4B.02. Pharmacogenetic GWAS meta-analysis of response to antihypertensive drugs by Warren, Helen, Sever, Peter, Poulter, Neil, Stanton, Alice, Caulfield, Mark, Munroe, Patricia

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Whole-genome sequencing of patients with rare diseases in a national health system by Turro, Ernest, Astle, William, Megy, Karyn, Gräf, Stefan, Greene, Daniel, Shamardina, Olga, Allen, Hana Lango, Sanchis-Juan, Alba, Frontini, Mattia, Thys, Chantal, Stephens, Jonathan, Mapeta, Rutendo, Burren, Oliver, Downes, Kate, Haimel, Matthias, Tuna, Salih, Deevi, Sri, Aitman, Timothy, Bennett, David, Calleja, Paul, Carss, Keren, Caulfield, Mark, Chinnery, Patrick, Dixon, Peter, Gale, Daniel, James, Roger, Koziell, Ania, Laffan, Michael, Levine, Adam, Maher, Eamonn, Markus, Hugh, Morales, Joannella, Morrell, Nicholas, Mumford, Andrew, Ormondroyd, Elizabeth, Rankin, Stuart, Rendon, Augusto, Richardson, Sylvia, Roberts, Irene, Roy, Noemi, Saleem, Moin, Smith, Kenneth, Stark, Hannah, Tan, Rhea, Themistocleous, Andreas, Thrasher, Adrian, Watkins, Hugh, Webster, Andrew, Wilkins, Martin, Williamson, Catherine, Whitworth, James, Humphray, Sean, Bentley, David, Abbs, Stephen, Abulhoul, Lara, Adlard, Julian, Ahmed, Munaza, Alachkar, Hana, Allsup, David, Almeida-King, Jeff, Ancliff, Philip, Antrobus, Richard, Armstrong, Ruth, Arno, Gavin, Ashford, Sofie, Attwood, Anthony, Aurora, Paul, Babbs, Christian, Bacchelli, Chiara, Bakchoul, Tamam, Banka, Siddharth, Bariana, Tadbir, Barwell, Julian, Batista, Joana, Baxendale, Helen, Beales, Phil, Bierzynska, Agnieszka, Biss, Tina, Bitner-Glindzicz, Maria, Black, Graeme, Bleda, Marta, Blesneac, Iulia, Bockenhauer, Detlef, Bogaard, Harm, Bourne, Christian, Boyce, Sara, Bradley, John, Bragin, Eugene, Breen, Gerome, Brennan, Paul, Brewer, Carole, Brown, Matthew, Browning, Andrew, Browning, Michael, Buchan, Rachel, Buckland, Matthew, Bueser, Teofila, Diz, Carmen Bugarin, Burn, John, Burns, Siobhan

