM, Wat, Jesse, Berg, Rob JW, Lane, J Robert D, Miltenburg, Andre MM, Timmers, C Marco

Get full text

Signaling of an allosteric, nanomolar potent, low molecular weight agonist for the follicle-stimulating hormone receptor by van Koppen, Chris J., Verbost, Pieter M., van de Lagemaat, Ruud, Karstens, Willem-Jan F., Loozen, Huub J.J., van Achterberg, Tanja A.E., van Amstel, Monique G.A., Brands, Jolanda H.G.M., van Doornmalen, Els J.P., Wat, Jesse, Mulder, Saskia J., Raafs, Bianca C., Verkaik, Saskia, Hanssen, Rob G.J.M., Timmers, C. Marco

Get full text

Complete Inhibition of rhTSH-, Graves' Disease IgG-, and M22-Induced cAMP Production in Differentiated Orbital Fibroblasts by a Low-Molecular-Weight TSHR Antagonist by van Zeijl, Clementine J. J, van Koppen, Chris J, Surovtseva, Olga V, de Gooyer, Marcel E, Plate, Ralf, Conti, Paolo, Karstens, Willem-Jan, Timmers, Marco, Saeed, Peerooz, Wiersinga, Wilmar M, Miltenburg, André M. M, Fliers, Eric, Boelen, Anita

Get full text

Identification of Substituted 6-Amino-4-phenyltetrahydroquinoline Derivatives:  Potent Antagonists for the Follicle-Stimulating Hormone Receptor by van Straten, Nicole C. R, van Berkel, Twan H. J, Demont, Dennis R, Karstens, Willem-Jan F, Merkx, Remco, Oosterom, Julia, Schulz, Jürgen, van Someren, Richard G, Timmers, Cornelis M, van Zandvoort, Peter M

Get full text

Multidimensional Profiling of CSF1R Screening Hits and Inhibitors: Assessing Cellular Activity, Target Residence Time, and Selectivity in a Higher Throughput Way by Uitdehaag, Joost C.M., Sünnen, Cecile M., van Doornmalen, Antoon M., de Rouw, Nikki, Oubrie, Arthur, Azevedo, Rita, Ziebell, Michael, Nickbarg, Elliott, Karstens, Willem-Jan, Ruygrok, Simone

Get full text

Water Structural Changes at the Proton Uptake Site (the Thr46-Asp96 Domain) in the L Intermediate of Bacteriorhodopsin by Yamazaki, Yoichi, Hatanaka, Minoru, Kandori, Hideki, Sasaki, Jun, Karstens, Willem F. Jan, Raap, Jan, Lugtenburg, Johan, Bizounok, Marina, Herzfeld, Judith

Get full text

Discovery of N‑(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases by Zhang, Hongjun, Lapointe, Blair T, Anthony, Neville, Azevedo, Rita, Cals, Jos, Correll, Craig C, Daniels, Matthew, Deshmukh, Sujal, van Eenenaam, Hans, Ferguson, Heidi, Hegde, Laxminarayan G, Karstens, Willem Jan, Maclean, John, Miller, J. Richard, Moy, Lily Y, Simov, Vladimir, Nagpal, Sunil, Oubrie, Arthur, Palte, Rachel L, Parthasarathy, Gopal, Sciammetta, Nunzio, van der Stelt, Mario, Woodhouse, Janice D, Trotter, B. Wesley, Barr, Kenneth

Get full text

Detection of threonine structural changes upon formation of the M-intermediate of bacteriorhodopsin: evidence for assignment to Thr-89 by Liu, Xiaomei, Lee, Min Joo, Coleman, Matthew, Rath, Parshuram, Nilsson, Anders, Fischer, Wolfgang B., Bizounok, Marina, Herzfeld, Judith, Karstens, Willem F.Jan, Raap, Jan, Lugtenburg, Johan, Rothschild, Kenneth J.

Get full text

Food and land system transformations under different societal perspectives on sustainable development by Weindl, Isabelle, Soergel, Bjoern, Ambrósio, Geanderson, Daioglou, Vassilis, Doelman, Jonathan, Beier, Felicitas, Beusen, Arthur, Bodirsky, Benjamin Leon, Bos, Astrid, Dietrich, Jan Philipp, Humpenöder, Florian, von Jeetze, Patrick, Karstens, Kristine, Rauner, Sebastian, Stehfest, Elke, Stevanović, Miodrag, van Zeist, Willem-Jan, Lotze-Campen, Hermann, van Vuuren, Detlef, Kriegler, Elmar, Popp, Alexander

Get full text

Achievements in colorectal cancer care during 8 years of auditing in The Netherlands by de Neree tot Babberich, Michael P.M., Detering, Robin, Dekker, Jan Willem T., Elferink, Marloes A., Tollenaar, Rob A.E.M., Wouters, Michel W.J.M., Tanis, Pieter J., Beets-Tan, R.G.H., Bemelman, W.A., Boerma, D., Coenen, P.P., Dekker, E., Eddes, E.H., Gelderblom, H., van der Harst, E., Karsten, T.M., van Krieken, J.H., van Leersum, N.J., Lemmens, V.E., Meijerink, W.J., Manusama, E.R., Marijnen, C.A.M., Nagtegaal, I.D., van de Velde, C.J., Wiggers, T.

Get full text

Nationwide analysis of hospital variation in preoperative radiotherapy use for rectal cancer following guideline revision by Detering, Robin, de Neree tot Babberich, Michael P.M., Bos, Amanda C.R.K., Dekker, Jan Willem T., Wouters, Michel W.J.M., Bemelman, Willem A., Beets-Tan, Regina G.H., Marijnen, Corrie A.M., Hompes, Roel, Tanis, Pieter J., Aalbers, A.G.J., den Boer, F.C., Breukink, S., Coene, P.P.L.O., Doornebosch, P.G., Gelderblom, H., Karsten, T.M., Ledeboer, M., Manusama, E.R., Nagtegaal, I.D., Peeters, K.C.M.J., Tollenaar, R.A.E.M., van de Velde, C.J.H., Wagner, A., Westerterp, M., van Westreenen, H.L.

Get full text