Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index by Gurtan, Allan, Dominy, John, Khalid, Shareef, Vong, Linh, Caplan, Shari, Currie, Treeve, Richards, Sean, Lamarche, Lindsey, Denning, Daniel, Shpektor, Diana, Gurinovich, Anastasia, Rasheed, Asif, Hameed, Shahid, Saeed, Subhan, Saleem, Imran, Jalal, Anjum, Abbas, Shahid, Sultana, Raffat, Rasheed, Syed Zahed, Memon, Fazal-Ur-Rehman, Shah, Nabi, Ishaq, Mohammad, Khera, Amit V, Danesh, John, Frossard, Philippe, Saleheen, Danish

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ATLANTIS - Attractor Landscape Analysis Toolbox for Cell Fate Discovery and Reprogramming by Shah, Osama Shiraz, Chaudhary, Muhammad Faizyab Ali, Awan, Hira Anees, Fatima, Fizza, Arshad, Zainab, Amina, Bibi, Ahmed, Maria, Hameed, Hadia, Furqan, Muhammad, Khalid, Shareef, Faisal, Amir, Chaudhary, Safee Ullah

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Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure by Henry, Albert, Roselli, Carolina, Sveinbjörnsson, Garðar, Fatemifar, Ghazaleh, Hedman, Åsa K., Morley, Michael P., Helgadottir, Anna, Verweij, Niek, Dehghan, Abbas, Almgren, Peter, Andersson, Charlotte, Backman, Joshua D., Biggs, Mary L., Brandimarto, Jeffrey, Buckbinder, Leonard, Carey, David J., Chasman, Daniel I., Chen, Xu, Chung, Jonathan, Cook, James P., Delgado, Graciela E., Denaxas, Spiros, Dörr, Marcus, Dudley, Samuel C., Esko, Tõnu, Finan, Chris, Gottdiener, John S., Gross, Stefan, Guðbjartsson, Daníel F., Gutmann, Rebecca, Haggerty, Christopher M., Hyde, Craig L., Ingelsson, Erik, Jukema, J. Wouter, Kavousi, Maryam, Khaw, Kay-Tee, Kleber, Marcus E., Køber, Lars, Koekemoer, Andrea, Langenberg, Claudia, Lind, Lars, Lotta, Luca A., Luan, Jian’an, März, Winfried, Melander, Olle, Mordi, Ify R., Morgan, Thomas, Morris, Andrew D., Morris, Andrew P., Morrison, Alanna C., Nelson, Christopher P., Niessner, Alexander, Niiranen, Teemu, O’Donoghue, Michelle L., Owens, Anjali T., Parry, Helen M., Perola, Markus, Rice, Kenneth M., Ridker, Paul M., Rotter, Jerome I., Salo, Perttu, Salomaa, Veikko, Smelser, Diane T., Stender, Steen, Stott, David J., Tammesoo, Mari-Liis, Taylor, Kent D., Teder-Laving, Maris, Thorsteinsdottir, Unnur, Torp-Pedersen, Christian, Trompet, Stella, Tyl, Benoit, Uitterlinden, Andre G., Veluchamy, Abirami, Völker, Uwe, Voors, Adriaan A., Wareham, Nicholas J., Waterworth, Dawn, Weiss, Raul, Wiggins, Kerri L., Yerges-Armstrong, Laura M., Yu, Bing, Zannad, Faiez, Zhao, Jing Hua, Hemingway, Harry, McMurray, John J. V., Yang, Jian, Visscher, Peter M., Malarstig, Anders, Holm, Hilma, Sattar, Naveed, Holmes, Michael V., Cappola, Thomas P., Hingorani, Aroon D., Kuchenbaecker, Karoline, Ellinor, Patrick T., Smith, J. Gustav, Vasan, Ramachandran S., Swerdlow, Daniel I., Lumbers, R. Thomas

