Purification of recombinant adeno-associated virus type 8 vectors by ion exchange chromatography generates clinical grade vector stock by Davidoff, Andrew M., Ng, Catherine Y.C., Sleep, Susan, Gray, John, Azam, Selina, Zhao, Yuan, McIntosh, Jenny H., Karimipoor, Morteza, Nathwani, Amit C.

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AAV-Mediated Expression of a Single-Chain FVIII Mimetic Antibody Efficiently Corrects Bleeding in Haemophilia a Mice by Muczynski, Vincent, Bun, Eric, Tanner, Lewis, McIntosh, Jenny H., Christophe, Olivier D., Nathwani, Amit C.

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Long-Term Persistence of Antibodies to Adeno-Associated Viral Vectors Following Gene Therapy with scAAV8-LP1-Fixco by McIntosh, Jenny H., Mohamed, Saira, Ireland, Lydia, Morton, Christopher L, Reiss, Ulrike M., Chowdary, Pratima, Tuddenham, Edward G. D., Davidoff, Andrew M., Nathwani, Amit C.

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Stable Therapeutic Transgenic FIX Levels for More Than 10 Years in Subjects with Severe Hemophilia B Who Received scAAV2/8-LP1-Hfixco Adeno-Associated Virus Gene Therapy by Reiss, Ulrike M., Davidoff, Andrew M., Tuddenham, Edward G. D., Chowdary, Pratima, McIntosh, Jenny H., Riddell, Anne, Pie, Arnulfo, Batty, Paul, Calvert, Joanna C. M., Mangles, Sarah, Mahlangu, Johnny, Haley, Kristina M., Recht, Michael, Shen, Yu-Min, Halka, Kathleen G., Zhou, Junfang, Kang, Guolian, Okhomina, Victoria, Morton, Christopher L, Nathwani, Amit C.

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GO-8: Stable Expression of Factor VIII over 5 Years Following Adeno-Associated Gene Transfer in Subjects with Hemophilia a Using a Novel Human Factor VIII Variant by Chowdary, Pratima, Reiss, Ulrike M., Tuddenham, Edward G. D., Batty, Paul, McIntosh, Jenny H., Radulescu, Vlad Calin, Chang, Eugenia, Laffan, Michael A., Riddell, Anne, Calvert, Joanna C. M., Pie, Arnulfo, Peralta, Rita, Dissanayake, Upuli Pabakumari, Kamel, Kirollos, Sreedhar, Bharath Ram, Zhou, Junfang, Kang, Guolian, Olufadi, Yunus, Meagher, Michael M, Morton, Christopher L, Evans, Alison J., Davidoff, Andrew M., Nathwani, Amit C.

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Assessing the Potential of Perinatal Gene Transfer Using Congenital Factor VII Deficiency as a Model System by Binny, Christopher J, McIntosh, Jenny H, Tuddenham, Edward, Waddington, Simon, Buckley, Suzanne, Thrasher, Adrian, Gray, John T., Nathwani, Amit, Tarantal, Alice F, Davidoff, Andrew

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Adeno-Associated Viral Vector Mediated Gene Transfer for Hemophilia B by Nathwani, Amit C, Tuddenham, Edward GD, Rangarajan, Savita, Rosales, Cecilia, McIntosh, Jenny H, Linch, David C, Chowdary, Pratima, Griffioen, Anja, Riddell, Anne, Pie, Jun, Harrington, Chris, O'Beirne, James, Smith, Keith, Pasi, John, Glader, Bertil, Rustagi, Pradip, Ng, Catherine, Kay, Mark, Zhou, Junfang, Spence, Yunyu, Morton, Christopher, Allay, James, Coleman, John, Sleep, Susan, Cunningham, John M, Basner-Tschakarjan, Etiena, Mingozzi, Federico, High, Katherine A., Gray, John T., Reiss, Ulrike M., Nienhuis, Arthur W., Davidoff, Andrew

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Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant by McIntosh, Jenny, Lenting, Peter J., Rosales, Cecilia, Lee, Doyoung, Rabbanian, Samira, Raj, Deepak, Patel, Nishil, Tuddenham, Edward G.D., Christophe, Olivier D., McVey, John H., Waddington, Simon, Nienhuis, Arthur W., Gray, John T., Fagone, Paolo, Mingozzi, Federico, Zhou, Shang-Zhen, High, Katherine A., Cancio, Maria, Ng, Catherine Y.C., Zhou, Junfang, Morton, Christopher L., Davidoff, Andrew M., Nathwani, Amit C.

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Codon optimization of human factor VIII cDNAs leads to high-level expression by Ward, Natalie J., Buckley, Suzanne M.K., Waddington, Simon N., VandenDriessche, Thierry, Chuah, Marinee K.L., Nathwani, Amit C., McIntosh, Jenny, Tuddenham, Edward G.D., Kinnon, Christine, Thrasher, Adrian J., McVey, John H.

