Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models by Singh Mali, Raghuveer, Zhang, Qi, DeFilippis, Rosa Anna, Cavazos, Antonio, Kuruvilla, Vinitha Mary, Raman, Jayant, Mody, Vidhi, Choo, Edna F, Dail, Monique, Shah, Neil P, Konopleva, Marina, Sampath, Deepak, Lasater, Elisabeth A

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GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer by Liang, Jun, Zbieg, Jason R., Blake, Robert A., Chang, Jae H., Daly, Stephen, DiPasquale, Antonio G., Friedman, Lori S., Gelzleichter, Thomas, Gill, Matthew, Giltnane, Jennifer M., Goodacre, Simon, Guan, Jane, Hartman, Steven J., Ingalla, Ellen Rei, Kategaya, Lorn, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada S., Lai, Tommy, Li, Jun, Liao, Jiangpeng, Liu, Zhiguo, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle A., Oeh, Jason, O’Rourke, Martin G., Ortwine, Daniel F., Ran, Yingqing, Ray, Nicholas C., Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Schutt, Leah K., Vinogradova, Maia, Wai, John, Wang, Tao, Wertz, Ingrid E., White, Jonathan R., Yeap, Siew Kuen, Young, Amy, Zhang, Birong, Zheng, Xiaoping, Zhou, Wei, Zhong, Yu, Wang, Xiaojing

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Abstract 3406: GDC-9545: A pure antiestrogen clinical candidate that immobilizes the estrogen receptor and profoundly alters chromatin accessibility in vivo by Metcalfe, Ciara, Zhou, Wei, Guan, Jane, Blake, Robert A., De Bruyn, Tom, Giltnane, Jennifer M., Ingalla, Ellen, Kleinheinz, Tracy, Liang, Jun, Mody, Vidhi, Oeh, Jason, Ubhayakar, Savita, Wertz, Ingrid, Young, Amy, Zbieg, Jason, Wang, Xiaojing, Hafner, Marc

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Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer by Zbieg, Jason R., Liang, Jun, Li, Jun, Blake, Robert A., Chang, Jae, Friedman, Lori, Goodacre, Simon, Hartman, Steven J., Rei Ingalla, Ellen, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada, Lai, Tommy, Liao, Jiangpeng, McLean, Nev, Metcalfe, Ciara, Mody, Vidhi, Nannini, Michelle, Ortwine, Daniel F., Ran, Yingqing, Ray, Nick, Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Vinogradova, Maia, Wai, John, Wang, Tao, Yeap, Kuen, Zhang, Birong, Zheng, Xiaoping, Zhong, Yu, Wang, Xiaojing

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Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927 by Labadie, Sharada S., Li, Jun, Blake, Robert A., Chang, Jae H., Goodacre, Simon, Hartman, Steven J., Liang, Weiling, Kiefer, James R., Kleinheinz, Tracy, Lai, Tommy, Liao, Jiangpeng, Ortwine, Daniel F., Mody, Vidhi, Ray, Nicholas C., Roussel, Fabien, Vinogradova, Maia, Yeap, Siew Kuen, Zhang, Birong, Zheng, Xiaoping, Zbieg, Jason R., Liang, Jun, Wang, Xiaojing

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Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha by Zhang, Birong, Kiefer, James R., Blake, Robert A., Chang, Jae H., Hartman, Steven, Ingalla, Ellen Rei, Kleinheinz, Tracy, Mody, Vidhi, Nannini, Michelle, Ortwine, Daniel F., Ran, Yingqing, Sambrone, Amy, Sampath, Deepak, Vinogradova, Maia, Zhong, Yu, Nwachukwu, Jerome C., Nettles, Kendall W., Lai, Tommy, Liao, Jiangpeng, Zheng, Xiaoping, Chen, Hai, Wang, Xiaojing, Liang, Jun

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Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer by Liang, Jun, Blake, Robert, Chang, Jae, Friedman, Lori S, Goodacre, Simon, Hartman, Steven, Ingalla, Ellen Rei, Kiefer, James R, Kleinheinz, Tracy, Labadie, Sharada, Li, Jun, Lai, Kwong Wah, Liao, Jiangpeng, Mody, Vidhi, McLean, Neville, Metcalfe, Ciara, Nannini, Michelle, Otwine, Daniel, Ran, Yingqing, Ray, Nick, Roussel, Fabien, Sambrone, Amy, Sampath, Deepak, Vinogradova, Maia, Wai, John, Wang, Tao, Yeap, Kuen, Young, Amy, Zbieg, Jason, Zhang, Birong, Zheng, Xiaoping, Zhong, Yu, Wang, Xiaojing

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Physiologically Based Pharmacokinetic Model for Composite Nanodevices: Effect of Charge and Size on In Vivo Disposition by Mager, Donald E., Mody, Vidhi, Xu, Chao, Forrest, Alan, Lesniak, Wojciech G., Nigavekar, Shraddha S., Kariapper, Muhammed T., Minc, Leah, Khan, Mohamed K., Balogh, Lajos P.

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Abstract 1648: Discovery and evolution of orally bioavailable selective estrogen receptor degraders for ER+ breast cancer: From GDC-0810 to GDC-0927 by Kahraman, Mehmet, Govek, Steven P., Nagasawa, Johnny Y., Lai, Andiliy, Bonnefous, Celine, Douglas, Karensa, Sensintaffar, John, Lu, Nhin, Lee, KyoungJin, Aparicio, Anna, Kaufman, Josh, Qian, Jing, Shao, Gang, Prudente, Rene, Joseph, James D., Darimont, Beatrice, Brigham, Daniel, Heyman, Richard, Rix, Peter J., Hager, Jeffrey H., Smith, Nicholas D., Blake, Robert A., Chang, Jae, Choo, Edna, Daemen, Anneleen, Friedman, Lori S., Guan, Jane, Hartman, Steven, Ingalla, Ellen, Kiefer, James R., Kleinheinz, Tracy, Labadie, Sharada, Metcalfe, Ciara, Mody, Vidhi, Nannini, Michelle, Sampath, Deepak, Young, Amy, Vinogradova, Maia, Zhou, Wei, Liang, Jun, Wang, Xiaojing

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SYNFAC-EDIT: Synthetic Imitation Edit Feedback for Factual Alignment in Clinical Summarization by Mishra, Prakamya, Yao, Zonghai, Vashisht, Parth, Ouyang, Feiyun, Wang, Beining, Vidhi Dhaval Mody, Yu, Hong

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