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Whole-genome sequencing of patients with rare diseases in a national health system by Turro, Ernest, Astle, William, Megy, Karyn, Gräf, Stefan, Greene, Daniel, Shamardina, Olga, Allen, Hana Lango, Sanchis-Juan, Alba, Frontini, Mattia, Thys, Chantal, Stephens, Jonathan, Mapeta, Rutendo, Burren, Oliver, Downes, Kate, Haimel, Matthias, Tuna, Salih, Deevi, Sri, Aitman, Timothy, Bennett, David, Calleja, Paul, Carss, Keren, Caulfield, Mark, Chinnery, Patrick, Dixon, Peter, Gale, Daniel, James, Roger, Koziell, Ania, Laffan, Michael, Levine, Adam, Maher, Eamonn, Markus, Hugh, Morales, Joannella, Morrell, Nicholas, Mumford, Andrew, Ormondroyd, Elizabeth, Rankin, Stuart, Rendon, Augusto, Richardson, Sylvia, Roberts, Irene, Roy, Noemi, Saleem, Moin, Smith, Kenneth, Stark, Hannah, Tan, Rhea, Themistocleous, Andreas, Thrasher, Adrian, Watkins, Hugh, Webster, Andrew, Wilkins, Martin, Williamson, Catherine, Whitworth, James, Humphray, Sean, Bentley, David, Abbs, Stephen, Abulhoul, Lara, Adlard, Julian, Ahmed, Munaza, Alachkar, Hana, Allsup, David, Almeida-King, Jeff, Ancliff, Philip, Antrobus, Richard, Armstrong, Ruth, Arno, Gavin, Ashford, Sofie, Attwood, Anthony, Aurora, Paul, Babbs, Christian, Bacchelli, Chiara, Bakchoul, Tamam, Banka, Siddharth, Bariana, Tadbir, Barwell, Julian, Batista, Joana, Baxendale, Helen, Beales, Phil, Bierzynska, Agnieszka, Biss, Tina, Bitner-Glindzicz, Maria, Black, Graeme, Bleda, Marta, Blesneac, Iulia, Bockenhauer, Detlef, Bogaard, Harm, Bourne, Christian, Boyce, Sara, Bradley, John, Bragin, Eugene, Breen, Gerome, Brennan, Paul, Brewer, Carole, Brown, Matthew, Browning, Andrew, Browning, Michael, Buchan, Rachel, Buckland, Matthew, Bueser, Teofila, Diz, Carmen Bugarin, Burn, John, Burns, Siobhan

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Common Variants in Genes Underlying Monogenic Hypertension and Hypotension and Blood Pressure in the General Population by Tobin, Martin D, Tomaszewski, Maciej, Braund, Peter S, Hajat, Cother, Raleigh, Stuart M, Palmer, Thomas M, Caulfield, Mark, Burton, Paul R, Samani, Nilesh J

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Angiotensinogen in Human Essential Hypertension by Caulfield, Mark, Lavender, Paul, Newell-Price, John, Kamdar, Sejal, Farrall, Martin, Clark, Adrian J.L

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Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium by Shah, Tina, Engmann, Jorgen, Dale, Caroline, Shah, Sonia, White, Jon, Giambartolomei, Claudia, McLachlan, Stela, Zabaneh, Delilah, Cavadino, Alana, Finan, Chris, Wong, Andrew, Amuzu, Antoinette, Ong, Ken, Gaunt, Tom, Holmes, Michael V, Warren, Helen, Swerdlow, Daniel I, Davies, Teri-Louise, Drenos, Fotios, Cooper, Jackie, Sofat, Reecha, Caulfield, Mark, Ebrahim, Shah, Lawlor, Debbie A, Talmud, Philippa J, Humphries, Steve E, Power, Christine, Hypponen, Elina, Richards, Marcus, Hardy, Rebecca, Kuh, Diana, Wareham, Nicholas, Langenberg, Claudia, Ben-Shlomo, Yoav, Day, Ian N, Whincup, Peter, Morris, Richard, Strachan, Mark W J, Price, Jacqueline, Kumari, Meena, Kivimaki, Mika, Plagnol, Vincent, Dudbridge, Frank, Whittaker, John C, Casas, Juan P, Hingorani, Aroon D

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Hypertension due to a deoxycorticosteronesecreting adrenal tumour diagnosed during pregnancy by Pedro Marques, Nicola Tufton, Satya Bhattacharya, Mark Caulfield, Scott A Akker

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Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population by TOBIN, Martin D, RALEIGH, Stuart M, RIDGE, Cathy, CAULFIELD, Mark, SHEEHAN, Nuala A, MUNROE, Patricia B, BURTON, Paul R, SAMANI, Nilesh J, NEWHOUSE, Stephen, BRAUND, Peter, BODYCOTE, Clare, OGLEBY, Jenny, CROSS, Deborah, GRACEY, Jay, HAYES, Saija, SMITH, Terry

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Hypertension by Poulter, Neil R, Prabhakaran, Dorairaj, Caulfield, Mark

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3A.03. Blood-pressure associated variants in NPR3 affect human vascular smooth muscle cells proliferation and calcium response to angiotensin II by Ren, Meixia, Ng, Fu Liang, Witkowska, Kate, Baron, Michael, Townsend-Nicholson, Andrea, Xiao, Qingzhong, Hobbs, Adrian, Ye, Shu, Caulfield, Mark

