Artificial intelligence in digital pathology: a roadmap to routine use in clinical practice by Colling, Richard, Pitman, Helen, Oien, Karin, Rajpoot, Nasir, Macklin, Philip, Bachtiar, Velicia, Booth, Richard, Bryant, Alyson, Bull, Joshua, Bury, Jonathan, Carragher, Fiona, Colling, Richard, Collins, Graeme, Craig, Clare, da Silva, Maria Freitas, Gosling, Daniel, Jacobs, Jaco, Kajland‐Wilén, Lena, Karling, Johanna, Lawler, Darragh, Lee, Stephen, Macklin, Philip, Miller, Keith, Mozolowski, Guy, Nicholson, Richard, O'Connor, Daniel, Rahbek, Mikkel, Rajpoot, Nasir, Sumner, Alan, Vossen, Dirk, White, Kieron, Wing, Charlotte, Wright, Corrina, Snead, David, Sackville, Tony, Verrill, Clare

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The development and validation of the Virtual Tissue Matrix, a software application that facilitates the review of tissue microarrays on line by Conway, Catherine M, O'Shea, Deirdre, O'Brien, Sallyann, Lawler, Darragh K, Dodrill, Graham D, O'Grady, Anthony, Barrett, Helen, Gulmann, Christian, O'Driscoll, Lorraine, Gallagher, William M, Kay, Elaine W, O'Shea, Daniel G

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Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification by Dunne, Philip D., Alderdice, Matthew, O'Reilly, Paul G., Roddy, Aideen C., McCorry, Amy M. B., Richman, Susan, Maughan, Tim, McDade, Simon S., Johnston, Patrick G., Longley, Daniel B., Kay, Elaine, McArt, Darragh G., Lawler, Mark

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Immune status is prognostic for poor survival in colorectal cancer patients and is associated with tumour hypoxia by Craig, Stephanie G., Humphries, Matthew P., Alderdice, Matthew, Bingham, Victoria, Richman, Susan D., Loughrey, Maurice B., Coleman, Helen G., Viratham-Pulsawatdi, Amelie, McCombe, Kris, Murray, Graeme I., Blake, Andrew, Domingo, Enric, Robineau, James, Brown, Louise, Fisher, David, Seymour, Matthew T., Quirke, Phil, Bankhead, Peter, McQuaid, Stephen, Lawler, Mark, McArt, Darragh G., Maughan, Tim S., James, Jacqueline A., Salto-Tellez, Manuel

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Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer by Dunne, Philip D, McArt, Darragh G, Bradley, Conor A, O'Reilly, Paul G, Barrett, Helen L, Cummins, Robert, O'Grady, Tony, Arthur, Ken, Loughrey, Maurice B, Allen, Wendy L, McDade, Simon S, Waugh, David J, Hamilton, Peter W, Longley, Daniel B, Kay, Elaine W, Johnston, Patrick G, Lawler, Mark, Salto-Tellez, Manuel, Van Schaeybroeck, Sandra

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Prospective patient stratification into robust cancer‐cell intrinsic subtypes from colorectal cancer biopsies by Alderdice, Matthew, Richman, Susan D, Gollins, Simon, Stewart, James P, Hurt, Chris, Adams, Richard, McCorry, Amy MB, Roddy, Aideen C, Vimalachandran, Dale, Isella, Claudio, Medico, Enzo, Maughan, Tim, McArt, Darragh G, Lawler, Mark, Dunne, Philip D

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ACE: A Workbench Using Evolutionary Genetic Algorithms for Analyzing Association in TCGA by Gilmore, Alan R, Alderdice, Matthew, Savage, Kienan I, O'Reilly, Paul G, Roddy, Aideen C, Dunne, Philip D, Lawler, Mark, McDade, Simon S, Waugh, David J, McArt, Darragh G

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Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival by Alderdice, Matthew, Dunne, Philip D, Cole, Aidan J, O’Reilly, Paul G, McArt, Darragh G, Bingham, Vicky, Fuchs, Marc-Aurel, McQuaid, Stephen, Loughrey, Maurice B, Murray, Graeme I, Samuel, Leslie M, Lawler, Mark, Wilson, Richard H, Salto-Tellez, Manuel, Coyle, Vicky M