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Exome sequencing and characterization of 49,960 individuals in the UK Biobank by Van Hout, Cristopher V., Tachmazidou, Ioanna, Backman, Joshua D., Hoffman, Joshua D., Liu, Daren, Pandey, Ashutosh K., Gonzaga-Jauregui, Claudia, Khalid, Shareef, Ye, Bin, Banerjee, Nilanjana, Li, Alexander H., O’Dushlaine, Colm, Marcketta, Anthony, Staples, Jeffrey, Schurmann, Claudia, Hawes, Alicia, Maxwell, Evan, Barnard, Leland, Lopez, Alexander, Penn, John, Habegger, Lukas, Blumenfeld, Andrew L., Bai, Xiaodong, O’Keeffe, Sean, Yadav, Ashish, Praveen, Kavita, Jones, Marcus, Salerno, William J., Chung, Wendy K., Surakka, Ida, Willer, Cristen J., Hveem, Kristian, Leader, Joseph B., Carey, David J., Ledbetter, David H., Cardon, Lon, Yancopoulos, George D., Economides, Aris, Coppola, Giovanni, Shuldiner, Alan R., Balasubramanian, Suganthi, Cantor, Michael, Nelson, Matthew R., Whittaker, John, Reid, Jeffrey G., Marchini, Jonathan, Overton, John D., Scott, Robert A., Abecasis, Gonçalo R., Yerges-Armstrong, Laura, Baras, Aris

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ALG9 Mutation Carriers Develop Kidney and Liver Cysts by Besse, Whitney, Chang, Alex R, Luo, Jonathan Z, Triffo, William J, Moore, Bryn S, Gulati, Ashima, Hartzel, Dustin N, Mane, Shrikant, Torres, Vicente E, Somlo, Stefan, Mirshahi, Tooraj

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Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals by Kosmicki, Jack A., Horowitz, Julie E., Banerjee, Nilanjana, Lanche, Rouel, Marcketta, Anthony, Maxwell, Evan, Bai, Xiaodong, Sun, Dylan, Backman, Joshua D., Sharma, Deepika, Kury, Fabricio S.P., Kang, Hyun M., O’Dushlaine, Colm, Yadav, Ashish, Mansfield, Adam J., Li, Alexander H., Watanabe, Kyoko, Gurski, Lauren, McCarthy, Shane E., Locke, Adam E., Khalid, Shareef, O’Keeffe, Sean, Mbatchou, Joelle, Chazara, Olympe, Huang, Yunfeng, Kvikstad, Erika, O’Neill, Amanda, Nioi, Paul, Parker, Meg M., Petrovski, Slavé, Runz, Heiko, Szustakowski, Joseph D., Wang, Quanli, Wong, Emily, Cordova-Palomera, Aldo, Smith, Erin N., Szalma, Sandor, Zheng, Xiuwen, Esmaeeli, Sahar, Davis, Justin W., Lai, Yi-Pin, Chen, Xing, Justice, Anne E., Leader, Joseph B., Mirshahi, Tooraj, Carey, David J., Verma, Anurag, Sirugo, Giorgio, Ritchie, Marylyn D., Rader, Daniel J., Povysil, Gundula, Goldstein, David B., Kiryluk, Krzysztof, Pairo-Castineira, Erola, Rawlik, Konrad, Pasko, Dorota, Walker, Susan, Meynert, Alison, Kousathanas, Athanasios, Moutsianas, Loukas, Tenesa, Albert, Caulfield, Mark, Scott, Richard, Wilson, James F., Baillie, J. Kenneth, Butler-Laporte, Guillaume, Nakanishi, Tomoko, Lathrop, Mark, Richards, J. Brent, Jones, Marcus, Balasubramanian, Suganthi, Salerno, William, Shuldiner, Alan R., Marchini, Jonathan, Overton, John D., Habegger, Lukas, Cantor, Michael N., Reid, Jeffrey G., Baras, Aris, Abecasis, Goncalo R., Ferreira, Manuel A.R.

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Abstract 14556: Deep Phenotyping APOC3 Knockouts in a Population With High Consanguinity by Khalid, Shareef, Khan, Maleeha Z, Wu, Liya, Jahanzaib, Muhammad, Saeed, Subhan, Mian, M. Rehan, Liaqat, Muhammad Bilal, Rasheed, Asif, Millar, John S, Rader, Daniel J, Saleheen, Danish

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MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk by Surakka, Ida, Fritsche, Lars G., Zhou, Wei, Backman, Joshua, Kosmicki, Jack A., Lu, Haocheng, Brumpton, Ben, Nielsen, Jonas B., Gabrielsen, Maiken E., Skogholt, Anne Heidi, Wolford, Brooke, Graham, Sarah E., Chen, Y. Eugene, Lee, Seunggeun, Kang, Hyun Min, Langhammer, Arnulf, Forsmo, Siri, Åsvold, Bjørn O., Styrkarsdottir, Unnur, Holm, Hilma, Gudbjartsson, Daniel, Stefansson, Kari, Baras, Aris, Abecasis, Goncalo R., Hveem, Kristian, Willer, Cristen J.

