Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock by Sanchez-Pinto, L. Nelson, Bennett, Tellen D, DeWitt, Peter E, Russell, Seth, Rebull, Margaret N, Martin, Blake, Akech, Samuel, Albers, David J, Alpern, Elizabeth R, Balamuth, Fran, Bembea, Melania, Chisti, Mohammod Jobayer, Evans, Idris, Horvat, Christopher M, Jaramillo-Bustamante, Juan Camilo, Kissoon, Niranjan, Menon, Kusum, Scott, Halden F, Weiss, Scott L, Wiens, Matthew O, Zimmerman, Jerry J, Argent, Andrew C, Sorce, Lauren R, Schlapbach, Luregn J, Watson, R. Scott, Biban, Paolo, Carrol, Enitan, Chiotos, Kathleen, Flauzino De Oliveira, Claudio, Hall, Mark W, Inwald, David, Ishimine, Paul, Levin, Michael, Lodha, Rakesh, Nadel, Simon, Nakagawa, Satoshi, Peters, Mark J, Randolph, Adrienne G, Ranjit, Suchitra, Souza, Daniela Carla, Tissieres, Pierre, Wynn, James L

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Correction: Medicines and Healthcare products Regulatory Agency’s “Consultation on proposals for legislative changes for clinical trials”: a response from the Trials Methodology Re... by Law, Martin, Couturier, Dominique-Laurent, Choodari-Oskooei, Babak, Crout, Phillip, Gamble, Carrol, Jacko, Peter, Pallmann, Philip, Pilling, Mark, Robertson, David S., Robling, Michael, Sydes, Matthew R., Villar, Sofía S., Wason, James, Wheeler, Graham, Williamson, S. Faye, Yap, Christina, Jaki, Thomas

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Quantifying the carbon footprint of clinical trials: guidance development and case studies by Griffiths, Jessica, Fox, Lisa, Williamson, Paula R, Adshead, Fiona, Salman, Rustam Al-Shahi, Anderson, Craig, Bedson, Emma, Bliss, Judith, Boshoff, Ana, Chen, Xiaoying, Cranley, Denise, Doran, Peter, Gamble, Carrol, Hood, Kerenza, McGregor, Naomi, McNamara, Carolyn, Midha, Elis, Moore, Keith, Perkins, Alexis M, Pett, Sarah, Sydes, Matthew R

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Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19 by Thwaites, Ryan S, Sanchez Sevilla Uruchurtu, Ashley, Siggins, Matthew K, Liew, Felicity, Russell, Clark D, Moore, Shona C, Fairfield, Cameron, Carter, Edwin, Abrams, Simon, Short, Charlotte-Eve, Thaventhiran, Thilipan, Bergstrom, Emma, Gardener, Zoe, Ascough, Stephanie, Chiu, Christopher, Docherty, Annemarie B, Hunt, David, Crow, Yanick J, Solomon, Tom, Taylor, Graham P, Turtle, Lance, Harrison, Ewen M, Dunning, Jake, Semple, Malcolm G, Baillie, J Kenneth, Openshaw, Peter Jm

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Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multicentre, single-blinded, randomised trial and economic evaluation by Mallucci, Conor L, Jenkinson, Michael D, Conroy, Elizabeth J, Hartley, John C, Brown, Michaela, Dalton, Joanne, Kearns, Tom, Moitt, Tracy, Griffiths, Michael J, Culeddu, Giovanna, Solomon, Tom, Hughes, Dyfrig, Gamble, Carrol, Pettorini, Benedetta, Parks, Christopher, van Tonder, Libby, Foster, Mitchel T, McMahon, Catherine, Buxton, Neil, Chavredakis, Emmanuel, Brodbelt, Andrew R, Lawson, David DA, Eldridge, Paul R, Farah, Jibril O, Zakaria, Rasheed, Geraint, Sunderland, Solanki, Guirish, Rodrigues, Desiderio, Edwards, Richard, Williams, Adam, Garnett, Matthew, Kolias, Angelos, Hutchinson, Peter JA, Caldwell, Karen, Tarantino, Silvia, Leach, Paul, Zaben, Malik, Zilani, Gulam, Shastin, Dmitri, Merola, Joseph, Hussain, Rahim, Vemaraju, Ravindra, Selezneva, Liudmila, Radford, Georgina, Lloyd, Nadine, Crimmins, Darach, Caird, John, Sayar, Maria N, Thompson, Dominic, Aquilina, Kristian, James, Gregory, Strachan, Roger, Mukerji, Nitin, Thakur, Bhaskar, Dickson, Holly, Nsirim, Eniola, Goodden, John, Deniz, Kenan, Clarke, Janet, Kambafwile, Mary, Anderson, Ian, Chave-Cox, Rebecca, Sheik, Asim, Mathew, Ryan, Richards, Oliver, Mukherjee, Soumya, Chumas, Paul, Tyagi, Atul, Sikakumar, Gnanamurthy, Toma, Admed, D'Antona, Linda, Watkins, Laurence, Thorne, Lewis, Bassen, Vanessa, Holliman, Damien, Coulter, Ian, Macarthur, Donald, Howarth, Simon, Smith, Stuart, Javed, Shazia, Kamaly, Ian, Ramirez, Roberto, King, Andrew, Nadig, Ardash, Thorne, John, Ushewokunze, Shungu, Sinha, Saurabh, Zaki, Hesham, McMullan, John, Bulters, Diederik, Waters, Ryan, Zilidis, George, Roach, Joy, Sadek, Ahmed, Holton, Patrick, Zolnourian, Ardalan, Chakraborty, Aabir, Kandasamy, Jothy, Hughes, Mark, Brennan, Paul M