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COMMON POLYMORPHISMS AT THE CYP17A1 LOCUS ASSOCIATE WITH STEROID PHENOTYPE: SUPPORT FOR BLOOD PRESSURE GWAS SIGNALS AT THIS LOCUS by Diver, Louise A., MacKenzie, Scott M., Fraser, Robert, McManus, Frances, Freel, E. Marie, Alvarez-Madrazo, Samantha, McClure, John D., Friel, Elaine C., Hanley, Neil A., Dominiczak, Anna F., Caulfield, Mark J., Munroe, Patricia B., Connell, John M., Davies, Eleanor

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Identifying High-Risk CLL to Predict Early Relapse after FCR Based Treatment Using Whole Genome Sequencing: First Results from the Genomics England CLL Pilot by Robbe, Pauline, Ridout, Kate, Becq, Jennifer, He, Miao, Clifford, Ruth, Alsolami, Reem, Burns, Adam, Knight, Samantha JL, Oates, Melanie, Howard, Dena, Pettitt, Andrew R., Rendon, Augusto, Popitsch, Niko, Hillmen, Peter, Taylor, Jenny C, Caulfield, Mark, Bentley, David, Turnbull, Clare, Schuh, Anna

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The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol by Samani, Nilesh J., Braund, Peter S., Erdmann, Jeanette, Götz, Anika, Tomaszewski, Maciej, Linsel-Nitschke, Patrick, Hajat, Cother, Mangino, Massimo, Hengstenberg, Christian, Stark, Klaus, Ziegler, Andreas, Caulfield, Mark, Burton, Paul R., Schunkert, Heribert, Tobin, Martin D.

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Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure by Evangelou, Evangelos, Dimou, Niki, Mägi, Reedik, Debette, Stéphanie, Ding, Jun, Li -Gao, Ruifang, Lin, Wei -Yu, Shah, Nabi, Thériault, Sébastien, Verweij, Niek, Amouyel, Philippe, Doney, Alex S.F., Farrall, Martin, Menni, Cristina, Noordam, Raymond, Paré, Guillaume, Stanton, Alice, Thom, Simon, Abecasis, Gonçalo, Amin, Najaf, Arking, Dan E., Batini, Chiara, Bottinger, Erwin P., Campbell, Harry, Ciullo, Marina, Cordell, Heather J., Dörr, Marcus, Elosua, Roberto, Enroth, Stefan, Erzurumluoglu, A. Mesut, Ferreira, Teresa, Giedraitis, Vilmantas, Girotto, Giorgia, Goel, Anuj, Gudnason, Vilmundur, Gyllensten, Ulf, Harris, Tamara B., Hartman, Catharina A., Hottenga, Jouke-Jan, Huffman, Jennifer E., Hwang, Shih-Jen, James, Alan, Johnson, Andrew D., Jula, Antti, Kathiresan, Sekar, Khaw, Kay-Tee, Knekt, Paul, Knight, Joanne, Kristiansson, Kati, Kutalik, Zoltan, Lehtimäki, Terho, Lin, Li, Lindgren, Cecilia M., Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Marten, Jonathan, Milaneschi, Yuri, Morrison, Alanna C., Nelson, Christopher P., Nolte, Ilja M., Nutile, Teresa, Oldehinkel, Albertine J., Padmanabhan, Sandosh, Palmas, Walter, Palotie, Aarno, Penninx, Brenda W.J.H., Nguyen, Quang Tri, Raitakari, Olli T., Rice, Kenneth, Ridker, Paul M., Ried, Janina S., Rose, Lynda M., Rudan, Igor, Salomaa, Veikko, Sarin, Antti-Pekka, Siscovick, David, Sorice, Rossella, Sundström, Johan, Swertz, Morris A., Teumer, Alexander, Traglia, Michela, Tzourio, Christophe, Vaez, Ahmad, van Duijn, Cornelia M., Völker, Uwe, Wild, Sarah H., Yao, Jie, Cucca, Francesco, Hayward, Caroline, Mook-Kanamori, Dennis O., Risch, Lorenz, Scott, Rodney J., Spector, Tim D., Levy, Daniel, Newton-Cheh, Christopher, Brown, Morris J., Psaty, Bruce M., Caulfield, Mark J., Sardari, Soroush, Snieder, Harold