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Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging by McCartney, Daniel L, Min, Josine L, Richmond, Rebecca C, Lu, Ake T, Sobczyk, Maria K, Davies, Gail, Broer, Linda, Guo, Xiuqing, Jeong, Ayoung, Jung, Jeesun, Kasela, Silva, Katrinli, Seyma, Kuo, Pei-Lun, Matias-Garcia, Pamela R, Mishra, Pashupati P, Nygaard, Marianne, Palviainen, Teemu, Patki, Amit, Raffield, Laura M, Ratliff, Scott M, Richardson, Tom G, Robinson, Oliver, Soerensen, Mette, Sun, Dianjianyi, Tsai, Pei-Chien, van der Zee, Matthijs D, Walker, Rosie M, Wang, Xiaochuan, Wang, Yunzhang, Xia, Rui, Xu, Zongli, Yao, Jie, Zhao, Wei, Correa, Adolfo, Boerwinkle, Eric, Dugué, Pierre-Antoine, Durda, Peter, Elliott, Hannah R, Gieger, Christian, de Geus, Eco J C, Harris, Sarah E, Hemani, Gibran, Imboden, Medea, Kähönen, Mika, Kardia, Sharon L R, Kresovich, Jacob K, Li, Shengxu, Lunetta, Kathryn L, Mangino, Massimo, Mason, Dan, McIntosh, Andrew M, Mengel-From, Jonas, Moore, Ann Zenobia, Murabito, Joanne M, Ollikainen, Miina, Pankow, James S, Pedersen, Nancy L, Peters, Annette, Polidoro, Silvia, Porteous, David J, Raitakari, Olli, Rich, Stephen S, Sandler, Dale P, Sillanpää, Elina, Smith, Alicia K, Southey, Melissa C, Strauch, Konstantin, Tiwari, Hemant, Tanaka, Toshiko, Tillin, Therese, Uitterlinden, Andre G, Van Den Berg, David J, van Dongen, Jenny, Wilson, James G, Wright, John, Yet, Idil, Arnett, Donna, Bandinelli, Stefania, Bell, Jordana T, Binder, Alexandra M, Boomsma, Dorret I, Chen, Wei, Christensen, Kaare, Conneely, Karen N, Elliott, Paul, Ferrucci, Luigi, Fornage, Myriam, Hägg, Sara, Hayward, Caroline, Irvin, Marguerite, Kaprio, Jaakko, Lawlor, Deborah A, Lehtimäki, Terho, Lohoff, Falk W, Milani, Lili, Milne, Roger L, Probst-Hensch, Nicole, Reiner, Alex P, Ritz, Beate, Rotter, Jerome I

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DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan by van Dongen, Jenny, Hagenbeek, Fiona A., Suderman, Matthew, Roetman, Peter J., Sugden, Karen, Chiocchetti, Andreas G., Ismail, Khadeeja, Mulder, Rosa H., Hafferty, Jonathan D., Adams, Mark J., Walker, Rosie M., Morris, Stewart W., Lahti, Jari, Küpers, Leanne K., Escaramis, Georgia, Alemany, Silvia, Jan Bonder, Marc, Meijer, Mandy, Ip, Hill F., Jansen, Rick, Baselmans, Bart M. L., Parmar, Priyanka, Lowry, Estelle, Streit, Fabian, Sirignano, Lea, Send, Tabea S., Frank, Josef, Jylhävä, Juulia, Wang, Yunzhang, Mishra, Pashupati Prasad, Colins, Olivier F., Corcoran, David L., Poulton, Richie, Mill, Jonathan, Hannon, Eilis, Arseneault, Louise, Korhonen, Tellervo, Vuoksimaa, Eero, Felix, Janine F., Bakermans-Kranenburg, Marian J., Campbell, Archie, Czamara, Darina, Binder, Elisabeth, Corpeleijn, Eva, Gonzalez, Juan R., Grazuleviciene, Regina, Gutzkow, Kristine B., Evandt, Jorunn, Vafeiadi, Marina, Klein, Marieke, van der Meer, Dennis, Ligthart, Lannie, Kluft, Cornelis, Davies, Gareth E., Hakulinen, Christian, Keltikangas-Järvinen, Liisa, Franke, Barbara, Freitag, Christine M., Konrad, Kerstin, Hervas, Amaia, Fernández-Rivas, Aranzazu, Vetro, Agnes, Raitakari, Olli, Lehtimäki, Terho, Vermeiren, Robert, Strandberg, Timo, Räikkönen, Katri, Snieder, Harold, Witt, Stephanie H., Deuschle, Michael, Pedersen, Nancy L., Hägg, Sara, Sunyer, Jordi, Franke, Lude, Kaprio, Jaakko, Ollikainen, Miina, Moffitt, Terrie E., Tiemeier, Henning, van IJzendoorn, Marinus H., Relton, Caroline, Vrijheid, Martine, Sebert, Sylvain, Jarvelin, Marjo-Riitta, Caspi, Avshalom, Evans, Kathryn L., McIntosh, Andrew M., Bartels, Meike, Boomsma, Dorret I.