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PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO): protocol for a multicentre, open-label,... by Euden, Joanne, Thomas-Jones, Emma, Aston, Stephen, Brookes-Howell, Lucy, Carman, Julie, Carrol, Enitan, Gilbert, Stephanie, Howard, Philip, Hood, Kerenza, Inada-Kim, Matthew, Llewelyn, Martin, McGill, Fiona, Milosevic, Sarah, Niessen, Louis Wihelmus, Nsutebu, Emmanuel, Pallmann, Philip, Schmidt, Paul, Taylor-Robinson, David, Welters, Ingeborg, Todd, Stacy, French, Neil, Clarkstone, Sam, Hughes, Jacqui, Meister, Lena, Tabner, Andrew, Barlow, Gavin, Body, Richard, Bradburn, Mike, Daniels, Jane, Richards, Emma, Brain, Angela, Walker, Sarah, Goodacre, Steve, Scarborough, Matthew, O'Shea, Sian, James, Claire

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Delivery, setting and outcomes of paediatric Outpatient Parenteral Antimicrobial Therapy (OPAT): a scoping review by Carter, Bernie, Carrol, Enitan D, Porter, David, Peak, Matthew, Taylor-Robinson, David, Fisher-Smith, Debra, Blake, Lucy

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What is the carbon footprint of academic clinical trials? A study of hotspots in 10 trials by Griffiths, Jessica, Adshead, Fiona, Al-Shahi Salman, Rustam, Anderson, Craig, Bedson, Emma, Bliss, Judith, Boshoff, Ana, Chen, Xiaoying, Cranley, Denise, Doran, Peter, Dunne, Fidelma, Gamble, Carrol, Gillies, Katie, Hood, Kerenza, Kavanagh, Columb, Malone, Julia, McGregor, Naomi, McNamara, Carolyn, Midha, Elis, Moore, Keith, Murphy, Lucy, Newman, Christine, O'Reilly, Seamus, Perkins, Alexis M, Pett, Sarah, Sydes, Matthew Robert, Whitty, Laura, You, Frank, Fox, Lisa, Williamson, Paula R

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Paediatric Outpatient Parenteral Antimicrobial Therapy by Carter, Bernie, Fisher-Smith, Debra, Porter, David, Lane, Steven, Peak, Matthew, Taylor-Robinson, David, Bracken, Louise, Carrol, Enitan D

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Parents’ experiences and perceptions of the acceptability of a whole-hospital, pro-active electronic pediatric early warning system (the DETECT study): A qualitative interview stud... by Saron, Holly, Carter, Bernie, Siner, Sarah, Preston, Jennifer, Peak, Matthew, Mehta, Fulya, Lane, Steven, Lambert, Caroline, Jones, Dawn, Hughes, Hannah, Harris, Jane, Evans, Leah, Dee, Sarah, Eyton-Chong, Chin-Kien, Carrol, Enitan D., Sefton, Gerri

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Early phase clinical trials extension to guidelines for the content of statistical analysis plans by Homer, Victoria, Yap, Christina, Bond, Simon, Holmes, Jane, Stocken, Deborah, Walker, Katrina, Robinson, Emily J, Wheeler, Graham, Brown, Sarah, Hinsley, Samantha, Schipper, Matthew, Weir, Christopher J, Rantell, Khadija, Prior, Thomas, Yu, Ly-Mee, Kirkpatrick, John, Bedding, Alun, Gamble, Carrol, Gaunt, Piers

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A third trial oversight committee: Functions, benefits and issues by Lane, J Athene, Gamble, Carrol, Cragg, William J, Tembo, Doreen, Sydes, Matthew R

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Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer by Webster, Andrew L. H., Sanders, Mathijs A., Patel, Krupa, Dietrich, Ralf, Noonan, Raymond J., Lach, Francis P., White, Ryan R., Goldfarb, Audrey, Hadi, Kevin, Edwards, Matthew M., Donovan, Frank X., Hoogenboezem, Remco M., Jung, Moonjung, Sridhar, Sunandini, Wiley, Tom F., Fedrigo, Olivier, Tian, Huasong, Rosiene, Joel, Heineman, Thomas, Kennedy, Jennifer A., Bean, Lorenzo, Rosti, Rasim O., Tryon, Rebecca, Gonzalez, Ashlyn-Maree, Rosenberg, Allana, Luo, Ji-Dung, Carroll, Thomas S., Shroff, Sanjana, Beaumont, Michael, Velleuer, Eunike, Rastatter, Jeff C., Wells, Susanne I., Surrallés, Jordi, Bagby, Grover, MacMillan, Margaret L., Wagner, John E., Cancio, Maria, Boulad, Farid, Scognamiglio, Theresa, Vaughan, Roger, Beaumont, Kristin G., Koren, Amnon, Imielinski, Marcin, Chandrasekharappa, Settara C., Auerbach, Arleen D., Singh, Bhuvanesh, Kutler, David I., Campbell, Peter J., Smogorzewska, Agata

