Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development by Sun, Daqing, Li, Zhihong, Rew, Yosup, Gribble, Michael, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chen, Xiaoqi, Chow, David, Deignan, Jeffrey, Duquette, Jason, Eksterowicz, John, Fisher, Benjamin, Fox, Brian M, Fu, Jiasheng, Gonzalez, Ana Z, Gonzalez-Lopez De Turiso, Felix, Houze, Jonathan B, Huang, Xin, Jiang, Min, Jin, Lixia, Kayser, Frank, Liu, Jiwen (Jim), Lo, Mei-Chu, Long, Alexander M, Lucas, Brian, McGee, Lawrence R, McIntosh, Joel, Mihalic, Jeff, Oliner, Jonathan D, Osgood, Tao, Peterson, Matthew L, Roveto, Philip, Saiki, Anne Y, Shaffer, Paul, Toteva, Maria, Wang, Yingcai, Wang, Yu Chung, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Yu, Ming, Zhao, Xiaoning, Zhou, Jing, Zhu, Jiang, Olson, Steven H, Medina, Julio C

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Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1 by Xiong, Yumei, Swaminath, Gayathri, Cao, Qiong, Yang, Li, Guo, Qi, Salomonis, Heather, Lu, Jenny, Houze, Jonathan B., Dransfield, Paul J., Wang, Yingcai, Liu, Jiwen (Jim), Wong, Simon, Schwandner, Ralf, Steger, Franziska, Baribault, Helene, Liu, Lily, Coberly, Suzanne, Miao, Lynn, Zhang, Jane, Lin, Daniel C.-H., Schwarz, Margrit

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Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles by Wang, Yingcai, Liu, Jiwen (Jim), Dransfield, Paul J, Zhu, Liusheng, Wang, Zhongyu, Du, Xiaohui, Jiao, Xianyun, Su, Yongli, Li, An-rong, Brown, Sean P, Kasparian, Annie, Vimolratana, Marc, Yu, Ming, Pattaropong, Vatee, Houze, Jonathan B, Swaminath, Gayathri, Tran, Thanhvien, Nguyen, Khanh, Guo, Qi, Zhang, Jane, Zhuang, Run, Li, Frank, Miao, Lynn, Bartberger, Michael D, Correll, Tiffany L, Chow, David, Wong, Simon, Luo, Jian, Lin, Daniel C.-H, Medina, Julio C

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Discovery and optimization of N-(3-(1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yloxy)phenyl)benzenesulfonamides as novel GPR119 agonists by Yu, Ming, Ken Zhang, Jian, Wang, Yingcai, Zhu, Jiang, Kayser, Frank, Medina, Julio C, Siegler, Karen, Conn, Marion, Shan, Bei, Grillo, Mark P, Coward, Peter, Jim Liu, Jiwen

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Discovery of the imidazole-derived GPR40 agonist AM-3189 by Ma, Zhihua, Lin, Daniel C.-H., Sharma, Rajiv, Liu, Jinqian, Zhu, Liusheng, Li, An-Rong, Kohn, Todd, Wang, Yingcai, Liu, Jiwen (Jim), Bartberger, Michael D., Medina, Julio C., Zhuang, Run, Li, Frank, Zhang, Jane, Luo, Jian, Wong, Simon, Tonn, George R., Houze, Jonathan B.

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Discovery and optimization of arylsulfonyl 3-(pyridin-2-yloxy)anilines as novel GPR119 agonists by Zhang, Jian (Ken), Li, An-Rong, Yu, Ming, Wang, Yingcai, Zhu, Jiang, Kayser, Frank, Medina, Julio C., Siegler, Karen, Conn, Marion, Shan, Bei, Grillo, Mark P., Eksterowicz, John, Coward, Peter, Liu, Jiwen (Jim)

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Optimization of GPR40 Agonists for Type 2 Diabetes by Liu, Jiwen (Jim), Wang, Yingcai, Ma, Zhihua, Schmitt, Mike, Zhu, Liusheng, Brown, Sean P, Dransfield, Paul J, Sun, Ying, Sharma, Rajiv, Guo, Qi, Zhuang, Run, Zhang, Jane, Luo, Jian, Tonn, George R, Wong, Simon, Swaminath, Gayathri, Medina, Julio C, Lin, Daniel C.-H, Houze, Jonathan B

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Discovery and optimization of 5-(2-((1-(phenylsulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)oxy)pyridin-4-yl)-1,2,4-oxadiazoles as novel gpr119 agonists by Wang, Yingcai, Yu, Ming, Zhu, Jiang, Zhang, Jian Ken, Kayser, Frank, Medina, Julio C, Siegler, Karen, Conn, Marion, Shan, Bei, Grillo, Mark P, Liu, Jiwen Jim, Coward, Peter

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Optimization beyond AMG 232: Discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein–protein interaction by Wang, Yingcai, Zhu, Jiang, Liu, Jiwen (Jim), Chen, Xiaoqi, Mihalic, Jeff, Deignan, Jeffrey, Yu, Ming, Sun, Daqing, Kayser, Frank, McGee, Lawrence R., Lo, Mei-Chu, Chen, Ada, Zhou, Jing, Ye, Qiuping, Huang, Xin, Long, Alexander M., Yakowec, Peter, Oliner, Jonathan D., Olson, Steven H., Medina, Julio C.

