AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance by O'Hare, Thomas, Shakespeare, William C., Zhu, Xiaotian, Eide, Christopher A., Rivera, Victor M., Wang, Frank, Adrian, Lauren T., Zhou, Tianjun, Huang, Wei-Sheng, Xu, Qihong, Metcalf, Chester A., Tyner, Jeffrey W., Loriaux, Marc M., Corbin, Amie S., Wardwell, Scott, Ning, Yaoyu, Keats, Jeffrey A., Wang, Yihan, Sundaramoorthi, Raji, Thomas, Mathew, Zhou, Dong, Snodgrass, Joseph, Commodore, Lois, Sawyer, Tomi K., Dalgarno, David C., Deininger, Michael W.N., Druker, Brian J., Clackson, Tim

Get full text

Identification of Src-specific phosphorylation site on focal adhesion kinase: Dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavi... by BRUNTON, Valerie G, AVIZIENYTE, Egle, FINCHAM, Valerie J, SERRELS, Bryan, METCALF, Chester A, SAWYER, Tomi K, FRAME, Margaret C

Get full text

Activity of Dual SRC-ABL Inhibitors Highlights the Role of BCR/ABL Kinase Dynamics in Drug Resistance by Azam, Mohammad, Nardi, Valentina, Shakespeare, William C., Metcalf, Chester A., Bohacek, Regine S., Wang, Yihan, Sundaramoorthi, Raji, Sliz, Piotr, Veach, Darren R., Bornmann, William G., Clarkson, Bayard, Dalgarno, David C., Sawyer, Tomi K., Daley, George Q.

Get full text

Antiangiogenic and antitumor effects of src inhibition in ovarian carcinoma by HAN, Liz Y, LANDEN, Charles N, SHAKESPEARE, William C, YIHAN WANG, SUNDARAMOORTH, Raji, METCALF, Chester A, DALGARNO, David C, SAWYER, Tomi K, GALLICK, Gary E, SOOD, Anil K, TREVINO, Jose G, HALDER, Jyotsnabaran, LIN, Yvonne G, KAMAT, Aparna A, KIM, Tae-Jin, MERRITT, William M, COLEMAN, Robert L, GERSHENSON, David M

Get full text

AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogate... by Summy, Justin M, Trevino, Jose G, Lesslie, Donald P, Baker, Cheryl H, Shakespeare, William C, Wang, Yihan, Sundaramoorthi, Raji, Metcalf, 3rd, Chester A, Keats, Jeffrey A, Sawyer, Tomi K, Gallick, Gary E

Get full text

Src Inhibitors in Metastatic Bone Disease by Boyce, Brendan F, Xing, Lianping, Yao, Zhenqiang, Yamashita, Teruhito, Shakespeare, William C, Wang, Yihan, Metcalf, 3rd, Chester A, Sundaramoorthi, Raji, Dalgarno, David C, Iuliucci, John D, Sawyer, Tomi K

Get full text

Future Anti-Catabolic Therapeutic Targets in Bone Disease by BOYCE, BRENDAN F., XING, LIANPING, YAO, ZHENQIANG, SHAKESPEARE, WILLIAM C., WANG, YIHAN, METCALF III, CHESTER A., SUNDARAMOORTHI, RAJI, DALGARNO, DAVID C., IULIUCCI, JOHN D., SAWYER, TOMI K.

Get full text

Structure-based design of novel nonpeptide inhibitors of the Src SH2 domain: Phosphotyrosine mimetics exploiting multifunctional group replacement chemistry by Sundaramoorthi, Raji, Kawahata, Noriyuki, Yang, Michael G., Shakespeare, William C., Metcalf III, Chester A., Wang, Yihan, Merry, Taylor, Eyermann, Charles J., Bohacek, Regine S., Narula, Surinder, Dalgarno, David C., Sawyer, Tomi K.

Get full text

Structural Basis of Src Tyrosine Kinase Inhibition with a New Class of Potent and Selective Trisubstituted Purine-based Compounds by Dalgarno, David, Stehle, Thilo, Narula, Surinder, Schelling, Pierre, Rose van Schravendijk, Marie, Adams, Susan, Andrade, Lawrence, Keats, Jeff, Ram, Mary, Jin, Lei, Grossman, Trudy, MacNeil, Ian, Metcalf III, Chester, Shakespeare, William, Wang, Yihan, Keenan, Terry, Sundaramoorthi, Raji, Bohacek, Regine, Weigele, Manfred, Sawyer, Tomi

Get full text

Structure-Based Design of an Osteoclast-Selective, Nonpeptide Src Homology 2 Inhibitor with in vivo Antiresorptive Activity by Shakespeare, William, Yang, Michael, Bohacek, Regine, Cerasoli, Franklin, Stebbins, Karin, Sundaramoorthi, Raji, Azimioara, Mihai, Vu, Chi, Pradeepan, Selvi, Metcalf, Chester, Haraldson, Chad, Merry, Taylor, Dalgarno, David, Narula, Surinder, Hatada, Marcos, Lu, Xiaode, van Schravendijk, Marie Rose, Adams, Susan, Violette, Shelia, Smith, Jeremy, Guan, Wei, Bartlett, Catherine, Herson, Jay, Iuliucci, John, Weigele, Manfred, Sawyer, Tomi

Get full text

X-ray Structure of Citrate Bound to Src SH2 Leads to a High-Affinity, Bone-Targeted Src SH2 Inhibitor by Bohacek, Regine S, Dalgarno, David C, Hatada, Marcos, Jacobsen, Virginia A, Lynch, Berkley A, Macek, Karina J, Merry, Taylor, Metcalf, Chester A, Narula, Surinder S, Sawyer, Tomi K, Shakespeare, William C, Violette, Shelia M, Weigele, Manfred

Get full text