Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia by Richter-Pechańska, P, Kunz, J B, Hof, J, Zimmermann, M, Rausch, T, Bandapalli, O R, Orlova, E, Scapinello, G, Sagi, J C, Stanulla, M, Schrappe, M, Cario, G, Kirschner-Schwabe, R, Eckert, C, Benes, V, Korbel, J O, Muckenthaler, M U, Kulozik, A E

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High VLA-4 expression is associated with adverse outcome and distinct gene expression changes in childhood B-cell precursor acute lymphoblastic leukemia at first relapse by SHALAPOUR, Shabnam, HOF, Jana, KIRSCHNER-SCHWABE, Renate, BASTIAN, Lorenz, ECKERT, Cornelia, PRADA, Javier, HENZE, Günter, VON STACKELBERG, Arend, SEEGER, Karl

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Intragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia? by Schwab, Claire, Nebral, Karin, Chilton, Lucy, Leschi, Cristina, Waanders, Esmé, Boer, Judith M., Žaliová, Markéta, Sutton, Rosemary, Öfverholm, Ingegerd Ivanov, Ohki, Kentaro, Yamashita, Yuka, Groeneveld-Krentz, Stefanie, Froňková, Eva, Bakkus, Marleen, Tchinda, Joelle, Barbosa, Thayana da Conceição, Fazio, Grazia, Mlynarski, Wojciech, Pastorczak, Agata, Cazzaniga, Giovanni, Pombo-de-Oliveira, Maria S., Trka, Jan, Kirschner-Schwabe, Renate, Imamura, Toshihiko, Barbany, Gisela, Stanulla, Martin, Attarbaschi, Andishe, Panzer-Grümayer, Renate, Kuiper, Roland P., den Boer, Monique L., Cavé, Hélène, Moorman, Anthony V., Harrison, Christine J., Strehl, Sabine

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S130 TRANSIENT SUBCLONES CARRYING NT5C2 MUTATIONS DEFINE A HIGH‐RISK PATIENT GROUP WITH POOR OUTCOME IN PEDIATRIC RELAPSED B‐CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA by Pogodzinski, M.J., Hof, J., Groeneveld‐Krentz, S., Szymansky, A., Stackelberg, A., Ferrando, A.A., Eckert, C., Kirschner‐Schwabe, R.

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The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse by Bandapalli, Obul R, Schuessele, Stephanie, Kunz, Joachim B, Rausch, Tobias, Stütz, Adrian M, Tal, Noa, Geron, Ifat, Gershman, Nava, Izraeli, Shai, Eilers, Juliane, Vaezipour, Nina, Kirschner-Schwabe, Renate, Hof, Jana, von Stackelberg, Arend, Schrappe, Martin, Stanulla, Martin, Zimmermann, Martin, Koehler, Rolf, Avigad, Smadar, Handgretinger, Rupert, Frismantas, Viktoras, Bourquin, Jean Pierre, Bornhauser, Beat, Korbel, Jan O, Muckenthaler, Martina U, Kulozik, Andreas E

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Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation by Kunz, Joachim B, Rausch, Tobias, Bandapalli, Obul R, Eilers, Juliane, Pechanska, Paulina, Schuessele, Stephanie, Assenov, Yassen, Stütz, Adrian M, Kirschner-Schwabe, Renate, Hof, Jana, Eckert, Cornelia, von Stackelberg, Arend, Schrappe, Martin, Stanulla, Martin, Koehler, Rolf, Avigad, Smadar, Elitzur, Sarah, Handgretinger, Rupert, Benes, Vladimir, Weischenfeldt, Joachim, Korbel, Jan O, Muckenthaler, Martina U, Kulozik, Andreas E

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NOTCH1 mutation, TP53 alteration and myeloid antigen expression predict outcome heterogeneity in children with first relapse of T-cell acute lymphoblastic leukemia by Hof, Jana, Kox, Corinne, Groeneveld-Krentz, Stefanie, Bandapalli, Obul R, Karawajew, Leonid, Schedel, Katharina, Kunz, Joachim B, Eckert, Cornelia, Ludwig, Wolf-Dieter, Ratei, Richard, Rhein, Peter, Henze, Günter, Muckenthaler, Martina U, Kulozik, Andreas E, von Stackelberg, Arend, Kirschner-Schwabe, Renate

