Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 1 by Dwyer, Michael P., Paruch, Kamil, Labroli, Marc, Alvarez, Carmen, Keertikar, Kerry M., Poker, Cory, Rossman, Randall, Fischmann, Thierry O., Duca, Jose S., Madison, Vincent, Parry, David, Davis, Nicole, Seghezzi, Wolfgang, Wiswell, Derek, Guzi, Timothy J.

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Substituted tetracyclic indole core derivatives of HCV NS5A inhibitor MK-8742 by Yu, Wensheng, Zhou, Guowei, Coburn, Craig A., Zeng, Qingbei, Tong, Ling, Dwyer, Michael P., Hu, Bin, Zhong, Bin, Hao, Jinglai, Ji, Tao, Zan, Shuai, Chen, Lei, Mazzola, Robert, Kim, Jae-Hun, Sha, Deyou, Selyutin, Oleg, Rosenblum, Stuart B., Lavey, Brian, Nair, Anilkumar G., Heon Kim, Seong, Keertikar, Kerry M., Rokosz, Laura, Agrawal, Sony, Liu, Rong, Xia, Ellen, Zhai, Ying, Curry, Stephanie, McMonagle, Patricia, Ingravallo, Paul, Asante-Appiah, Ernest, Chen, Shiying, Kozlowski, Joseph A.

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Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors by Dwyer, Michael P., Keertikar, Kerry M., Chen, Lei, Tong, Ling, Selyutin, Oleg, Nair, Anilkumar G., Yu, Wensheng, Zhou, Guowei, Lavey, Brian J., Yang, De-Yi, Wong, Michael, Kim, Seong Heon, Coburn, Craig A., Rosenblum, Stuart B., Zeng, Qingbei, Jiang, Yueheng, Shankar, Bandarpalle B., Rizvi, Razia, Nomeir, Amin A., Liu, Rong, Agrawal, Sony, Xia, Ellen, Kong, Rong, Zhai, Ying, Ingravallo, Paul, Asante-Appiah, Ernest, Kozlowski, Joseph A.

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The application of ( Z)-3-aryl-3-haloenoic acids to the synthesis of ( Z)-5-benzylidene-4-arylpyrrol-2(5 H)-ones by Gupton, John T., Telang, Nakul, Banner, Edith J., Kluball, Emily J., Hall, Kayleigh E., Finzel, Kara L., Jia, Xin, Bates, Spencer R., Welden, R. Scott, Giglio, Benjamin C., Eaton, James E., Barelli, Peter J., Firich, Lauren T., Stafford, John A., Coppock, Matthew B., Worrall, Eric F., Kanters, Rene P.F., Keertikar, Kerry, Osterman, Rebecca

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A convergent preparation of the CHK1 inhibitor MK-8776 (SCH 900776) by Labroli, Marc A., Dwyer, Michael P., Poker, Cory, Keertikar, Kerry M., Rossman, Randall, Guzi, Timothy J.

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MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV by Nair, Anilkumar G., Zeng, Qingbei, Selyutin, Oleg, Rosenblum, Stuart B., Jiang, Yueheng, Yang, De-Yi, Keertikar, Kerry, Zhou, Guowei, Dwyer, Michael, Kim, Seong Heon, Shankar, Bandarpalle, Yu, Wensheng, Tong, Ling, Chen, Lei, Mazzola, Robert, Caldwell, John, Tang, Haiqun, Agrawal, Sony, Liu, Rong, Kong, Rong, Ingravallo, Paul, Xia, Ellen, Zhai, Ying, Nomeir, Amin, Asante-Appiah, Ernest, Kozlowski, Joseph A.

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Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development by Nair, Anilkumar G., Zeng, Qingbei, Selyutin, Oleg, Rosenblum, Stuart B., Jiang, Yueheng, Yang, De-Yi, Keertikar, Kerry, Zhou, Guowei, Dwyer, Michael P., Kim, Seong Heon, Shankar, Bandarpalle, Yu, Wensheng, Tong, Ling, Chen, Lei, Mazzola, Robert, Caldwell, John, Tang, Haiqun, Allard, Melissa L., Buckle, Ronald N., Gauuan, Polivina Jolicia F., Holst, Christian L., Martin, Gregory S., Naicker, Kannan P., Vellekoop, Samuel, Agrawal, Sony, Liu, Rong, Kong, Rong, Ingravallo, Paul, Xia, Ellen, Zhai, Ying, Nomeir, Amin, Kozlowski, Joseph A.

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Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases by Paruch, Kamil, Dwyer, Michael P, Alvarez, Carmen, Brown, Courtney, Chan, Tin-Yau, Doll, Ronald J, Keertikar, Kerry, Knutson, Chad, McKittrick, Brian, Rivera, Jocelyn, Rossman, Randall, Tucker, Greg, Fischmann, Thierry, Hruza, Alan, Madison, Vincent, Nomeir, Amin A, Wang, Yaolin, Kirschmeier, Paul, Lees, Emma, Parry, David, Sgambellone, Nicole, Seghezzi, Wolfgang, Schultz, Lesley, Shanahan, Frances, Wiswell, Derek, Xu, Xiaoying, Zhou, Quiao, James, Ray A, Paradkar, Vidyadhar M, Park, Haengsoon, Rokosz, Laura R, Stauffer, Tara M, Guzi, Timothy J

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Pyrazolo[1,5- a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2 by Paruch, Kamil, Dwyer, Michael P., Alvarez, Carmen, Brown, Courtney, Chan, Tin-Yau, Doll, Ronald J., Keertikar, Kerry, Knutson, Chad, McKittrick, Brian, Rivera, Jocelyn, Rossman, Randall, Tucker, Greg, Fischmann, Thierry O., Hruza, Alan, Madison, Vincent, Nomeir, Amin A., Wang, Yaolin, Lees, Emma, Parry, David, Sgambellone, Nicole, Seghezzi, Wolfgang, Schultz, Lesley, Shanahan, Fran, Wiswell, Derek, Xu, Xiaoying, Zhou, Quiao, James, Ray A., Paradkar, Vidyadhar M., Park, Haengsoon, Rokosz, Laura R., Stauffer, Tara M., Guzi, Timothy J.

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Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors by Dwyer, Michael P., Paruch, Kamil, Alvarez, Carmen, Doll, Ronald J., Keertikar, Kerry, Duca, Jose, Fischmann, Thierry O., Hruza, Alan, Madison, Vincent, Lees, Emma, Parry, David, Seghezzi, Wolfgang, Sgambellone, Nicole, Shanahan, Frances, Wiswell, Derek, Guzi, Timothy J.

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