New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan by Khomenko, Tatyana M, Zakharenko, Alexandra L, Kornienko, Tatyana E, Chepanova, Arina A, Dyrkheeva, Nadezhda S, Artemova, Anastasia O, Korchagina, Dina V, Achara, Chigozie, Curtis, Anthony, Reynisson, Jóhannes, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

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New Dual Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 and 2 Based on Deoxycholic Acid: Design, Synthesis, Cytotoxicity, and Molecular Modeling by Salomatina, Oksana V, Kornienko, Tatyana E, Zakharenko, Alexandra L, Komarova, Nina I, Achara, Chigozie, Reynisson, Jóhannes, Salakhutdinov, Nariman F, Lavrik, Olga I, Volcho, Konstantin P

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Enhancement of the Antitumor and Antimetastatic Effect of Topotecan and Normalization of Blood Counts in Mice with Lewis Carcinoma by Tdp1 Inhibitors-New Usnic Acid Derivatives by Kornienko, Tatyana E, Chepanova, Arina A, Zakharenko, Alexandra L, Filimonov, Aleksandr S, Luzina, Olga A, Dyrkheeva, Nadezhda S, Nikolin, Valeriy P, Popova, Nelly A, Salakhutdinov, Nariman F, Lavrik, Olga I

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The Lipophilic Purine Nucleoside-Tdp1 Inhibitor-Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo by Chernyshova, Irina A, Zakharenko, Aleksandra L, Kurochkin, Nikolay N, Dyrkheeva, Nadezhda S, Kornienko, Tatyana E, Popova, Nelly A, Nikolin, Valeriy P, Ilina, Ekaterina S, Zharkov, Timofey D, Kupryushkin, Maxim S, Oslovsky, Vladimir E, Drenichev, Mikhail S, Lavrik, Olga I

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Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan by Munkuev, Aldar A, Dyrkheeva, Nadezhda S, Kornienko, Tatyana E, Ilina, Ekaterina S, Ivankin, Dmitry I, Suslov, Evgeniy V, Korchagina, Dina V, Gatilov, Yuriy V, Zakharenko, Alexandra L, Malakhova, Anastasia A, Reynisson, Jóhannes, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

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Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties by Ivankin, Dmitry I, Kornienko, Tatyana E, Mikhailova, Marina A, Dyrkheeva, Nadezhda S, Zakharenko, Alexandra L, Achara, Chigozie, Reynisson, Jóhannes, Golyshev, Victor M, Luzina, Olga A, Volcho, Konstantin P, Salakhutdinov, Nariman F, Lavrik, Olga I

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New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1 by Dyrkheeva, Nadezhda S, Filimonov, Aleksandr S, Luzina, Olga A, Orlova, Kristina A, Chernyshova, Irina A, Kornienko, Tatyana E, Malakhova, Anastasia A, Medvedev, Sergey P, Zakharenko, Alexandra L, Ilina, Ekaterina S, Anarbaev, Rashid O, Naumenko, Konstantin N, Klabenkova, Kristina V, Burakova, Ekaterina A, Stetsenko, Dmitry A, Zakian, Suren M, Salakhutdinov, Nariman F, Lavrik, Olga I

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Pharmacokinetic study of Tdp1 inhibitor resulted in a significant increase in antitumor effect in the treatment of Lewis lung carcinoma in mice by its combination with topotecan by Okhina, Alina A., Kornienko, Tatyana E., Rogachev, Artem D., Luzina, Olga A., Popova, Nelly A., Nikolin, Valery P., Zakharenko, Alexandra L., Dyrkheeva, Nadezhda S., Pokrovsky, Andrey G., Salakhutdinov, Nariman F., Lavrik, Olga I.

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Synthesis of adamantane-monoterpene conjugates with 1,3,4-thiadiazol-2(3H)-imine linker and evaluation of their inhibitory activity against TDP1 by Munkuev, Aldar A., Zakharenko, Alexandra L., Kornienko, Tatyana E., Dyrkheeva, Nadezhda S., Ilina, Ekaterina S., Suslov, Evgeniy V., Issa, Fatima, Achara, Chigozie, Reynisson, Jóhannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.

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