Search Results - Niewola, Karolina

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  1. 1
    The highly selective and oral phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib induces apoptosis in mesothelioma cells and increases immune effector cell composition

    The highly selective and oral phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib induces apoptosis in mesothelioma cells and increases immune effector cell composition by Kalla, Claudia, Ott, German, Finotello, Francesca, Niewola-Staszkowska, Karolina, Conza, Giusy Di, Lahn, Michael, van der Veen, Lars, Schüler, Julia, Falkenstern-Ge, Roger, Kopecka, Joanna, Riganti, Chiara

    Published in Translational oncology
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  2. 2
    922 A novel autotaxin inhibitor, IOA-289, modulates tumor, immune and stromal cell function and has monotherapy activity in fibrotic cancer models

    922 A novel autotaxin inhibitor, IOA-289, modulates tumor, immune and stromal cell function and has monotherapy activity in fibrotic cancer models by Deken, Marcel, Niewola, Karolina, Matas-Rico, Elisa, Medhi, Ragini, Carruthers, Alan, Cheasty, Anne, Peyruchaud, Olivier, Fraser, Amy, Shah, Pritom, Moolenaar, Wouter, Veen, Lars van der, Lahn, Michael, Johnson, Zoe

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  3. 3
    WED-441 - A novel orally available type IV autotaxin inhibitor, IOA-289, ameliorates steatosis and fibrosis in a preclinical model of non-alcoholic steatohepatitis

    WED-441 - A novel orally available type IV autotaxin inhibitor, IOA-289, ameliorates steatosis and fibrosis in a preclinical model of non-alcoholic steatohepatitis by ten Hove, Marit, Di Conza, Giusy, Niewola, Karolina, Deken, Marcel, van der Veen, Lars, Bansal, Ruchi

    Published in Journal of hepatology
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  4. 4
    A novel orally available type IV autotaxin inhibitor, IOA-289, ameliorates steatosis and fibrosis in a preclinical model of non-alcoholic steatohepatitis

    A novel orally available type IV autotaxin inhibitor, IOA-289, ameliorates steatosis and fibrosis in a preclinical model of non-alcoholic steatohepatitis by ten Hove, Marit, Di Conza, Giusy, Niewola, Karolina, Deken, Marcel, van der Veen, Lars, Bansal, Ruchi

    Published in Journal of hepatology
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  5. 5
    A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast

    A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast by Kennedy, Michael A, Gable, Kenneth, Niewola-Staszkowska, Karolina, Abreu, Susana, Johnston, Anne, Harris, Linda J, Reggiori, Fulvio, Loewith, Robbie, Dunn, Teresa, Bennett, Steffany A L, Baetz, Kristin

    Published in PLoS genetics
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  6. 6
    Abstract 666: A novel, highly selective PI3Kδ inhibitor for the treatment of solid malignancies that express high levels of target protein as assessed by immunohistochemistry

    Abstract 666: A novel, highly selective PI3Kδ inhibitor for the treatment of solid malignancies that express high levels of target protein as assessed by immunohistochemistry by MacQueen, Amy R., Viticchie, Giuditta, Niewola, Karolina, Finotello, Francesca, Powley, Ian, Shah, Pritom, van der Veen, Lars, Lahn, Michael, Johnson, Zoe

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  7. 7
    Abstract 1877: IOA-237 - A potent anti-CD73 mAb demonstrates monotherapeutic and combination efficacy in solid tumor models

    Abstract 1877: IOA-237 - A potent anti-CD73 mAb demonstrates monotherapeutic and combination efficacy in solid tumor models by Deken, Marcel A., Carruthers, Alan M., Niewola-Staszkowska, Karolina, Gernon, Gráinne, Sandig, Hilary, Shah, Pritom, Lahn, Michael M., Johnson, Zoë

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  8. 8
    Abstract 2636: Targeting Autotaxin to suppress stromal signaling in the tumor microenvironment to improve outcome to therapy in fibrotic tumor types

    Abstract 2636: Targeting Autotaxin to suppress stromal signaling in the tumor microenvironment to improve outcome to therapy in fibrotic tumor types by Johnson, Zoe, Deken, Marcel, Medhi, Ragini, Maggs, Lauren, Carruthers, Alan, Cheasty, Anne, Tagliavini, Alessia, Nizzardo, Andrea, Pergher, Marco, Niewola, Karolina, Fraser, Amy, van der Veen, Lars, Shah, Pritom, ZIviani, Luigi, Milleri, Stefano, Lahn, Michael

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  9. 9
    Abstract B165: A pharmacologic screen identifies drugs to be combined with the non-ATP competitive PI3Kδ inhibitor roginolisib (IOA-244) for an improved anti-tumor activity in lymphoma models

    Abstract B165: A pharmacologic screen identifies drugs to be combined with the non-ATP competitive PI3Kδ inhibitor roginolisib (IOA-244) for an improved anti-tumor activity in lymp... by Tarantelli, Chiara, Civanelli, Elisa, Cannas, Eleonora, Spriano, Filippo, Mensah, Afua A., Cascione, Luciano, Arribas, Alberto J, Stathis, Anastasios, Niewola-Staszkowska, Karolina, Conza, Giusy Di, Lahn, Michael, Bertoni, Francesco

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  10. 10
    A Signaling Lipid Associated with Alzheimer’s Disease Promotes Mitochondrial Dysfunction

    A Signaling Lipid Associated with Alzheimer’s Disease Promotes Mitochondrial Dysfunction by Kennedy, Michael A., Moffat, Tia C., Gable, Kenneth, Ganesan, Suriakarthiga, Niewola-Staszkowska, Karolina, Johnston, Anne, Nislow, Corey, Giaever, Guri, Harris, Linda J., Loewith, Robbie, Zaremberg, Vanina, Harper, Mary-Ellen, Dunn, Teresa, Bennett, Steffany A. L., Baetz, Kristin

    Published in Scientific reports
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  11. 11
    IOA-244 is a Non-ATP-competitive, Highly Selective, Tolerable PI3K Delta Inhibitor That Targets Solid Tumors and Breaks Immune Tolerance

    IOA-244 is a Non-ATP-competitive, Highly Selective, Tolerable PI3K Delta Inhibitor That Targets Solid Tumors and Breaks Immune Tolerance by Johnson, Zoë, Tarantelli, Chiara, Civanelli, Elisa, Cascione, Luciano, Spriano, Filippo, Fraser, Amy, Shah, Pritom, Nomanbhoy, Tyzoon, Napoli, Sara, Rinaldi, Andrea, Niewola-Staszkowska, Karolina, Lahn, Michael, Perrin, Dominique, Wenes, Mathias, Migliorini, Denis, Bertoni, Francesco, van der Veen, Lars, Di Conza, Giusy

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  12. 12
    A Neurotoxic Glycerophosphocholine Impacts PtdIns-4, 5-Bisphosphate and TORC2 Signaling by Altering Ceramide Biosynthesis in Yeast: e1004010

    A Neurotoxic Glycerophosphocholine Impacts PtdIns-4, 5-Bisphosphate and TORC2 Signaling by Altering Ceramide Biosynthesis in Yeast: e1004010 by Kennedy, Michael A, Gable, Kenneth, Niewola-Staszkowska, Karolina, Abreu, Susana, Johnston, Anne, Harris, Linda J, Reggiori, Fulvio, Loewith, Robbie, Dunn, Teresa, Bennett, Steffany AL, Baetz, Kristin

    Published in PLoS genetics
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