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Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer
by
Zbieg, Jason R.
,
Liang, Jun
,
Li, Jun
,
Blake, Robert A.
,
Chang, Jae
,
Friedman, Lori
,
Goodacre, Simon
,
Hartman, Steven J.
,
Rei Ingalla, Ellen
,
Kiefer, James R.
,
Kleinheinz, Tracy
,
Labadie, Sharada
,
Lai, Tommy
,
Liao, Jiangpeng
,
McLean, Nev
,
Metcalfe, Ciara
,
Mody, Vidhi
,
Nannini, Michelle
,
Ortwine, Daniel F.
,
Ran, Yingqing
,
Ray, Nick
,
Roussel, Fabien
,
Sambrone, Amy
,
Sampath, Deepak
,
Vinogradova, Maia
,
Wai, John
,
Wang, Tao
,
Yeap, Kuen
,
Zhang, Birong
,
Zheng, Xiaoping
,
Zhong, Yu
,
Wang, Xiaojing
Published in
Bioorganic & medicinal chemistry letters
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Journal Title
Bioorganic & Medicinal Chemistry Letters
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Subjects
Animals
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Antineoplastic Agents - Administration & Dosage
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Antineoplastic Agents - Chemistry
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Antineoplastic Agents - Pharmacokinetics
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Antineoplastic Agents - Pharmacology
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Breast Neoplasms - Drug Therapy
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Chemistry
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Chemistry, Medicinal
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Chemistry, Organic
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Dose-Response Relationship, Drug
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Drug Discovery
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Estrogen Receptor
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Female
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Fulvestrant
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Gne-149
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Gne-502
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Humans
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Life Sciences & Biomedicine
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Mcf-7 Cells
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Mice
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Year of Publication
From:
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1400 : 2025
1400
2025
Source
Sciencedirect
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Sciencedirect Freedom Collection 2022-2024
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Sciencedirect: Organic Chemistry Backfile
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