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Authors’ reply to Harding and colleagues, Taylor, Cruickshank, and El Turabi and Payne by Williams, Bryan, Krause, Taryn, Lovibond, Kate, Caulfield, Mark, McCormack, Terry

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Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study by Newhouse, Stephen J., Wallace, Chris, Dobson, Richard, Mein, Charles, Pembroke, Janine, Farrall, Martin, Clayton, David, Brown, Morris, Samani, Nilesh, Dominiczak, Anna, Connell, John M., Webster, John, Lathrop, G. Mark, Caulfield, Mark, Munroe, Patricia B.

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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction by Ntalla, Ioanna, Cartwright, James H., Hall, Amelia Weber, Tucker, Nathan R., Choi, Seung Hoan, Barnes, Michael R., Warren, Helen R., Hayward, Caroline, Marten, Jonathan, Concas, Maria Pina, Boutin, Thibaud, Lima-Costa, Maria Fernanda, Souza, Renan P., Tarazona-Santos, Eduardo, Giedraitis, Vilmantas, Foco, Luisa, Gögele, Martin, Hicks, Andrew A., Cook, James P., Lindgren, Cecilia M., Riaz, Muhammad B., Sinagra, Gianfranco, Ulivi, Sheila, Kähönen, Mika, Mishra, Pashupati P., Nikus, Kjell, Padmanabhan, Sandosh, O’Connell, Jeff R., Aeschbacher, Stefanie, Risch, Lorenz, Thériault, Sébastien, Hutri-Kähönen, Nina, Lehtimäki, Terho, Barnes, Catriona L. K., Joshi, Peter K., Isaacs, Aaron, van Duijn, Cornelia M., Gudnason, Vilmundur, Harris, Tamara B., Nadkarni, Girish N., Correa, Adolfo, Mei, Hao, Wilson, James, Müller-Nurasyid, Martina, Waldenberger, Melanie, Mangino, Massimo, Kääb, Stefan, Schramm, Katharina, Strauch, Konstantin, Cutler, Michael J., Fatkin, Diane, Olesen, Morten, Roden, Dan M., Gustav Smith, J., Biggs, Mary L., Bis, Joshua C., Sotoodehnia, Nona, Pramstaller, Peter P., Ford, Ian, Wouter Jukema, J., Macfarlane, Peter W., Trompet, Stella, Dörr, Marcus, Felix, Stephan B., Weiss, Stefan, Havulinna, Aki S., Jula, Antti, Sääksjärvi, Katri, Rotter, Jerome I., Yao, Jie, Maan, Arie C., Mook-Kanamori, Dennis O., Cucca, Francesco, Lakatta, Edward G., Qian, Yong, Lin, Honghuang, Newton-Cheh, Christopher H., Lunetta, Kathryn L., Murray, Alison D., Stricker, Bruno H., Uitterlinden, André, van den Berg, Marten E., Haessler, Jeffrey, Kooperberg, Charles, Peters, Ulrike, Reiner, Alexander P., Arking, Dan E., Boerwinkle, Eric, Soliman, Elsayed Z., Gogarten, Stephanie M., Kerr, Kathleen F., Laurie, Cathy C., Abdullah Said, M., Yldau van der Ende, M., Ramirez, Julia, Van Duijvenboden, Stefan, Arnar, David O., Thorolfsdottir, Rosa B., Ellinor, Patrick T., Lubitz, Steven A.

