Search Results - Lightle, Sandra

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  1. 1
    Comparative functional characterization of canine IgG subclasses

    Comparative functional characterization of canine IgG subclasses by Bergeron, Lisa M., McCandless, Erin E., Dunham, Steve, Dunkle, Bill, Zhu, Yaqi, Shelly, John, Lightle, Sandra, Gonzales, Andrea, Bainbridge, Graeme

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  2. 2
    Structural evidence for substrate‐induced synergism and half‐sites reactivity in biotin carboxylase

    Structural evidence for substrate‐induced synergism and half‐sites reactivity in biotin carboxylase by Mochalkin, Igor, Miller, J. Richard, Evdokimov, Artem, Lightle, Sandra, Yan, Chunhong, Stover, Charles Ken, Waldrop, Grover L.

    Published in Protein science
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  3. 3
    The Structure of the Carboxyltransferase Component of Acetyl-CoA Carboxylase Reveals a Zinc-Binding Motif Unique to the Bacterial Enzyme

    The Structure of the Carboxyltransferase Component of Acetyl-CoA Carboxylase Reveals a Zinc-Binding Motif Unique to the Bacterial Enzyme by Bilder, Patrick, Lightle, Sandra, Bainbridge, Graeme, Ohren, Jeffrey, Finzel, Barry, Sun, Fang, Holley, Susan, Al-Kassim, Loola, Spessard, Cindy, Melnick, Michael, Newcomer, Marcia, Waldrop, Grover L

    Published in Biochemistry (Easton)
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  4. 4
    Characterization of substrate binding and catalysis in the potential antibacterial target N‐acetylglucosamine‐1‐phosphate uridyltransferase (GlmU)

    Characterization of substrate binding and catalysis in the potential antibacterial target N‐acetylglucosamine‐1‐phosphate uridyltransferase (GlmU) by Mochalkin, Igor, Lightle, Sandra, Zhu, Yaqi, Ohren, Jeffrey F., Spessard, Cindy, Chirgadze, Nickolay Y., Banotai, Craig, Melnick, Michael, McDowell, Laura

    Published in Protein science
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  5. 5
    Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain

    Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain by Hall, Troii, Emmons, Thomas L., Chrencik, Jill E., Gormley, Jennifer A., Weinberg, Robin A., Leone, Joseph W., Hirsch, Jeffrey L., Saabye, Matthew J., Schindler, John F., Day, Jacqueline E., Williams, Jennifer M., Kiefer, James R., Lightle, Sandra A., Harris, Melissa S., Guru, Siradanahalli, Fischer, H. David, Tomasselli, Alfredo G.

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  6. 6
    Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB‐78485 inhibitor

    Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB‐78485 inhibitor by Mochalkin, Igor, Knafels, John D., Lightle, Sandra

    Published in Protein science
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  7. 7
    Mutations within a human IgG2 antibody form distinct and homogeneous disulfide isomers but do not affect Fc gamma receptor or C1q binding

    Mutations within a human IgG2 antibody form distinct and homogeneous disulfide isomers but do not affect Fc gamma receptor or C1q binding by Lightle, Sandra, Aykent, Serdar, Lacher, Nathan, Mitaksov, Vesselin, Wells, Kristine, Zobel, James, Oliphant, Theodore

    Published in Protein science
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  8. 8
    Structure of a small‐molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding site

    Structure of a small‐molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding site by Mochalkin, Igor, Lightle, Sandra, Narasimhan, Lakshmi, Bornemeier, Dirk, Melnick, Michael, VanderRoest, Steven, McDowell, Laura

    Published in Protein science
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  9. 9
    Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches

    Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches by Mochalkin, Igor, Miller, J. Richard, Narasimhan, Lakshmi, Thanabal, Venkataraman, Erdman, Paul, Cox, Philip B, Prasad, J. V. N. Vara, Lightle, Sandra, Huband, Michael D, Stover, C. Kendall

    Published in ACS chemical biology
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  10. 10
    Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC

    Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC by Warmus, Joseph S., Quinn, Cheryl L., Taylor, Clarke, Murphy, Sean T., Johnson, Timothy A., Limberakis, Chris, Ortwine, Daniel, Bronstein, Joel, Pagano, Paul, Knafels, John D., Lightle, Sandra, Mochalkin, Igor, Brideau, Roger, Podoll, Terry

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  11. 11
    Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, Part I: Transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors

    Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, Part I: Transformation of selective pyrazolodiazepinone p... by Plummer, Mark S., Cornicelli, Joseph, Roark, Howard, Skalitzky, Donald J., Stankovic, Charles J., Bove, Susan, Pandit, Jayvardhan, Goodman, Annise, Hicks, James, Shahripour, Aurash, Beidler, David, Lu, Xiao Kang, Sanchez, Brian, Whitehead, Christopher, Sarver, Ron, Braden, Timothy, Gowan, Richard, Shen, Xi Qiang, Welch, Katherine, Ogden, Adam, Sadagopan, Nalini, Baum, Heidi, Miller, Howard, Banotai, Craig, Spessard, Cindy, Lightle, Sandra

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  12. 12
    Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: Optimization studies and demonstration of in vivo efficacy

    Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: Optimization studies and demonstration of in vivo... by Plummer, Mark S., Cornicelli, Joseph, Roark, Howard, Skalitzky, Donald J., Stankovic, Charles J., Bove, Susan, Pandit, Jayvardhan, Goodman, Annise, Hicks, James, Shahripour, Aurash, Beidler, David, Lu, Xiao Kang, Sanchez, Brian, Whitehead, Christopher, Sarver, Ron, Braden, Timothy, Gowan, Richard, Shen, Xi Qiang, Welch, Katherine, Ogden, Adam, Sadagopan, Nalini, Baum, Heidi, Miller, Howard, Banotai, Craig, Spessard, Cindy, Lightle, Sandra

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