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Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer by Bradley, Conor A, Dunne, Philip D, Bingham, Victoria, McQuaid, Stephen, Khawaja, Hajrah, Craig, Stephanie, James, Jackie, Moore, Wendy L, McArt, Darragh G, Lawler, Mark, Dasgupta, Sonali, Johnston, Patrick G, Van Schaeybroeck, Sandra

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Evolutionary genetic algorithm identifies IL2RB as a potential predictive biomarker for immune-checkpoint therapy in colorectal cancer by Alderdice, Matthew, Craig, Stephanie G, Humphries, Matthew P, Gilmore, Alan, Johnston, Nicole, Bingham, Victoria, Coyle, Vicky, Senevirathne, Seedevi, Longley, Daniel B, Loughrey, Maurice B, McQuaid, Stephen, James, Jacqueline A, Salto-Tellez, Manuel, Lawler, Mark, McArt, Darragh G

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Advances in molecular quantum chemistry contained in the Q-Chem 4 program package by Shao, Yihan, Gan, Zhengting, Epifanovsky, Evgeny, Gilbert, Andrew T.B., Kussmann, Joerg, Lange, Adrian W., Ghosh, Debashree, Goldey, Matthew, Kaliman, Ilya, Khaliullin, Rustam Z., Kuś, Tomasz, Richard, Ryan M., Rohrdanz, Mary A., Steele, Ryan P., Sundstrom, Eric J., Zuev, Dmitry, Albrecht, Ben, Alguire, Ethan, Beran, Gregory J. O., Berquist, Eric, Brandhorst, Kai, Brown, Shawn T., Casanova, David, Chang, Chun-Min, Chen, Yunqing, Chien, Siu Hung, Closser, Kristina D., Crittenden, Deborah L., Diedenhofen, Michael, DiStasio, Robert A., Dutoi, Anthony D., Fatehi, Shervin, Fusti-Molnar, Laszlo, Ghysels, An, Golubeva-Zadorozhnaya, Anna, Gomes, Joseph, Hanson-Heine, Magnus W.D., Harbach, Philipp H.P., Hauser, Andreas W., Holden, Zachary C., Jagau, Thomas-C., Ji, Hyunjun, Kaduk, Benjamin, Khistyaev, Kirill, King, Rollin A., Klunzinger, Phil, Kowalczyk, Tim, Krauter, Caroline M., Laurent, Adèle D., Levchenko, Sergey V., Lin, Ching Yeh, Liu, Fenglai, Lochan, Rohini C., Mao, Shan-Ping, Marenich, Aleksandr V., Oana, C. Melania, Olivares-Amaya, Roberto, O'Neill, Darragh P., Parkhill, John A., Perrine, Trilisa M., Peverati, Roberto, Prociuk, Alexander, Russ, Nicholas J., Sharada, Shaama M., Sharma, Sandeep, Sodt, Alexander, Stein, Tamar, Stück, David, Su, Yu-Chuan, Thom, Alex J.W., Tsuchimochi, Takashi, Vanovschi, Vitalii, Vogt, Leslie, Vydrov, Oleg, Wenzel, Jan, White, Alec, Williams, Christopher F., Yang, Jun, Yeganeh, Sina, Zhang, Igor Ying, Zhang, Xing, Zhao, Yan, Chan, Garnet K.L., Cramer, Christopher J., Gordon, Mark S., Hehre, Warren J., Klamt, Andreas, Schaefer, Henry F., Truhlar, Donald G., Xu, Xin, Dunietz, Barry D., Gwaltney, Steven R., Kong, Jing, Liang, WanZhen, Ochsenfeld, Christian, Rassolov, Vitaly A., Van Voorhis, Troy, Herbert, John M., Krylov, Anna I., Gill, Peter M.W.