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Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2–p53 Interaction by Yu, Ming, Wang, Yingcai, Zhu, Jiang, Bartberger, Michael D, Canon, Jude, Chen, Ada, Chow, David, Eksterowicz, John, Fox, Brian, Fu, Jiasheng, Gribble, Michael, Huang, Xin, Li, Zhihong, Liu, Jiwen (Jim), Lo, Mei-chu, McMinn, Dustin, Oliner, Jonathan D, Osgood, Tao, Rew, Yosup, Saiki, Anne Y, Shaffer, Paul, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Olson, Steven H, Medina, Julio C, Sun, Daqing

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Improving the Pharmacokinetics of GPR40/FFA1 Full Agonists by Du, Xiaohui, Dransfield, Paul J, Lin, Daniel C.-H, Wong, Simon, Wang, Yingcai, Wang, Zhongyu, Kohn, Todd, Yu, Ming, Brown, Sean P, Vimolratana, Marc, Zhu, Liusheng, Li, An-Rong, Su, Yongli, Jiao, Xianyun, Liu, Jiwen (Jim), Swaminath, Gayathri, Tran, Thanhvien, Luo, Jian, Zhuang, Run, Zhang, Jane, Guo, Qi, Li, Frank, Connors, Richard, Medina, Julio C, Houze, Jonathan B

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Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonism by Wang, Yingcai, Fu, Zice, Schmitt, Michael, Wang, Xuemei, Shen, Wang, Rickel, Erika, Martin, Tod, Budelsky, Alison, Marshall, Derek, Collins, Tassie, Tang, H. Lucy, Medina, Julio C., Liu, Jiwen (Jim)

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Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP by Johnson, Michael G, Liu, Jim Jiwen, Li, An-Rong, van Lengerich, Bettina, Wang, Sophie, Medina, Julio C, Collins, Tassie L, Danao, Jay, Seitz, Lisa, Willee, Angela, D'Souza, Warren, Budelsky, Alison L, Fan, Peter W, Wong, Simon G W

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Optimization of phenylacetic acid derivatives for balanced CRTH2 and DP dual antagonists by Liu, Jiwen (Jim), Wang, Yingcai, Johnson, Michael G., Li, An-Rong, Shen, Wang, Wang, Xuemei, Su, Yongli, Brown, Matthew, Van Lengerich, Bettina, Rickel, Erika, Martin, Tod, Budelsky, Alison, Seitz, Lisa, Danao, Jay, Tang, H. Lucy, Collins, Tassie, Medina, Julio C.

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Aminopyrazole–Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies by Yu, Ming, Lizarzaburu, Mike, Motani, Alykhan, Fu, Zice, Du, Xiaohui, Liu, Jiwen (Jim), Jiao, Xianyun, Lai, SuJen, Fan, Peter, Fu, Angela, Liu, Qingxiang, Murakoshi, Michiko, Nara, Futoshi, Oda, Kozo, Okuyama, Ryo, Reagan, Jeff D, Watanabe, Nobuaki, Yamazaki, Mami, Xiong, Yumei, Zhang, Ying, Zhuang, Run, Lin, Daniel C.-H, Houze, Jonathan B, Medina, Julio C, Li, Leping

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Benzodiazepinone Derivatives as CRTH2 Antagonists by Liu, Jiwen (Jim), Cheng, Alan C, Tang, H. Lucy, Medina, Julio C

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Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD2 receptors CRTH2 and DP by Johnson, Michael G., Liu, Jim (Jiwen), Li, An-Rong, van Lengerich, Bettina, Wang, Sophie, Medina, Julio C., Collins, Tassie L., Danao, Jay, Seitz, Lisa, Willee, Angela, D’Souza, Warren, Budelsky, Alison L., Fan, Peter W., Wong, Simon G.W.

