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Targeted mutagenesis of the Vibrio fischeri flavin reductase FRase I to improve activation of the anticancer prodrug CB1954
by
Swe, P.M.
,
Copp, J.N.
,
Green, L.K.
,
Guise, C.P.
,
Mowday, A.M.
,
Smaill, J.B.
,
Patterson, A.V.
,
Ackerley, D.F.
Published in
Biochemical pharmacology
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Articles
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Biochemical Pharmacology
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Subjects
Aliivibrio Fischeri - Enzymology
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Antineoplastic Agents - Pharmacology
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Aziridines - Pharmacology
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Bacterial Proteins - Genetics
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Bacterial Proteins - Metabolism
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Cb1954
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Cell Line, Tumor
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Cell Proliferation - Drug Effects
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Directed Evolution
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Enzyme Prodrug Therapy
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Escherichia Coli
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Escherichia Coli - Genetics
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Fmn Reductase - Genetics
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Fmn Reductase - Metabolism
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Humans
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Kinetics
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Life Sciences & Biomedicine
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Models, Molecular
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Mutagenesis, Site-Directed
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Nitroreductase
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Sciencedirect Journals
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Sciencedirect Freedom Collection 2022-2024
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