Amino Acid Substitution at Phe80 of Mammalian Phenylalanine Hydroxylase Destabilizes Both Resting‐State and Activated Conformations Increasing the Population of Intermediates by Arturo, Emilia C., Merkel, George W., Borne, Elias, Hansen, Michael Riis, Lisowski, Sophia, Gupta, Kushol, Jaffe, Eileen K.

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Manipulation of a cation-π sandwich reveals conformational flexibility in phenylalanine hydroxylase by Arturo, Emilia C., Merkel, George W., Hansen, Michael R., Lisowski, Sophia, Almeida, Deeanne, Gupta, Kushol, Jaffe, Eileen K.

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Harnessing whole human liver ex situ normothermic perfusion for preclinical AAV vector evaluation by Cabanes-Creus, Marti, Liao, Sophia H. Y., Gale Navarro, Renina, Knight, Maddison, Nazareth, Deborah, Lau, Ngee-Soon, Ly, Mark, Zhu, Erhua, Roca-Pinilla, Ramon, Bugallo Delgado, Ricardo, Vicente, Ana F., Baltazar, Grober, Westhaus, Adrian, Merjane, Jessica, Crawford, Michael, McCaughan, Geoffrey W., Unzu, Carmen, González-Aseguinolaza, Gloria, Alexander, Ian E., Pulitano, Carlo, Lisowski, Leszek

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Characterization of the humanized FRG mouse model and development of an AAV-LK03 variant with improved liver lobular biodistribution by Cabanes-Creus, Marti, Navarro, Renina Gale, Liao, Sophia H.Y., Scott, Suzanne, Carlessi, Rodrigo, Roca-Pinilla, Ramon, Knight, Maddison, Baltazar, Grober, Zhu, Erhua, Jones, Matthew, Denisenko, Elena, Forrest, Alistair R.R., Alexander, Ian E., Tirnitz-Parker, Janina E.E., Lisowski, Leszek

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Restoring the natural tropism of AAV2 vectors for human liver by Cabanes-Creus, Marti, Hallwirth, Claus V, Westhaus, Adrian, Ng, Boaz H, Liao, Sophia H Y, Zhu, Erhua, Navarro, Renina Gale, Baltazar, Grober, Drouyer, Matthieu, Scott, Suzanne, Logan, Grant J, Santilli, Giorgia, Bennett, Antonette, Ginn, Samantha L, McCaughan, Geoff, Thrasher, Adrian J, Agbandje-McKenna, Mavis, Alexander, Ian E, Lisowski, Leszek

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Novel human liver-tropic AAV variants define transferable domains that markedly enhance the human tropism of AAV7 and AAV8 by Cabanes-Creus, Marti, Navarro, Renina Gale, Zhu, Erhua, Baltazar, Grober, Liao, Sophia H.Y., Drouyer, Matthieu, Amaya, Anais K., Scott, Suzanne, Nguyen, Loan Hanh, Westhaus, Adrian, Hebben, Matthias, Wilson, Laurence O.W., Thrasher, Adrian J., Alexander, Ian E., Lisowski, Leszek

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Attenuation of Heparan Sulfate Proteoglycan Binding Enhances In Vivo Transduction of Human Primary Hepatocytes with AAV2 by Cabanes-Creus, Marti, Westhaus, Adrian, Navarro, Renina Gale, Baltazar, Grober, Zhu, Erhua, Amaya, Anais K., Liao, Sophia H.Y., Scott, Suzanne, Sallard, Erwan, Dilworth, Kimberley L., Rybicki, Arkadiusz, Drouyer, Matthieu, Hallwirth, Claus V., Bennett, Antonette, Santilli, Giorgia, Thrasher, Adrian J., Agbandje-McKenna, Mavis, Alexander, Ian E., Lisowski, Leszek

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Development of new adeno-associated virus capsid variants for targeted gene delivery to human cardiomyocytes by Kok, Cindy Y., Tsurusaki, Shinya, Cabanes-Creus, Marti, Igoor, Sindhu, Rao, Renuka, Skelton, Rhys, Liao, Sophia H.Y., Ginn, Samantha L., Knight, Maddison, Scott, Suzanne, Mietzsch, Mario, Fitzsimmons, Rebecca, Miller, Jessica, Mohamed, Tamer M.A., McKenna, Robert, Chong, James J.H., Hill, Adam P., Hudson, James E., Alexander, Ian E., Lisowski, Leszek, Kizana, Eddy

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Single amino acid insertion allows functional transduction of murine hepatocytes with human liver tropic AAV capsids by Cabanes-Creus, Marti, Navarro, Renina Gale, Liao, Sophia H.Y., Baltazar, Grober, Drouyer, Matthieu, Zhu, Erhua, Scott, Suzanne, Luong, Clement, Wilson, Laurence O.W., Alexander, Ian E., Lisowski, Leszek

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Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality by Cabanes-Creus, Marti, Ginn, Samantha L, Amaya, Anais K, Liao, Sophia H Y, Westhaus, Adrian, Hallwirth, Claus V, Wilmott, Patrick, Ward, Jason, Dilworth, Kimberley L, Santilli, Giorgia, Rybicki, Arkadiusz, Nakai, Hiroyuki, Thrasher, Adrian J, Filip, Adrian C, Alexander, Ian E, Lisowski, Leszek

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Efficient in vivo editing of OTC-deficient patient-derived primary human hepatocytes by Ginn, Samantha L., Amaya, Anais K., Liao, Sophia H.Y., Zhu, Erhua, Cunningham, Sharon C., Lee, Michael, Hallwirth, Claus V., Logan, Grant J., Tay, Szun S., Cesare, Anthony J., Pickett, Hilda A., Grompe, Markus, Dilworth, Kimberley, Lisowski, Leszek, Alexander, Ian E.

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