Optimization of Selectivity and Pharmacokinetic Properties of Salt‑Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312 by Temal-Laib, Taouès, Peixoto, Christophe, Desroy, Nicolas, De Lemos, Elsa, Bonnaterre, Florence, Bienvenu, Natacha, Picolet, Olivier, Sartori, Eric, Bucher, Denis, López-Ramos, Miriam, Roca Magadán, Carlos, Laenen, Wendy, Flower, Thomas, Mollat, Patrick, Bugaud, Olivier, Touitou, Robert, Pereira Fernandes, Anna, Lavazais, Stephanie, Monjardet, Alain, Borgonovi, Monica, Gosmini, Romain, Brys, Reginald, Amantini, David, De Vos, Steve, Andrews, Martin

Get full text

Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease by de Andrade, Peterson, Mantoani, Susimaire P., Gonçalves Nunes, Paulo Sérgio, Magadán, Carlos Roca, Pérez, Concepción, Xavier, Danilo Jordão, Hojo, Elza Tiemi Sakamoto, Campillo, Nuria E., Martínez, Ana, Carvalho, Ivone

Get full text

Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases by Peixoto, Christophe, Joncour, Agnes, Temal-Laib, Taouès, Tirera, Amynata, Dos Santos, Aurélie, Jary, Hélène, Bucher, Denis, Laenen, Wendy, Pereira Fernandes, Anna, Lavazais, Stephanie, Delachaume, Carole, Merciris, Didier, Saccomani, Corinne, Drennan, Michael, López-Ramos, Miriam, Wakselman, Emanuelle, Dupont, Sonia, Borgonovi, Monica, Roca Magadan, Carlos, Monjardet, Alain, Brys, Reginald, De Vos, Steve, Andrews, Martin, Jimenez, Juan-Miguel, Amantini, David, Desroy, Nicolas

Get full text