Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor by Waaler, Jo, Leenders, Ruben G. G, Sowa, Sven T, Alam Brinch, Shoshy, Lycke, Max, Nieczypor, Piotr, Aertssen, Sjoerd, Murthy, Sudarshan, Galera-Prat, Albert, Damen, Eddy, Wegert, Anita, Nazaré, Marc, Lehtiö, Lari, Krauss, Stefan

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Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II by Leenders, Ruben G. G, Brinch, Shoshy Alam, Sowa, Sven T, Amundsen-Isaksen, Enya, Galera-Prat, Albert, Murthy, Sudarshan, Aertssen, Sjoerd, Smits, Johannes N, Nieczypor, Piotr, Damen, Eddy, Wegert, Anita, Nazaré, Marc, Lehtiö, Lari, Waaler, Jo, Krauss, Stefan

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Structure–Activity Relationship Studies on (R)‐PFI‐2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7 by Lenstra, Danny C., Damen, Eddy, Leenders, Ruben G. G., Blaauw, Richard H., Rutjes, Floris P. J. T., Wegert, Anita, Mecinović, Jasmin

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The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models by Brinch, Shoshy A, Amundsen-Isaksen, Enya, Espada, Sandra, Hammarström, Clara, Aizenshtadt, Aleksandra, Olsen, Petter A, Holmen, Lone, Høyem, Merete, Scholz, Hanne, Grødeland, Gunnveig, Sowa, Sven T, Galera-Prat, Albert, Lehtiö, Lari, Meerts, Ilonka A T M, Leenders, Ruben G G, Wegert, Anita, Krauss, Stefan, Waaler, Jo

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Abstract 2651: The tankyrase inhibitor OM-153 demonstrates anti-tumor effect with a therapeutic index above 10 by Brinch, Shoshy Alam, Amundsen-Isaksen, Enya, Espada, Sandra, Aizenshtadt, Aleksandra, Holmen, Lone, Hammarström, Clara, Høyem, Merete, Scholz, Hanne, Grødeland, Gunnveig, Sowa, Sven T., Galera-Prat, Albert, Lehtiö, Lari, Meerts, Ilonka A.T.M., Leenders, Ruben G. G., Wegert, Anita, Krauss, Stefan, Waaler, Jo

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Cystic renal‐epithelial derived induced pluripotent stem cells from polycystic kidney disease patients by Kenter, Annegien T., Rentmeester, Eveline, Riet, Job, Boers, Ruben, Boers, Joachim, Ghazvini, Mehrnaz, Xavier, Vanessa J., Leenders, Geert J.L.H., Verhagen, Paul C.M.S., Til, Marjan E., Eussen, Bert, Losekoot, Monique, Klein, Annelies, Peters, Dorien J.M., IJcken, Wilfred F.J., Werken, Harmen J.G., Zietse, Robert, Hoorn, Ewout J., Jansen, Gert, Gribnau, Joost H.

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Trio-based whole exome sequencing in patients with suspected sporadic inborn errors of immunity: A retrospective cohort study by Hebert, Anne, Simons, Annet, Schuurs-Hoeijmakers, Janneke H M, Koenen, Hans J P M, Zonneveld-Huijssoon, Evelien, Henriet, Stefanie S V, Schatorjé, Ellen J H, Hoppenreijs, Esther P A H, Leenders, Erika K S M, Janssen, Etienne J M, Santen, Gijs W E, de Munnik, Sonja A, van Reijmersdal, Simon V, van Rijssen, Esther, Kersten, Simone, Netea, Mihai G, Smeets, Ruben L, van de Veerdonk, Frank L, Hoischen, Alexander, van der Made, Caspar I

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Characterization of novel anthracycline prodrugs activated by human β-glucuronidase for use in antibody-directed enzyme prodrug therapy by Houba, Pieter H.J, Leenders, Ruben G.G, Boven, Epie, Scheeren, Johannes W, Pinedo, Herbert M, Haisma, Hidde J

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Novel anthracycline-spacer-β-glucuronide, -β-glucoside, and -β-galactoside prodrugs for application in selective chemotherapy by LEENDERS, R. G. G, DAMEN, E. W. P, BIJSTERVELD, E. J. A, SCHEEREN, H. W, HOUBA, P. H. J, VAN DER MEULEN-MUILEMAN, I. H, BOVEN, E, HAISMA, H. J

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Distribution and pharmacokinetics of the prodrug daunorubicin-GA3 in nude mice bearing human ovarian cancer xenografts by Houba, Pieter H.J, Boven, Epie, van der Meulen-Muileman, Ida H, Leenders, Ruben G.G, Scheeren, Johannes W, Pinedo, Herbert M, Haisma, Hidde J

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Synthesis and biological activity of β-glucuronyl carbamate-based prodrugs of paclitaxel as potential candidates for ADEPT by de Bont, Dries B.A., Leenders, Ruben G.G., Haisma, Hidde J., van der Meulen-Muileman, Ida, Scheeren, Hans W.

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