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Copy-number analysis from genome sequencing data of 11,754 rare-disease parent-child trios: A model for identifying autosomal recessive human gene knockouts including a novel gene... by Olinger, Eric, Wilson, Ian J., Orr, Sarah, Barroso-Gil, Miguel, Neatu, Ruxandra, Ambrose, John C., Arumugam, Prabhu, Bevers, Roel, Bleda, Marta, Boardman-Pretty, Freya, Boustred, Christopher R., Brittain, Helen, Caulfield, Mark J., Chan, Georgia C., Elgar, Greg, Fowler, Tom, Giess, Adam, Hamblin, Angela, Henderson, Shirley, Hubbard, Tim J.P., Jackson, Rob, Jones, Louise J., Kasperaviciute, Dalia, Kayikci, Melis, Kousathanas, Athanasios, Lahnstein, Lea, Leigh, Sarah E.A., Leong, Ivonne U.S., Lopez, Javier F., Maleady-Crowe, Fiona, McEntagart, Meriel, Minneci, Federico, Moutsianas, Loukas, Mueller, Michael, Murugaesu, Nirupa, Need, Anna C., O’Donovan, Peter, Odhams, Chris A., Patch, Christine, Pereira, Mariana Buongermino, Perez-Gil, Daniel, Pullinger, John, Rahim, Tahrima, Rendon, Augusto, Rogers, Tim, Savage, Kevin, Sawant, Kushmita, Scott, Richard H., Siddiq, Afshan, Sieghart, Alexander, Smith, Samuel C., Sosinsky, Alona, Stuckey, Alexander, Tanguy, Mélanie, Taylor Tavares, Ana Lisa, Thomas, Ellen R.A., Thompson, Simon R., Tucci, Arianna, Welland, Matthew J., Williams, Eleanor, Witkowska, Katarzyna, Wood, Suzanne M., Atan, Denize, Sayer, John A.

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Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease, Stroke Subtypes and Type 2 Diabetes: A Mendelian Randomization Analysis by Dale, Caroline E., Fatemifar, Ghazaleh, Palmer, Tom M., White, Jon, Prieto-Merino, David, Zabaneh, Delilah, Engmann, Jorgen E. L., Shah, Tina, Wong, Andrew, Warren, Helen R., McLachlan, Stela, Trompet, Stella, Moldovan, Max, Morris, Richard W., Sofat, Reecha, Kumari, Meena, Hyppönen, Elina, Jefferis, Barbara J., Gaunt, Tom R., Ben-Shlomo, Yoav, Zhou, Ang, Gentry-Maharaj, Aleksandra, Ryan, Andy, de Mutsert, Renée, Noordam, Raymond, Caulfield, Mark J., Jukema, Wouter, Worrall, Bradford B., Munroe, Patricia B., Menon, Usha, Power, Chris, Kuh, Diana, Lawlor, Debbie A., Humphries, Steve E., Mook-Kanamori, Dennis O., Davey Smith, George, Sattar, Naveed, Kivimaki, Mika, Price, Jacqueline F., Dudbridge, Frank, Hingorani, Aroon D., Holmes, Michael V., Casas, Juan P

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Testing the role of predicted gene knockouts in human anthropometric trait variation by Lessard, Samuel, Manning, Alisa K, Low-Kam, Cécile, Auer, Paul L, Giri, Ayush, Graff, Mariaelisa, Schurmann, Claudia, Yaghootkar, Hanieh, Luan, Jian'an, Esko, Tonu, Karaderi, Tugce, Bottinger, Erwin P, Lu, Yingchang, Carlson, Chris, Caulfield, Mark, Dubé, Marie-Pierre, Jackson, Rebecca D, Kooperberg, Charles, McKnight, Barbara, Mongrain, Ian, Peters, Ulrike, Reiner, Alex P, Rhainds, David, Sotoodehnia, Nona, Hirschhorn, Joel N, Scott, Robert A, Munroe, Patricia B, Frayling, Timothy M, Loos, Ruth J F, North, Kari E, Edwards, Todd L, Tardif, Jean-Claude, Lindgren, Cecilia M, Lettre, Guillaume

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