The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL by Jacobsen, Annette V., Pierotti, Catia L., Lowes, Kym N., Au, Amanda E., Zhang, Ying, Etemadi, Nima, Fitzgibbon, Cheree, Kersten, Wilhelmus J. A., Samson, André L., van Delft, Mark F., Huang, David C. S., Sabroux, Hélène Jousset, Lessene, Guillaume, Silke, John, Murphy, James M.

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Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis by Petrie, Emma J., Sandow, Jarrod J., Jacobsen, Annette V., Smith, Brian J., Griffin, Michael D. W., Lucet, Isabelle S., Dai, Weiwen, Young, Samuel N., Tanzer, Maria C., Wardak, Ahmad, Liang, Lung-Yu, Cowan, Angus D., Hildebrand, Joanne M., Kersten, Wilhelmus J. A., Lessene, Guillaume, Silke, John, Czabotar, Peter E., Webb, Andrew I., Murphy, James M.

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Characterization of the Novel Broad-Spectrum Kinase Inhibitor CTx-0294885 As an Affinity Reagent for Mass Spectrometry-Based Kinome Profiling by Zhang, Luxi, Holmes, Ian P, Hochgräfe, Falko, Walker, Scott R, Ali, Naveid A, Humphrey, Emily S, Wu, Jianmin, de Silva, Melanie, Kersten, Wilhelmus J. A, Connor, Theresa, Falk, Hendrik, Allan, Lynda, Street, Ian P, Bentley, John D, Pilling, Patricia A, Monahan, Brendon J, Peat, Thomas S, Daly, Roger J

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Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity by Sleebs, Brad E, Czabotar, Peter E, Fairbrother, Wayne J, Fairlie, W. Douglas, Flygare, John A, Huang, David C. S, Kersten, Wilhelmus J. A, Koehler, Michael F. T, Lessene, Guillaume, Lowes, Kym, Parisot, John P, Smith, Brian J, Smith, Morey L, Souers, Andrew J, Street, Ian P, Yang, Hong, Baell, Jonathan B

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Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3 by Petrie, Emma J., Sandow, Jarrod J., Lehmann, Wil I.L., Liang, Lung-Yu, Coursier, Diane, Young, Samuel N., Kersten, Wilhelmus J.A., Fitzgibbon, Cheree, Samson, André L., Jacobsen, Annette V., Lowes, Kym N., Au, Amanda E., Jousset Sabroux, Hélène, Lalaoui, Najoua, Webb, Andrew I., Lessene, Guillaume, Manning, Gerard, Lucet, Isabelle S., Murphy, James M.

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Structure-Guided Rescaffolding of Selective Antagonists of BCL‑XL by Koehler, Michael F. T, Bergeron, Philippe, Choo, Edna F, Lau, Kevin, Ndubaku, Chudi, Dudley, Danette, Gibbons, Paul, Sleebs, Brad E, Rye, Carl S, Nikolakopoulos, George, Bui, Chinh, Kulasegaram, Sanji, Kersten, Wilhelmus J. A, Smith, Brian J, Czabotar, Peter E, Colman, Peter M, Huang, David C. S, Baell, Jonathan B, Watson, Keith G, Hasvold, Lisa, Tao, Zhi-Fu, Wang, Le, Souers, Andrew J, Elmore, Steven W, Flygare, John A, Fairbrother, Wayne J, Lessene, Guillaume

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Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway by Pierotti, Catia L., Tanzer, Maria C., Jacobsen, Annette V., Hildebrand, Joanne M., Garnier, Jean-Marc, Sharma, Pooja, Lucet, Isabelle S., Cowan, Angus D., Kersten, Wilhelmus J. A., Luo, Meng-Xiao, Liang, Lung-Yu, Fitzgibbon, Cheree, Garnish, Sarah E., Hempel, Anne, Nachbur, Ueli, Huang, David C. S., Czabotar, Peter E., Silke, John, van Delft, Mark F., Murphy, James M., Lessene, Guillaume

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Structure-Guided Rescaffolding of Selective Antagonists of BCL-X L by Koehler, Michael F. T., Bergeron, Philippe, Choo, Edna F., Lau, Kevin, Ndubaku, Chudi, Dudley, Danette, Gibbons, Paul, Sleebs, Brad E., Rye, Carl S., Nikolakopoulos, George, Bui, Chinh, Kulasegaram, Sanji, Kersten, Wilhelmus J. A., Smith, Brian J., Czabotar, Peter E., Colman, Peter M., Huang, David C. S., Baell, Jonathan B., Watson, Keith G., Hasvold, Lisa, Tao, Zhi-Fu, Wang, Le, Souers, Andrew J., Elmore, Steven W., Flygare, John A., Fairbrother, Wayne J., Lessene, Guillaume

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Abstract 5371: PRMT5 inhibitors as novel treatment for cancers by Falk, Hendrik, Foitzik, Richard C., Allan, Elizabeth, deSilva, Melanie, Yang, Hong, Bozikis, Ylva E., Nikac, Marica, Walker, Scott R., Camerino, Michelle A., Morrow, Ben J., Stupple, Alexandra E., Lagiakos, Rachel, Pinson, Jo-Anne, Lessene, Romina, Kersten, Wilhelmus JA, Ganame, Danny G., Holmes, Ian P., Lunniss, Gill E., Chung, Matthew, Hermans, Stefan J., Parker, Michael W., Thistlethwaite, Alison, White, Karen, Charman, Susan A., Monahan, Brendon J., Pilling, Patricia, Grusovin, Julian, Peat, Thomas S., Sonderegger, Stefan, Toulmin, Emma, Jane, Stephen M., Curtis, David J., Stupple, Paul A., Street, Ian P.

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