Characterization of Novel Selective H1-Antihistamines for Clinical Evaluation in the Treatment of Insomnia by Moree, Wilna J, Li, Bin-Feng, Jovic, Florence, Coon, Timothy, Yu, Jinghua, Gross, Raymond S, Tucci, Fabio, Marinkovic, Dragan, Zamani-Kord, Said, Malany, Siobhan, Bradbury, Margaret J, Hernandez, Lisa M, O’Brien, Zhihong, Wen, Jianyun, Wang, Hua, Hoare, Samuel R. J, Petroski, Robert E, Sacaan, Aida, Madan, Ajay, Crowe, Paul D, Beaton, Graham

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A pharmacokinetic evaluation of five H1 antagonists after an oral and intravenous microdose to human subjects by Madan, Ajay, O'Brien, Zhihong, Wen, Jianyun, O'Brien, Chris, Farber, Robert H., Beaton, Graham, Crowe, Paul, Oosterhuis, Berend, Garner, R. Colin, Lappin, Graham, Bozigian, Haig P.

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Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A Adenosine Receptor Antagonists for the Treatment of Parkinson’s Disease by Zhang, Xiaohu, Tellew, John E, Luo, Zhiyong, Moorjani, Manisha, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Williams, John P, Saunders, John, Lechner, Sandra M, Markison, Stacy, Joswig, Tanya, Petroski, Robert, Piercey, Jaime, Kargo, William, Malany, Siobhan, Santos, Mark, Gross, Raymond S, Wen, Jenny, Jalali, Kayvon, O’Brien, Zhihong, Stotz, Carol E, Crespo, María I, Díaz, José-Luis, Slee, Deborah H

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Novel benzothiophene H1-antihistamines for the treatment of insomnia by MOREE, Wilna J, JOVIC, Florence, HERNANDEZ, Lisa M, O'BRIEN, Zhihong, JIANYUN WEN, HUA WANG, HOARE, Samuel R. J, PETROSKI, Robert E, SACAAN, Aida, MADAN, Ajay, CROWE, Paul D, BEATON, Graham, COON, Timothy, JINGHUA YU, LI, Bin-Feng, TUCCI, Fabio C, MARINKOVIC, Dragan, GROSS, Raymond S, MALANY, Siobhan, BRADBURY, Margaret J

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Abstract C101: Preclinical and clinical pharmacokinetics (PK) of NBF-006, a novel siRNA inhibitor of glutathione-s-transferase P (GSTP) encapsulated in a lipid nanoparticle (LNP),... by Hall, Michael, O'Brien, Zhihong, Zabludoff, Sonya

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Validation and application of a liquid chromatography–tandem mass spectrometric method for the simultaneous determination of testosterone and dihydrotestosterone in rat prostatic t... by O’Brien, Zhihong, Post, Noah, Brown, Michael, Madan, Ajay, Coon, Timothy, Luo, Rosa, Kohout, Trudy A.

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Characterization of Novel Selective H 1 -Antihistamines for Clinical Evaluation in the Treatment of Insomnia by Moree, Wilna J., Li, Bin-Feng, Jovic, Florence, Coon, Timothy, Yu, Jinghua, Gross, Raymond S., Tucci, Fabio, Marinkovic, Dragan, Zamani-Kord, Said, Malany, Siobhan, Bradbury, Margaret J., Hernandez, Lisa M., O’Brien, Zhihong, Wen, Jianyun, Wang, Hua, Hoare, Samuel R. J., Petroski, Robert E., Sacaan, Aida, Madan, Ajay, Crowe, Paul D., Beaton, Graham

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Abstract 5918: A novel glutathione S-transferase P (GSTP) siRNA (NDT-05-1040) for the treatment of KRAS-driven non-small cell lung cancer by Cina, Cima, Harborth, Jens, O'Brien, Zhihong, Beltran-Raygoza, Nish, Jin, Jung-kang, Xu, Jessica, Lee, Sang Jun, Tsang, Kwok, Yao, Jiping, Adami, Roger, Zabludoff, Sonya, Ying, Wenbin

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Abstract 5917: A novel lipid nanoparticle (NBF-006) encapsulating glutathione S-transferase P (GSTP) siRNA for the treatment of KRAS-driven non-small cell lung cancer by O'Brien, Zhihong, Wang, Li, Majeti, Bharat, Clamme, Jeanpierre, Baclig, Robiel, Chu, James, Fong, Steven, Harborth, Jens, Ibarra, Jose, Yin, Haiqing, Yu, Jing, Zhang, Clayton, Adami, Roger, Zabludoff, Sonya, Ying, Wenbin

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N -[6-Amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A 2A Receptor Antagonists with Improved Drug Like Properties and in Vivo Efficacy by Lanier, Marion C., Moorjani, Manisha, Luo, Zhiyong, Chen, Yongsheng, Lin, Emily, Tellew, John E., Zhang, Xiaohu, Williams, John P., Gross, Raymond S., Lechner, Sandra M., Markison, Stacy, Joswig, Tanya, Kargo, William, Piercey, Jaime, Santos, Mark, Malany, Siobhan, Zhao, Marilyn, Petroski, Robert, Crespo, María I., Díaz, José-Luis, Saunders, John, Wen, Jenny, O’Brien, Zhihong, Jalali, Kayvon, Madan, Ajay, Slee, Deborah H.