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Digital pathology for reporting histopathology samples, including cancer screening samples – definitive evidence from a multisite study by Azam, Ayesha S, Tsang, Yee‐Wah, Thirlwall, Jenny, Kimani, Peter K, Sah, Shatrughan, Gopalakrishnan, Kishore, Boyd, Clinton, Loughrey, Maurice B, Kelly, Paul J, Boyle, David P, Salto‐Tellez, Manuel, Clark, David, Ellis, Ian O, Ilyas, Mohammad, Rakha, Emad, Bickers, Adam, Roberts, Ian S D, Soares, Maria F, Neil, Desley A H, Takyi, Abi, Raveendran, Sinthuri, Hero, Emily, Evans, Harriet, Osman, Rania, Fatima, Khunsha, Hughes, Rhian W, McIntosh, Stuart A, Moran, Gordon W, Ortiz‐Fernandez‐Sordo, Jacobo, Rajpoot, Nasir M, Storey, Ben, Ahmed, Imtiaz, Dunn, Janet A, Hiller, Louise, Snead, David R J

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Distinct alterations in probabilistic reversal learning across at-risk mental state, first episode psychosis and persistent schizophrenia by Griffin, J. D., Diederen, K. M. J., Haarsma, J., Jarratt Barnham, I. C., Cook, B. R. H., Fernandez-Egea, E., Williamson, S., van Sprang, E. D., Gaillard, R., Vinckier, F., Goodyer, I. M., Murray, G. K., Fletcher, P. C.

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A Novel Lysine to Arginine Substitution at Position 301 Enhances Activity of Factor IX by Verhoef, Daniel, Foley, Jonathan H., Goodale, Andrew, Macrae, Emma, McIntosh, Jenny, Corbau, Romuald, Gomez, Keith, Riddell, Anne, Nathwani, Amit C

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The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19) by Shi, Jianguo, McIntosh, Richard S, Adame-Gallegos, Jaime, Dehal, Prabhjyot K, van Egmond, Marjolein, van de Winkel, Jan, Draper, Simon J, Forbes, Emily K, Corran, Patrick H, Holder, Anthony A, Woof, Jenny M, Pleass, Richard J

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Liver-Directed AAV Gene Therapy for Gaucher Disease by Miranda, Carlos J, Canavese, Miriam, Chisari, Elisa, Pandya, Jalpa, Cocita, Clement, Portillo, Maria, McIntosh, Jenny, Kia, Azadeh, Foley, Jonathan H., Dane, Allison, Jeyakumar, Jey M, Sheridan, Rose, Corbau, Romuald, Nathwani, Amit C.

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Design and Characterization of FLT210, a Potent Next Generation AAV-hFVIII Vector Candidate by Kia, Azadeh, Comper, Fabrizio, Correia, Samantha, Casari, Caterina, Negash, Segen, Portillo, Maria, Pandya, Jalpa, Dodev, Tihomir, Schulze, Andreas, Sonntag, Florian, Kober, Renee, Cocita, Clement, Chisari, Elisa, Alade, Rebecca, Shehu, Erald, Jeyakumar, Jey M, Khinder, Jaminder, Foley, Jonathan H., Dane, Allison, McIntosh, Jenny, Ollerton, Hattie, Christophe, Olivier, Denis, Cecile V., Corbau, Romuald

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AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage by Binny, Christopher, McIntosh, Jenny, Della Peruta, Marco, Kymalainen, Hanna, Tuddenham, Edward G.D., Buckley, Suzanne M.K., Waddington, Simon N., McVey, John H., Spence, Yunyu, Morton, Christopher L., Thrasher, Adrian J., Gray, John T., Castellino, Francis J., Tarantal, Alice F., Davidoff, Andrew M., Nathwani, Amit C.

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The spectrum of PIG-A gene mutations in aplastic anemia/paroxysmal nocturnal hemoglobinuria (AA/PNH): a high incidence of multiple mutations and evidence of a mutational hot spot by MORTAZAVI, Yousef, MERK, Bruno, MCINTOSH, Jenny, MARSH, Judith C. W, SCHREZENMEIER, Hubert, RUTHERFORD, Tim R

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Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV... by Tan, Mei Hong, Smith, Alexander J., Pawlyk, Basil, Xu, Xiaoyun, Liu, Xiaoqing, Bainbridge, James B., Basche, Mark, McIntosh, Jenny, Tran, Hoai Viet, Nathwani, Amit, Li, Tiansen, Ali, Robin R.

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