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Polygenic Risk of Psychiatric Disorders Exhibits Cross-trait Associations in Electronic Health Record Data From European Ancestry Individuals by Kember, Rachel L., Merikangas, Alison K., Verma, Shefali S., Verma, Anurag, Judy, Renae, Abecasis, Goncalo, Baras, Aris, Cantor, Michael, Coppola, Giovanni, Economides, Aris, Lotta, Luca, Overton, John D., Reid, Jeffrey G., Shuldiner, Alan, Beechert, Christina, Forsythe, Caitlin, Fuller, Erin D., Gu, Zhenhua, Lattari, Michael, Lopez, Alexander, Schleicher, Thomas D., Padilla, Maria Sotiropoulos, Toledo, Karina, Widom, Louis, Wolf, Sarah E., Pradhan, Manasi, Manoochehri, Kia, Ulloa, Ricardo H., Bai, Xiaodong, Balasubramanian, Suganthi, Barnard, Leland, Blumenfeld, Andrew, Eom, Gisu, Habegger, Lukas, Hahn, Young, Hawes, Alicia, Khalid, Shareef, Maxwell, Evan K., Salerno, William, Staples, Jeffrey C., Yadav, Ashish, Jones, Marcus B., Mitnaul, Lyndon J., Damrauer, Scott M., Ritchie, Marylyn D., Rader, Daniel J., Bućan, Maja

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GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms by Ward, Lucas D., Tu, Ho-Chou, Quenneville, Chelsea B., Tsour, Shira, Flynn-Carroll, Alexander O., Parker, Margaret M., Deaton, Aimee M., Haslett, Patrick A. J., Lotta, Luca A., Verweij, Niek, Ferreira, Manuel A. R., Baras, Aris, Hinkle, Gregory, Nioi, Paul

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Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone by Dunn, Michael E., Kithcart, Aaron, Kim, Jee Hae, Ho, Andre Jo-Hao, Franklin, Matthew C., Romero Hernandez, Annabel, de Hoon, Jan, Botermans, Wouter, Meyer, Jonathan, Jin, Ximei, Zhang, Dongqin, Torello, Justin, Jasewicz, Daniel, Kamat, Vishal, Garnova, Elena, Liu, Nina, Rosconi, Michael, Pan, Hao, Karnik, Satyajit, Burczynski, Michael E., Zheng, Wenjun, Rafique, Ashique, Nielsen, Jonas B., De, Tanima, Verweij, Niek, Pandit, Anita, Locke, Adam, Chalasani, Naga, Melander, Olle, Schwantes-An, Tae-Hwi, Baras, Aris, Lotta, Luca A., Musser, Bret J., Mastaitis, Jason, Devalaraja-Narashimha, Kishor B., Rankin, Andrew J., Huang, Tammy, Herman, Gary, Olson, William, Murphy, Andrew J., Yancopoulos, George D., Olenchock, Benjamin A., Morton, Lori

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Gene-level analysis of rare variants in 379,066 whole exome sequences identifies an association of GIGYF1 loss of function with type 2 diabetes by Deaton, Aimee M., Parker, Margaret M., Ward, Lucas D., Flynn-Carroll, Alexander O., BonDurant, Lucas, Hinkle, Gregory, Akbari, Parsa, Lotta, Luca A., Baras, Aris, Nioi, Paul

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Tumor suppressor genes and allele-specific expression: mechanisms and significance by Clayton, Evan A, Khalid, Shareef, Ban, Dongjo, Wang, Lu, Jordan, I King, McDonald, John F

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Genetic Susceptibility to Mood Disorders and Risk of Stroke: A Polygenic Risk Score and Mendelian Randomization Study by Sun, Jiangming, Borné, Yan, Edsfeldt, Andreas, Wang, Yunpeng, Pan, Mengyu, Melander, Olle, Engström, Gunnar, Gonçalves, Isabel

