Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)‑γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate by Evans, Catherine A, Liu, Tao, Lescarbeau, André, Nair, Somarajan J, Grenier, Louis, Pradeilles, Johan A, Glenadel, Quentin, Tibbitts, Thomas, Rowley, Ann M, DiNitto, Jonathan P, Brophy, Erin E, O’Hearn, Erin L, Ali, Janid A, Winkler, David G, Goldstein, Stanley I, O’Hearn, Patrick, Martin, Christian M, Hoyt, Jennifer G, Soglia, John R, Cheung, Culver, Pink, Melissa M, Proctor, Jennifer L, Palombella, Vito J, Tremblay, Martin R, Castro, Alfredo C

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Evaluation of Protein Kinase cAMP-Activated Catalytic Subunit Alpha as a Therapeutic Target for Fibrolamellar Carcinoma by Schalm, Stefanie S., O’Hearn, Erin, Wilson, Kevin, LaBranche, Timothy P., Silva, Grace, Zhang, Zhuo, DiPietro, Lucian, Bifulco, Neil, Woessner, Richard, Stransky, Nicolas, Sappal, Darshan, Campbell, Robert, Lobbardi, Riadh, Palmer, Michael, Kim, Joseph, Ye, Chaoyang, Dorsch, Marion, Lengauer, Christoph, Guzi, Timothy, Kadambi, Vivek, Garner, Andrew, Hoeflich, Klaus P.

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Abstract 1717: MAP4K1 inhibition enhances immune cell activation and anti-tumor immunity in preclinical tumor models by Faia, Kerrie, Toso, Alberto, Fetalvero, Kristina, Roche, Marly, Bench, Steven, O'Hearn, Erin, Cao, Qiongfang, Bright, Kerry-Ann, Paduraru, Debora, Romagnani, Andrea, Weng, Weifan, Zimmermann, Tina, Burke, Michael, Close, Joshua, Green, Luke, Kim, Joseph, Miduturu, Chandra, Ribeiro, Alison, Bacac, Marina, Herter, Sylvia, Perola, Emanuele, Sheets, Michael, Eckmann, Jan, Heidkamp, Gordon, Traore, Tary, Gerson, Erik, Woessner, Rich, Wolter, Carsten, Scheuplein, Felix, Perez, Nisha, LaBranche, Timothy, Silva, Grace, Ye, Chaoyang, Utt, Caitlin, Gross, Stefan, Bischoff, James R., Dorsch, Marion, Guzi, Tim, Hoeflich, Klaus, Brubaker, Jason

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Abstract B168: Identification of STX-241, a CNS-penetrant and mutant-selective EGFR inhibitor with activity on osimertinib-resistant C797x mutations by Pagliarini, Raymond A, Milgram, Benjamin C, Borrelli, Deanna R, O'Hearn, Erin, Huff, Michael R., Ladd, Brendon, Brooijmans, Natasja, Wang, Weixue, Kuzmic, Petr, Guzman-Perez, Angel, Stuart, Darrin D

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Abstract B127: Evaluating PRKACA as a therapeutic target for Fibrolamellar Carcinoma by Schalm, Stefanie S, O’Hearn, Erin, Wilson, Kevin, LaBranche, Timothy, Silva, Grace, DiPietro, Lucian, Bifulco, Neil, Woessner, Richard, Stransky, Nicolas, Sappal, Darshan, Shutes, Adam, Campbell, Robert, Lobbardi, Riadh, Palmer, Michael, Kim, Joseph, Miller, Stephen, Dorsch, Marion, Lengauer, Christoph, Guzi, Timothy, Kadambi, Vivek, Garner, Andrew, Hoeflich, Klaus P

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Ten best practices to strengthen stewardship and sharing of water science data in Canada by Persaud, Bhaleka D., Dukacz, Krysha A., Saha, Gopal C., Peterson, Amber, Moradi, Laleh, O'Hearn, Stephen, Clary, Erin, Mai, Juliane, Steeleworthy, Michael, Venkiteswaran, Jason J., Kheyrollah Pour, Homa, Wolfe, Brent B., Carey, Sean K., Pomeroy, John W., DeBeer, Chris M., Waddington, James M., Van Cappellen, Philippe, Lin, Jimmy

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Abstract 1891: Pharmacological target validation studies of fatty acid synthase in carcinoma using the potent, selective and orally bioavailable inhibitor IPI-9119 by Brophy, Erin, Conley, James, O'Hearn, Patrick, Douglas, Mark, Cheung, Culver, Coco, John, D'Anello, Laura, Wylie, Andrew, Tibbitts, Thomas, Keaney, Gregg, Chan, Lawrence, Bahadoor, Adilah, Snyder, Dan, Nevalainen, Marta, Castro, Alfredo, Palombella, Vito, Loda, Massimo, Peluso, Stephane

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