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Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl Protease
by
Wolfe, Michael S
,
Xia, Weiming
,
Moore, Chad L
,
Leatherwood, Dartha D
,
Ostaszewski, Beth
,
Rahmati, Talat
,
Donkor, Isaac O
,
Selkoe, Dennis J
Published in
Biochemistry (Easton)
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Difluoro Ketone Peptidomimetics Suggest a Large S1 Pocket for Alzheimer's γ-Secretase: Implications for Inhibitor Design
by
Moore, Chad L
,
Leatherwood, Dartha D
,
Diehl, Thekla S
,
Selkoe, Dennis J
,
Wolfe, Michael S
Published in
Journal of medicinal chemistry
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Biochemistry
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Journal Of Medicinal Chemistry
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Alzheimer Disease - Enzymology
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Amyloid Precursor Protein Secretases
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Endopeptidases - Metabolism
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Ketones - Chemical Synthesis
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Life Sciences & Biomedicine
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Molecular Mimicry
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Protease Inhibitors - Pharmacology
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Science & Technology
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Amino Acid Sequence
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Amyloid Beta-Peptides - Antagonists & Inhibitors
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Amyloid Beta-Peptides - Biosynthesis
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Amyloid Beta-Protein Precursor - Metabolism
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Animals
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Aspartic Acid Endopeptidases - Antagonists & Inhibitors
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Aspartic Acid Endopeptidases - Chemistry
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Aspartic Acid Endopeptidases - Metabolism
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Aspartyl Proteinase
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Biochemistry & Molecular Biology
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Biological And Medical Sciences
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American Chemical Society
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American Chemical Society:jisc Collections:american Chemical Society Read & Publish Agreement 2022-2024 (Reading List)
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