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Thrombotic risk determined by rare and common SERPINA1 variants in a population‐based cohort study by Manderstedt, Eric, Halldén, Christer, Lind‐Halldén, Christina, Elf, Johan, Svensson, Peter J., Engström, Gunnar, Melander, Olle, Baras, Aris, Lotta, Luca A., Zöller, Bengt, Abecasis, Goncalo, Cantor, Michael, Coppola, Giovanni, Economides, Aris, Overton, John D., Reid, Jeffrey G., Shuldiner, Alan, Beechert, Christina, Forsythe, Caitlin, Fuller, Erin D., Gu, Zhenhua, Lattari, Michael, Lopez, Alexander, Manoochehri, Kia, Overton, John D., Padilla, Maria Sotiropoulos, Pradhan, Manasi, Schleicher, Thomas D., Ulloa, Ricardo H., Widom, Louis, Wolf, Sarah E., Bai, Xiaodong, Balasubramanian, Suganthi, Blumenfeld, Andrew, Boutkov, Boris, Eom, Gisu, Habegger, Lukas, Hawes, Alicia, Khalid, Shareef, Krasheninina, Olga, Lanche, Rouel, Mansfield, Adam J., Maxwell, Evan K., Nafde, Mrunali, O’Keeffe, Sean, Orelus, Max, Panea, Razvan, Polanco, Tommy, Rasool, Ayesha, Reid, Jeffrey G., Salerno, William, Staples, Jeffrey C., Jones, Marcus B., Mighty, Jason, Mitnaul, Lyndon J.

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Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection by Zhang, Chao, Verma, Anurag, Feng, Yuanqing, Melo, Marcelo C R, McQuillan, Michael, Hansen, Matthew, Lucas, Anastasia, Park, Joseph, Ranciaro, Alessia, Thompson, Simon, Rubel, Meagan A, Campbell, Michael C, Beggs, William, Hirbo, Jibril, Wata Mpoloka, Sununguko, George Mokone, Gaonyadiwe, Nyambo, Thomas, Wolde Meskel, Dawit, Belay, Gurja, Fokunang, Charles, Njamnshi, Alfred K, Omar, Sabah A, Williams, Scott M, Rader, Daniel J, Ritchie, Marylyn D, de la Fuente-Nunez, Cesar, Sirugo, Giorgio, Tishkoff, Sarah A

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Heterozygosity for a Pathogenic Variant in SLC12A3 That Causes Autosomal Recessive Gitelman Syndrome Is Associated with Lower Serum Potassium by Wan, Xuesi, Perry, James, Zhang, Haichen, Jin, Feng, Ryan, Kathleen A, Van Hout, Cristopher, Reid, Jeffrey, Overton, John, Baras, Aris, Han, Zhe, Streeten, Elizabeth, Li, Yanbing, Mitchell, Braxton D, Shuldiner, Alan R, Fu, Mao

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Survival and Predictors of Mortality of Congenital Diaphragmatic Hernia in Newborns at a Tertiary Care Hospital in Saudi Arabia by Al-Shareef, Khalid, Bhader, Mohammed, Alhindi, Mohammed, Helmi, Khalid, Ashour, Salman, Moustafa, Ahmed, Al-Harbi, Abdullah, Abushouk, Amir, AlQurashi, Mansour A

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Assessment of genetic susceptibility to multiple primary cancers through whole-exome sequencing in two large multi-ancestry studies by Cavazos, Taylor B, Kachuri, Linda, Graff, Rebecca E, Nierenberg, Jovia L, Thai, Khanh K, Alexeeff, Stacey, Van Den Eeden, Stephen, Corley, Douglas A, Kushi, Lawrence H, Hoffmann, Thomas J, Ziv, Elad, Habel, Laurel A, Jorgenson, Eric, Sakoda, Lori C, Witte, John S

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Classic Thrombophilias and Thrombotic Risk Among Middle-Aged and Older Adults: A Population-Based Cohort Study by Manderstedt, Eric, Lind-Halldén, Christina, Halldén, Christer, Elf, Johan, Svensson, Peter J, Dahlbäck, Björn, Engström, Gunnar, Melander, Olle, Baras, Aris, Lotta, Luca A, Zöller, Bengt

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