Expression and Induction of Cytochromes P450 in Rat White Adipose Tissue by Yoshinari, Kouichi, Sato, Takeshi, Okino, Nao, Sugatani, Junko, Miwa, Masao

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Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury by Kaito, Shunnosuke, Takeshita, Jun-Ichi, Iwata, Misaki, Sasaki, Takamitsu, Hosaka, Takuomi, Shizu, Ryota, Yoshinari, Kouichi

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Development of a strategy to identify and evaluate direct and indirect activators of constitutive androstane receptor in rats by Sato, Takumi, Shizu, Ryota, Miura, Yoshie, Hosaka, Takuomi, Kanno, Yuichiro, Sasaki, Takamitsu, Yoshinari, Kouichi

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Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: Comparative study with in vitro transactivation assays by Murase, Wataru, Kubota, Atsuhito, Ikeda-Araki, Atsuko, Terasaki, Masaru, Nakagawa, Koji, Shizu, Ryota, Yoshinari, Kouichi, Kojima, Hiroyuki

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Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation by Shizu, Ryota, Makida, Natsuki, Sobe, Keiichiro, Ishimura, Mai, Takeshita, Aki, Hosaka, Takuomi, Kanno, Yuichiro, Sasaki, Takamitsu, Yoshinari, Kouichi

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Identification of average molecular weight by Shimizu, Yuki, Sasaki, Takamitsu, Takeshita, Jun-ichi, Watanabe, Michiko, Shizu, Ryota, Hosaka, Takuomi, Yoshinari, Kouichi

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SREBP-2 negatively regulates FXR-dependent transcription of FGF19 in human intestinal cells by Miyata, Masaaki, Hata, Tatsuya, Yamazoe, Yasushi, Yoshinari, Kouichi

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Pregnenolone 16α-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation by Kodama, Susumu, Shimura, Takuto, Kuribayashi, Hideaki, Abe, Taiki, Yoshinari, Kouichi

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A Novel In Vitro Membrane Permeability Methodology Using Three-dimensional Caco-2 Tubules in a Microphysiological System Which Better Mimics In Vivo Physiological Conditions by Hagiwara, Yuki, Kumagai, Harumi, Ouwerkerk, Niels, Gijzen, Linda, Annida, Rumaisha, Bokkers, Marleen, van Vught, Remko, Yoshinari, Kouichi, Katakawa, Yoshifumi, Motonaga, Kei, Tajiri, Tomokazu

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Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator by Watanabe, Keisuke, Sakurai, Kaori, Tsuchiya, Yuri, Yamazoe, Yasushi, Yoshinari, Kouichi

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Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective Na V 1.7 Inhibitor DS-1971a, a Mixed... by Asano, Daigo, Nakamura, Koichi, Nishiya, Yumi, Shiozawa, Hideyuki, Takakusa, Hideo, Shibayama, Takahiro, Inoue, Shin-Ichi, Shinozuka, Tsuyoshi, Hamada, Takakazu, Yahara, Chizuko, Watanabe, Nobuaki, Yoshinari, Kouichi

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Chemical characterization of anemia-inducing aniline-related substances and their application to the construction of a decision tree-based anemia prediction model by Asai, Takaho, Takeshita, Jun-ichi, Shimizu, Yuki, Tochikubo, Yoshihiro, Shizu, Ryota, Hosaka, Takuomi, Kanno, Yuichiro, Yoshinari, Kouichi

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Comparative study of the effect of 17 parabens on PXR-, CAR- and PPARα-mediated transcriptional activation by Fujino, Chieri, Watanabe, Yoko, Sanoh, Seigo, Hattori, Shoko, Nakajima, Hiroyuki, Uramaru, Naoto, Kojima, Hiroyuki, Yoshinari, Kouichi, Ohta, Shigeru, Kitamura, Shigeyuki

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In vivo-in vitro correlation of antitumor activity of heat shock protein 90 (HSP90) inhibitors with a pharmacokinetics/pharmacodynamics analysis using NCI-N87 xenograft mice by Ohminato, Noriaki, Nagayasu, Miho, Ozeki, Kazuhisa, Saitoh, Ryoichi, Ono, Naomi, Shibahara, Norihito, Suda, Atsushi, Yoshinari, Kouichi

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Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase by Asano, Daigo, Shibayama, Takahiro, Shiozawa, Hideyuki, Inoue, Shin-ichi, Shinozuka, Tsuyoshi, Murata, Shinji, Watanabe, Nobuaki, Yoshinari, Kouichi

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Chimeric Mice With Humanized Livers Demonstrate Human-Specific Hepatotoxicity Caused by a Therapeutic Antibody Against TRAIL-Receptor 2/Death Receptor 5 by Nihira, Kaito, Nan-ya, Ken-ichiro, Kakuni, Masakazu, Ono, Yoko, Yoshikawa, Yukitaka, Ota, Toshio, Hiura, Masanori, Yoshinari, Kouichi

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Antiepileptic Drug–Activated Constitutive Androstane Receptor Inhibits Peroxisome Proliferator–Activated Receptor α and Peroxisome Proliferator–Activated Receptor γ Coactivator 1α–... by Shizu, Ryota, Otsuka, Yuta, Ezaki, Kanako, Ishii, Chizuru, Arakawa, Shingo, Amaike, Yuto, Abe, Taiki, Hosaka, Takuomi, Sasaki, Takamitsu, Kanno, Yuichiro, Miyata, Masaaki, Yamazoe, Yasushi, Yoshinari, Kouichi

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Evaluation of species differences in the metabolism of the selective Na V 1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase by Asano, Daigo, Shibayama, Takahiro, Shiozawa, Hideyuki, Inoue, Shin-ichi, Shinozuka, Tsuyoshi, Murata, Shinji, Watanabe, Nobuaki, Yoshinari, Kouichi

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CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate by Asano, Daigo, Hamaue, Syoya, Zahir, Hamim, Shiozawa, Hideyuki, Nishiya, Yumi, Kimura, Takako, Kazui, Miho, Yamamura, Naotoshi, Ikeguchi, Marie, Shibayama, Takahiro, Inoue, Shin-Ichi, Shinozuka, Tsuyoshi, Watanabe, Toshiyuki, Yahara, Chizuko, Watanabe, Nobuaki, Yoshinari, Kouichi

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CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective Na V 1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate by Asano, Daigo, Hamaue, Syoya, Zahir, Hamim, Shiozawa, Hideyuki, Nishiya, Yumi, Kimura, Takako, Kazui, Miho, Yamamura, Naotoshi, Ikeguchi, Marie, Shibayama, Takahiro, Inoue, Shin-Ichi, Shinozuka, Tsuyoshi, Watanabe, Toshiyuki, Yahara, Chizuko, Watanabe, Nobuaki, Yoshinari, Kouichi

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