Discovery of novel isothiazole inhibitors of the TrkA kinase: Structure–activity relationship, computer modeling, optimization, and identification of highly potent antagonists by Lippa, Blaise, Morris, Joel, Corbett, Matthew, Kwan, Tricia A., Noe, Mark C., Snow, Sheri L., Gant, Thomas G., Mangiaracina, Melchiorra, Coffey, Heather A., Foster, Barbara, Knauth, Elisabeth A., Wessel, Matthew D.

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