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Medical records-based chronic kidney disease phenotype for clinical care and “big data” observational and genetic studies by Shang, Ning, Khan, Atlas, Polubriaginof, Fernanda, Zanoni, Francesca, Mehl, Karla, Fasel, David, Drawz, Paul E., Carrol, Robert J., Denny, Joshua C., Hathcock, Matthew A., Arruda-Olson, Adelaide M., Peissig, Peggy L., Dart, Richard A., Brilliant, Murray H., Larson, Eric B., Carrell, David S., Pendergrass, Sarah, Verma, Shefali Setia, Ritchie, Marylyn D., Benoit, Barbara, Gainer, Vivian S., Karlson, Elizabeth W., Gordon, Adam S., Jarvik, Gail P., Stanaway, Ian B., Crosslin, David R., Mohan, Sumit, Ionita-Laza, Iuliana, Tatonetti, Nicholas P., Gharavi, Ali G., Hripcsak, George, Weng, Chunhua, Kiryluk, Krzysztof

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Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19 by Sidhu, Jasmin K, Siggins, Matthew K, Liew, Felicity, Russell, Clark D, Uruchurtu, Ashley S S, Davis, Christopher, Turtle, Lance, Moore, Shona C, Hardwick, Hayley E, Oosthuyzen, Wilna, Thomson, Emma C, Semple, Malcolm G, Baillie, J Kenneth, Openshaw, Peter J M, Thwaites, Ryan S

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Clinical utility and acceptability of a whole-hospital, pro-active electronic paediatric early warning system by Carter, Bernie, Saron, Holly, Blake, Lucy, Eyton-Chong, Chin-Kien, Dee, Sarah, Evans, Leah, Harris, Jane, Hughes, Hannah, Jones, Dawn, Lambert, Caroline, Lane, Steven, Mehta, Fulya, Peak, Matthew, Preston, Jennifer, Siner, Sarah, Sefton, Gerri, Carrol, Enitan D

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Norepinephrine induces growth of Desulfovibrio vulgaris in an iron dependent manner by Coffman, Cristina N., Varga, Matthew G., Alcock, Joe, Carrol-Portillo, Amanda, Singh, Sudha B., Xue, Xiang, Lin, Henry C.

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The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection by Goldswain, Hannah, Dong, Xiaofeng, Penrice-Randal, Rebekah, Alruwaili, Muhannad, Shawli, Ghada T, Prince, Tessa, Williamson, Maia Kavanagh, Raghwani, Jayna, Randle, Nadine, Jones, Benjamin, Donovan-Banfield, I'ah, Salguero, Francisco J, Tree, Julia A, Hall, Yper, Hartley, Catherine, Erdmann, Maximilian, Bazire, James, Jearanaiwitayakul, Tuksin, Semple, Malcolm G, Openshaw, Peter J M, Baillie, J Kenneth, Emmett, Stevan R, Digard, Paul, Matthews, David A, Turtle, Lance, Darby, Alistair C, Davidson, Andrew D, Carroll, Miles W, Hiscox, Julian A

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Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses by Michael, Benedict D., Dunai, Cordelia, Needham, Edward J., Tharmaratnam, Kukatharmini, Williams, Robyn, Huang, Yun, Boardman, Sarah A., Clark, Jordan J., Sharma, Parul, Subramaniam, Krishanthi, Wood, Greta K., Collie, Ceryce, Digby, Richard, Ren, Alexander, Norton, Emma, Leibowitz, Maya, Ebrahimi, Soraya, Fower, Andrew, Fox, Hannah, Tato, Esteban, Ellul, Mark A., Sunderland, Geraint, Held, Marie, Hetherington, Claire, Egbe, Franklyn N., Palmos, Alish, Stirrups, Kathy, Grundmann, Alexander, Chiollaz, Anne-Cecile, Sanchez, Jean-Charles, Stewart, James P., Griffiths, Michael, Solomon, Tom, Breen, Gerome, Coles, Alasdair J., Kingston, Nathalie, Bradley, John R., Chinnery, Patrick F., Cavanagh, Jonathan, Irani, Sarosh R., Vincent, Angela, Baillie, J. Kenneth, Openshaw, Peter J., Semple, Malcolm G., Taams, Leonie S., Menon, David K.

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Qualitative data sharing practices in clinical trials in the UK and Ireland: towards the production of good practice guidance by McCarthy, Megan, Gillies, Katie, Rousseau, Nikki, Wade, Julia, Gamble, Carrol, Toomey, Elaine, Matvienko-Sikar, Karen, Sydes, Matthew, Dowling, Maura, Bryant, Val, Biesty, Linda, Houghton, Catherine

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