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Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: Synthesis, biological evaluation and molecular modelling
by
Marshall, Andrew J.
,
Lill, Claire L.
,
Chao, Mindy
,
Kolekar, Sharada V.
,
Lee, Woo-Jeong
,
Marshall, Elaine S.
,
Baguley, Bruce C.
,
Shepherd, Peter R.
,
Denny, William A.
,
Flanagan, Jack U.
,
Rewcastle, Gordon W.
Published in
Bioorganic & medicinal chemistry
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Bioorganic & Medicinal Chemistry
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Antineoplastic Agents - Chemical Synthesis
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Antineoplastic Agents - Pharmacology
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Biochemistry & Molecular Biology
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Cell Line, Tumor
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Cell Survival - Drug Effects
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Chemistry
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Chemistry, Medicinal
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Chemistry, Organic
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Class Ia Phosphatidylinositol 3-Kinase - Antagonists & Inhibitors
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Class Ia Phosphatidylinositol 3-Kinase - Chemistry
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Class Ia Phosphatidylinositol 3-Kinase - Metabolism
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Comparative Modelling
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Docking
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Humans
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Life Sciences & Biomedicine
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Molecular Docking Simulation
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Molecular Dynamics Simulation
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Morpholines - Chemical Synthesis
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Morpholines - Pharmacology
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P110Î’
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Sciencedirect (Elsevier)
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Sciencedirect Freedom Collection 2022-2024
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Backfile Package - Organic Chemistry (Legacy) [Yco]
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