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Abstract 2787: Artificial intelligence approach identifies IL2RB as a common prognostic and potential predictive biomarker associated with immune checkpoints in colorectal cancer by Alderdice, Matthew, Craig, Stephanie, Humphries, Matt, Gilmore, Alan, Bingham, Victoria, Johnston, Nicole, McQuaid, Stephen, Salto-Tellez, Manuel, Lawler, Mark, McArt, Darragh G.

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Abstract 4385: p53 activation induces a targetable dependence on FLIPL by McIntyre, Alexander, Lees, Andrea, Falcone, Fiammetta, Gregg, Gemma, Tamas, Sessler, Quinn, Gerard, Crawford, Nyree, McArt, Darragh, Dunne, Phillip, Lawler, Mark, Daniel, Longley B., McDade, Simon S.

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Immune-Derived PD-L1 Gene Expression Defines a Subgroup of Stage II/III Colorectal Cancer Patients with Favorable Prognosis Who May Be Harmed by Adjuvant Chemotherapy by Dunne, Philip D, McArt, Darragh G, O'Reilly, Paul G, Coleman, Helen G, Allen, Wendy L, Loughrey, Maurice, Van Schaeybroeck, Sandra, McDade, Simon, Salto-Tellez, Manuel, Longley, Daniel B, Lawler, Mark, Johnston, Patrick G

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Abstract LB-042: Cancer cell intrinsic gene expression signatures minimize the confounding effects of intratumoral heterogeneity in colorectal cancer patient classification by Dunne, Philip D., O'Reilly, Paul, Roddy, Aideen, Alderdice, Matthew, Richman, Susan, Maughan, Tim, McDade, Simon, Johnston, Patrick, Longley, Daniel, Kay, Elaine, McArt, Darragh, Lawler, Mark

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Stratified analysis reveals chemokine-like factor (CKLF) as a potential prognostic marker in the MSI-immune consensus molecular subtype CMS1 of colorectal cancer by Dunne, Philip D, O'Reilly, Paul G, Coleman, Helen G, Gray, Ronan T, Longley, Daniel B, Johnston, Patrick G, Salto-Tellez, Manuel, Lawler, Mark, McArt, Darragh G

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Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF -mutant stage II and III colon cancer by Dunne, Philip D, Coleman, Helen G, Bankhead, Peter, Alderdice, Matthew, Gray, Ronan T, McQuaid, Stephen, Bingham, Victoria, Loughrey, Maurice B, James, Jacqueline A, McCorry, Amy M B, Gilmore, Alan, Holohan, Caitriona, Klingbiel, Dirk, Tejpar, Sabine, Johnston, Patrick G, McArt, Darragh G, Di Nicolantonio, Federica, Longley, Daniel B, Lawler, Mark

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Delivering a research‐enabled multistakeholder partnership for enhanced patient care at a population level: The Northern Ireland Comprehensive Cancer Program by Lawler, Mark, Gavin, Anna, Salto‐Tellez, Manuel, Kennedy, Richard D., Van Schaeybroeck, Sandra, Wilson, Richard H., Harkin, Denis Paul, Grayson, Margaret, Boyd, Ruth E., Hamilton, Peter W., McArt, Darragh G., James, Jacqueline, Robson, Tracy, Ladner, Robert D., Prise, Kevin M., O'Sullivan, Joe M., Harrison, Timothy, Murray, Liam, Johnston, Patrick G., Waugh, David J.

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Assessing the stability of clinically relevant prognostic, predictive and subtyping gene expression signatures based on intra-tumoural heterogeneity in colorectal cancer by Dunne, Philip, O'Reilly, Paul, Richman, Susan, Kay, Elaine, Salto-Tellez, Manuel, Johnston, Patrick, McArt, Darragh, Lawler, Mark

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Patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies may inform prospective clinical trials by Alderdice, Matt, McCorry, Amy, Isella, Claudio, McArt, Darragh, Richman, Susan, Morton, Dion, Quirke, Philip, McDermott, Ultan, Tomlinson, Ian, Murray, Graeme, Salto-Tellez, Manuel, Gollins, Simon, Wilson, Richard, Adams, Richard, Maughan, Tim, Medico, Enzo, Bertotti, Andrea, Lawler, Mark, Dunne, Philip

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