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Biolink Model: A universal schema for knowledge graphs in clinical, biomedical, and translational science by Moxon, Sierra A. T., Bruskiewich, Richard, Dancik, Vlado, Dumontier, Michel, Fecho, Karamarie, Putman, Tim, Qin, Guangrong, Ramsey, Stephen A., Soman, Karthik, Thessen, Anne E., Haendel, Melissa A., Mungall, Christopher J., Ahalt, Stanley C., Alden, John, Alkanaq, Ahmed, Avila, Ricardo, Baumgartner, Andrew, Belhu, Basazin, Brandon, Namdi, Burtt, Noel, Byrd, William, Callaghan, Jackson, Cano, Marco Alvarado, Celebi, Remzi, Champion, James, Chen, Zhehuan, Chung, Lawrence, Cohen, Kevin, Costanzo, Maria, Dai, Cheng, Dančík, Vlado, Dougherty, Jennifer, Gardner, Vicki, Glen, Amy, Goel, Prateek, Gormley, Joseph, Greyber, Alon, Haaland, Perry, Hanspers, Kristina, He, Kaiwen, Hinderer, Eugene W., Hubal, Robert, Issabekova, Tursynay, Jarrell, Matthew, Jenkins, Lindsay, Kang, Jimin, Kim, Keum Joo, Knowles, Michael, Koesterer, Ryan, Korn, Daniel, Koslicki, David, Krishnamurthy, Ashok, Kvarfordt, Lindsey, Leigh, Margaret, Magis, Andrew, Mamidi, Tarun, Mantilla, Michelle, Massung, Jeffrey, Mauldin, Denise, McMurry, Julie, Mease, Philip, Mendoza, Luis, Mersmann, Marian, Muller, Sandrine, Muluka, Arun Teja, Osborne, John, Owen, Phil, Patton, Michael, Peden, David B., Peene, R. Carter, Pfaff, Emily, Price, Guthrie, Raj, Shruti, Reilly, Jason, Roach, Jared, Roper, Ryan T., Rosenblatt, Greg, Rubin, Irit, Scott, Erik, Sharma, Priya, Shrestha, Manil, Sinha, Meghamala, Southall, Noel, Stillwell, Lisa, Strasser, Michael " Michi", Tinglin, Jillian, Tropsha, Alexander, Vaidya, Gaurav, Viola, Adam, Wang, Max, Weber, Rosina, Wei, Qi, Whitlock, Jordan, Williams, Mark D., Xin, Jiwen Kevin, Xu, Hao, Xu, Colleen, Yao, Yao, Zhou, Eric, Zisk, Tom

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Progress toward a universal biomedical data translator by Thessen, Anne E., Roper, Ryan T., Southall, Noel, Ta, Casey, Xu, Hao, Byrd, William, Dančík, Vlado, Duby, Marc P., Dumontier, Michel, Glusman, Gustavo, Hinderer, Eugene W., Johs, Adam, Su, Andrew I., Qin, Guangrong, Zhu, Qian, Dougherty, Jennifer, Magis, Andrew, Smith, Brett, Chen, Zhehuan, Azevedo, Ricardo De Miranda, Lee, Jay, Weng, Chunhua, Yilmaz, Arif, Santos, Eugene, Yakaboski, Chase, Deutsch, Eric, Koslicki, David, Kvarfordt, Lindsey, Ma, Chunyu, Wood, Erica, Roach, Jared, Williams, Andrew, Gormley, Joseph, Zisk, Tom, Hoatlin, Maureen, Pico, Alexander, Riutta, Anders, Xu, Colleen, Ahalt, Stanley C., Knowles, Michael, Krishnamurthy, Ashok, Mandal, Meisha, Peden, David B., Cox, Steven, Vaidya, Gaurav, Wang, Max, Alkanaq, Ahmed, Costanzo, Maria, Koesterer, Ryan, Flannick, Jason, Kluge, Alexandria, Strasser, Michael “ Michi”, Chung, Lawrence, Kang, Jimin, Mantilla, Michelle, Muller, Sandrine, Persaud, Bria, Wei, Qi, Dai, Cheng, Duvvuri, Venkata, Mauldin, Denise, Korn, Daniel, Mesbah, Abrar, Tropsha, Alexander, Mersmann, Marian, Morton, Kenny, Lin, Jason, Avila, Ricardo, Wu, Chunlei, Cano, Marco Alvarado, Issabekova, Tursynay, McMurry, Julie, Cohen, Kevin, He, Kaiwen, Mamidi, Tarun, Might, Matthew, Osborne, John, Tran‐Nguyen, Thi, Crouse, Andrew, Belhu, Basazin, Stillwell, Lisa, Grotthuss, Marcin, Wang, Patrick, Zhou, Xinghua, Sinha, Meghamala, Raj, Shruti, Peene, R. Carter, McClelland, Jason, Leigh, Margaret, Zhou, Eric, Amin, Nada, Fehrmann, Nathaniel, Foksinska, Aleksandra M., Jenkins, Lindsay, He, Kaiwen, Jarrell, Matthew, Pollard, Elizabeth, Rucka, Sienna, Tinglin, Jillian, Zheng, Marissa

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