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Identification of Novel, Water-Soluble, 2-Amino-N-pyrimidin-4-yl Acetamides as A2A Receptor Antagonists with In Vivo Efficacy by Slee, Deborah H, Zhang, Xiaohu, Moorjani, Manisha, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Rueter, Jaimie K, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S, Williams, John P, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Wen, Jenny, O’Brien, Zhihong, Saunders, John

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A pharmacokinetic evaluation of five H 1 antagonists after an oral and intravenous microdose to human subjects by Madan, Ajay, O'Brien, Zhihong, Wen, Jianyun, O'Brien, Chris, Farber, Robert H., Beaton, Graham, Crowe, Paul, Oosterhuis, Berend, Garner, R. Colin, Lappin, Graham, Bozigian, Haig P.

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Novel benzothiophene H 1-antihistamines for the treatment of insomnia by Moree, Wilna J., Jovic, Florence, Coon, Timothy, Yu, Jinghua, Li, Bin-Feng, Tucci, Fabio C., Marinkovic, Dragan, Gross, Raymond S., Malany, Siobhan, Bradbury, Margaret J., Hernandez, Lisa M., O’Brien, Zhihong, Wen, Jianyun, Wang, Hua, Hoare, Samuel R.J., Petroski, Robert E., Sacaan, Aida, Madan, Ajay, Crowe, Paul D., Beaton, Graham

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2-Amino-N-pyrimidin-4-ylacetamides as A2A Receptor Antagonists: 2. Reduction of hERG Activity, Observed Species Selectivity, and Structure−Activity Relationships by Slee, Deborah H, Moorjani, Manisha, Zhang, Xiaohu, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Rueter, Jaimie K, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S, Williams, John P, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Wen, Jenny, O’Brien, Zhihong, Petroski, Robert, Saunders, John

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N-[6-Amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A Receptor Antagonists with Improved Drug Like Properties and in Vivo Efficacy by Lanier, Marion C, Moorjani, Manisha, Luo, Zhiyong, Chen, Yongsheng, Lin, Emily, Tellew, John E, Zhang, Xiaohu, Williams, John P, Gross, Raymond S, Lechner, Sandra M, Markison, Stacy, Joswig, Tanya, Kargo, William, Piercey, Jaime, Santos, Mark, Malany, Siobhan, Zhao, Marilyn, Petroski, Robert, Crespo, María I, Díaz, José-Luis, Saunders, John, Wen, Jenny, O’Brien, Zhihong, Jalali, Kayvon, Madan, Ajay, Slee, Deborah H

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Abstract 4060: Discovery and preclinical development of KRAS-targeting siRNA therapeutic modality for the treatment of pancreatic cancer by OBrien, Zhihong (Julie), Wang, Li, Cina, Cima, Majeti, Bharat, Chu, James, Wang, Xiaoen, Baclig, Robiel, Lin, James, Ibarra, Jose, Chatterjee, Dhrubamitra, Jin, Jung-Kang, Clamme, Jean-Pierre, Daniels, Jennifer, Wang, Hai, Harborth, Jens, Ying, Wenbin

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Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2- c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists by Chen, Mi, Guo, Zhiqiang, Lanier, Marion C., Zhao, Liren, Betz, Stephen F., Huang, Charles Q., Loweth, Colin J., Ashweek, Neil J., Liu, Xin-Jun, Struthers, R. Scott, Bradbury, Margaret J., Behan, James W., Wen, Jenny, O’Brien, Zhihong, Saunders, John, Zhu, Yun-Fei

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Novel benzothiophene H sub(1)-antihistamines for the treatment of insomnia by Moree, Wilna J, Jovic, Florence, Coon, Timothy, Yu, Jinghua, Li, Bin-Feng, Tucci, Fabio C, Marinkovic, Dragan, Gross, Raymond S, Malany, Siobhan, Bradbury, Margaret J, Hernandez, Lisa M, O'Brien, Zhihong, Wen, Jianyun, Wang, Hua, Hoare, Samuel RJ, Petroski, Robert E, Sacaan, Aida, Madan, Ajay, Crowe, Paul D, Beaton, Graham

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N-[6-Amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2AReceptor Antagonists with Improved Drug Like Properties and in Vivo Efficacy by LANIER, Marion C, MOORJANI, Manisha, MARKISON, Stacy, JOSWIG, Tanya, KARGO, William, PIERCEY, Jaime, SANTOS, Mark, MALANY, Siobhan, ZHAO, Marilyn, PETROSKI, Robert, CRESPO, Maria I, DIAZ, Jose-Luis, ZHIYONG LUO, SAUNDERS, John, WEN, Jenny, O'BRIEN, Zhihong, JALALI, Kayvon, MADAN, Ajay, SLEE, Deborah H, YONGSHENG CHEN, LIN, Emily, TELLEW, John E, XIAOHU ZHANG, WILLIAMS, John P, GROSS, Raymond S, LECHNER, Sandra M

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A pharmacokinetic evaluation of five H(1) antagonists after an oral and intravenous microdose to human subjects by Madan, Ajay, O'Brien, Zhihong, Wen, Jianyun, O'Brien, Chris, Farber, Robert H, Beaton, Graham, Crowe, Paul, Oosterhuis, Berend, Garner, R Colin, Lappin, Graham, Bozigian, Haig P

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