Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds by Sakatis, Melanie Z, Reese, Melinda J, Harrell, Andrew W, Taylor, Maxine A, Baines, Ian A, Chen, Liangfu, Bloomer, Jackie C, Yang, Eric Y, Ellens, Harma M, Ambroso, Jeffrey L, Lovatt, Cerys A, Ayrton, Andrew D, Clarke, Stephen E

Get full text

Increased Constitutive c-Jun N-terminal Kinase Signaling in Mice Lacking Glutathione S-Transferase Pi by Elsby, Robert, Kitteringham, Neil R, Goldring, Christopher E, Lovatt, Cerys A, Chamberlain, Mark, Henderson, Colin J, Wolf, C Roland, Park, B Kevin

Get full text

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity by Sison-Young, Rowena L., Lauschke, Volker M., Johann, Esther, Alexandre, Eliane, Antherieu, Sébastien, Aerts, Hélène, Gerets, Helga H. J., Labbe, Gilles, Hoët, Delphine, Dorau, Martina, Schofield, Christopher A., Lovatt, Cerys A., Holder, Julie C., Stahl, Simone H., Richert, Lysiane, Kitteringham, Neil R., Jones, Robert P., Elmasry, Mohamed, Weaver, Richard J., Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Chris E., Park, B. Kevin

Get full text

Determination of drug concentrations using dried blood spots: investigation of blood sampling and collection techniques in Crl:CD(SD) rats by Stokes, Alan H, Moose, Tammy A, Parry, Simon P, Barfield, Matthew, Lovatt, Cerys A, Dopson, Wesley J, Melich, David, Overvold, Carol R, Gade, Sonya D, Spooner, Neil

Get full text

Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes by Goldring, Chris E. P, Kitteringham, Neil R, Jenkins, Rosalind, Lovatt, Cerys A, Randle, Laura E, Abdullah, Azman, Owen, Andrew, Liu, Xiaoping, Butler, Philip J, Williams, Dominic P, Metcalfe, Peter, Berens, Christian, Hillen, Wolfgang, Foster, Brian, Simpson, Alec, McLellan, Lesley, Park, B. Kevin

Get full text

Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes by Goldring, Chris E P, Kitteringham, Neil R, Jenkins, Rosalind, Lovatt, Cerys A

Get full text

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity by Sison-Young, Rowena L., Lauschke, Volker M., Johann, Esther, Alexandre, Eliane, Antherieu, Sébastien, Aerts, Hélène, Gerets, Helga H. J., Labbe, Gilles, Hoët, Delphine, Dorau, Martina, Schofield, Christopher A., Lovatt, Cerys A., Holder, Julie C., Stahl, Simone H., Richert, Lysiane, Kitteringham, Neil R., Jones, Robert P., Elmasry, Mohamed, Weaver, Richard J., Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Chris E., Park, B. Kevin

Get full text

Design, Synthesis, and Characterization of I‑BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate by Humphreys, Philip G, Atkinson, Stephen J, Bamborough, Paul, Bit, Rino A, Chung, Chun-wa, Craggs, Peter D, Cutler, Leanne, Davis, Rob, Ferrie, Alan, Gong, GangLi, Gordon, Laurie J, Gray, Matthew, Harrison, Lee A, Hayhow, Thomas G, Haynes, Andrea, Henley, Nick, Hirst, David J, Holyer, Ian D, Lindon, Matthew J, Lovatt, Cerys, Lugo, David, McCleary, Scott, Molnar, Judit, Osmani, Qendresa, Patten, Chris, Preston, Alex, Rioja, Inmaculada, Seal, Jonathan T, Smithers, Nicholas, Sun, Fenglai, Tang, Dalin, Taylor, Simon, Theodoulou, Natalie H, Thomas, Clare, Watson, Robert J, Wellaway, Christopher R, Zhu, Linrong, Tomkinson, Nicholas C. O, Prinjha, Rab K

Get full text

Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies by Scarfe, Lauren, Brillant, Nathalie, Kumar, J. Dinesh, Ali, Noura, Alrumayh, Ahmed, Amali, Mohammed, Barbellion, Stephane, Jones, Vendula, Niemeijer, Marije, Potdevin, Sophie, Roussignol, Gautier, Vaganov, Anatoly, Barbaric, Ivana, Barrow, Michael, Burton, Neal C., Connell, John, Dazzi, Francesco, Edsbagge, Josefina, French, Neil S., Holder, Julie, Hutchinson, Claire, Jones, David R., Kalber, Tammy, Lovatt, Cerys, Lythgoe, Mark F., Patel, Sara, Patrick, P. Stephen, Piner, Jacqueline, Reinhardt, Jens, Ricci, Emanuelle, Sidaway, James, Stacey, Glyn N., Starkey Lewis, Philip J., Sullivan, Gareth, Taylor, Arthur, Wilm, Bettina, Poptani, Harish, Murray, Patricia, Goldring, Chris E. P., Park, B. Kevin

Get full text

Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I‑BET787 by Hirst, David J., Bamborough, Paul, Al-Mahdi, Niam, Angell, Davina C., Barnett, Heather A., Baxter, Andrew, Bit, Rino A., Brown, Jack A., Chung, Chun-wa, Craggs, Peter D., Davis, Robert P., Demont, Emmanuel H., Ferrie, Alan, Gordon, Laurie J., Harada, Isobel, Ho, Tim C. T., Holyer, Ian D., Hooper-Greenhill, Edward, Jones, Katherine L., Lindon, Matthew J., Lovatt, Cerys, Lugo, David, Maller, Claire, McGonagle, Grant, Messenger, Cassie, Mitchell, Darren J., Pascoe, David D., Patel, Vipulkumar K., Patten, Christopher, Poole, Darren L., Shah, Rishi R., Rioja, Inmaculada, Stafford, Kayleigh A. J., Tape, Daniel, Taylor, Simon, Theodoulou, Natalie H., Tomlinson, Laura, Wall, Ian D., Wellaway, Christopher R., White, Gemma, Prinjha, Rab K., Humphreys, Philip G.

Get full text

Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats by Richert, Lysiane, Baze, Audrey, Parmentier, Céline, Gerets, Helga H.J., Sison-Young, Rowena, Dorau, Martina, Lovatt, Cerys, Czich, Andreas, Goldring, Christopher, Park, B. Kevin, Juhila, Satu, Foster, Alison J., Williams, Dominic P.

Get full text

Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol-induced toxicity in the liver by Kitteringham, Neil R., Powell, Helen, Jenkins, Rosalind E., Hamlett, Jane, Lovatt, Cerys, Elsby, Robert, Henderson, Colin J., Wolf, C. Roland, Pennington, Stephen R., Park, B. Kevin

Get full text