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Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia by Meissner, Barbara, Bartram, Thies, Eckert, Cornelia, Trka, Jan, Panzer-Grümayer, Renate, Hermanova, Ivana, Ellinghaus, Eva, Franke, Andre, Möricke, Anja, Schrauder, André, Teigler-Schlegel, Andrea, Dörge, Petra, von Stackelberg, Arend, Basso, Giuseppe, Bartram, Claus R, Kirschner-Schwabe, Renate, Bornhäuser, Beat, Bourquin, Jean-Pierre, Cazzaniga, Giovanni, Hauer, Julia, Attarbaschi, Andishe, Izraeli, Shai, Zaliova, Marketa, Cario, Gunnar, Zimmermann, Martin, Avigad, Smadar, Sokalska-Duhme, Magdalena, Metzler, Markus, Schrappe, Martin, Koehler, Rolf, Te Kronnie, Geertruy, Stanulla, Martin

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Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia by Tzoneva, Gannie, Dieck, Chelsea L., Oshima, Koichi, Ambesi-Impiombato, Alberto, Sánchez-Martín, Marta, Madubata, Chioma J., Khiabanian, Hossein, Yu, Jiangyan, Waanders, Esme, Iacobucci, Ilaria, Sulis, Maria Luisa, Kato, Motohiro, Koh, Katsuyoshi, Paganin, Maddalena, Basso, Giuseppe, Gastier-Foster, Julie M., Loh, Mignon L., Kirschner-Schwabe, Renate, Mullighan, Charles G., Rabadan, Raul, Ferrando, Adolfo A.

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Targeted Deep Sequencing of Genetic Alterations Identified By Whole Exome Sequencing Reveals Clonal Evolution in Pediatric T-Lymphoblastic Leukemia by Kunz, Joachim, Bandapalli, Obul R, Rausch, Tobias, Stuetz, Adrian, Pechanska, Paulina, Assenov, Yassen, Eilers, Juliane, Orlova, Elena, Sagi, Judit, Stanulla, Martin, Schrappe, Martin, Handgretinger, Rupert, Kirschner-Schwabe, Renate, Hof, Jana, Eckert, Cornelia, Avigad, Smadar, Koehler, Rolf, Muckenthaler, Martina U., Korbel, Jan, Kulozik, Andreas E

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C20orf94 deletion Is Strongly Associated with TEL/AML1 Rearrangement and Links Illegitimate V(D)J Recombination with Gender Bias In Childhood Acute Lymphoblastic Leukemia by Meissner, Barbara, Bartram, Thies, Eckert, Cornelia, Koehler, Rolf, Trka, Jan, Hermanova, Ivana, Breithaupt, Petra, Zimmermann, Martin, Cario, Gunnar, Schrauder, André, Möricke, Anja, Cazzaniga, Giovanni, Kronnie, Geertruy, Kirschner-Schwabe, Renate, von Stackelberg, Arend, Harbott, Jochen, Panzer-Gruemayer, Renate, Bourquin, Jean-Pierre, Franke, Andre, Ellinghaus, Eva, Schreiber, Stefan, Bartram, Claus R, Schrappe, Martin, Stanulla, Martin

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Very Early/Early Relapses of ALL Show Unexpected Changes of Clonal Markers and High Heterogeneity in Initial and Relapse Treatment Response: ALL-BFM 2000 and ALL-REZ BFM 96/2002 by Eckert, Cornelia, Koehler, Rolf, Flohr, Thomas, Hagedorn, Nikola, Moericke, Anja, Stanulla, Martin, Kirschner-Schwabe, Renate, Cario, Gunnar, von Stackelberg, Arend, Bartram, Claus R, Henze, Guenter, Schrappe, Martin, Schrauder, Andre

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