P450: PRECLINICAL AND CLINICAL SIGNS OF RVU120 EFFICACY, A SPECIFIC CDK8/19 INHIBITOR IN DNMT3A MUTATION POSITIVE AML AND HR‐MDS by Pakulska, U., Angelosanto, N., Mikula, M., Nogai, H., Dudziak, R., Abboud, C., Obacz, M., Goller, K., Cybulska, M., Mazan, M., Kozakowska, M., Rzymski, T.

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Development of selective MELK kinase inhibitors for breast cancer treatment by Wegrzyn, P, Kowalczyk, P, Dobrzanska, M, Knop, M, Obacz, M, Gluza, K, Commandeur, C, Sabiniarz, A, Wiklik, K, Golas, A, Vaillancourt, F, Larsen, N, Wang, J, Reynolds, D, Ito, D, Zou, J, Aicher, M, Smith, P, Zhu, P, Brzozka, K

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453 - Development of selective MELK kinase inhibitors for breast cancer treatment by Wegrzyn, P., Kowalczyk, P., Dobrzanska, M., Knop, M., Obacz, M., Gluza, K., Commandeur, C., Sabiniarz, A., Wiklik, K., Golas, A., Vaillancourt, F., Larsen, N., Wang, J., Reynolds, D., Ito, D., Zou, J., Aicher, M., Smith, P., Zhu, P., Brzozka, K.

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Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy by Logue, Susan E., McGrath, Eoghan P., Cleary, Patricia, Greene, Stephanie, Mnich, Katarzyna, Almanza, Aitor, Chevet, Eric, Dwyer, Róisín M., Oommen, Anup, Legembre, Patrick, Godey, Florence, Madden, Emma C., Leuzzi, Brian, Obacz, Joanna, Zeng, Qingping, Patterson, John B., Jäger, Richard, Gorman, Adrienne M., Samali, Afshin

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Biological basis for novel mesothelioma therapies by Obacz, Joanna, Yung, Henry, Shamseddin, Marie, Linnane, Emily, Liu, Xiewen, Azad, Arsalan A., Rassl, Doris M., Fairen-Jimenez, David, Rintoul, Robert C., Nikolić, Marko Z., Marciniak, Stefan J.

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Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation by Maurel, Marion, Obacz, Joanna, Avril, Tony, Ding, Yong‐Ping, Papadodima, Olga, Treton, Xavier, Daniel, Fanny, Pilalis, Eleftherios, Hörberg, Johanna, Hou, Wenyang, Beauchamp, Marie‐Claude, Tourneur‐Marsille, Julien, Cazals‐Hatem, Dominique, Sommerova, Lucia, Samali, Afshin, Tavernier, Jan, Hrstka, Roman, Dupont, Aurélien, Fessart, Delphine, Delom, Frédéric, Fernandez‐Zapico, Martin E, Jansen, Gregor, Eriksson, Leif A, Thomas, David Y, Jerome‐Majewska, Loydie, Hupp, Ted, Chatziioannou, Aristotelis, Chevet, Eric, Ogier‐Denis, Eric

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Novel Clinically Useful Inhibitor of Mediator Complex, RVU120, Relives Differentiation Block in MDS/AML by Ajibade, Opeyemi, Pakulska, Urszula, Rabinovich, Emma, Fromowitz, Ariel, Sahu, Srabani, Aminov, Sarah, Ramachandra, Nandini, Aluri, Srinivas, Gordon Mitchell, Shanisha, Carbajal, Milagros, Keska-Izworska, Kinga, Combik, Michał, Obacz, Marta, Adamczyk, Elżbieta, Zaucha, Jan M., Zarzycka, Ewa, Juszczynski, Przemyslaw, Boultwood, Jacqueline, Pellagatti, Andrea, Pradhan, Kith, Steidl, Ulrich, Shastri, Aditi, Zhao, Rongbao, Mazan, Milena, Rzymski, Tomasz, Verma, Amit

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Multiomics Analysis Confirms Effective Target Engagement for RVU120 - a First-in-Class CDK8/19 Kinase Inhibitor in AML and MR-MDS Patients and Reveals the Mechanism of Action by Rzymski, Tomasz, Sroka-Porada, Agnieszka, Kozakowska, Magdalena, Głowniak-Kwitek, Urszula, Bukowska-Strakova, Karolina, Obacz, Marta, Littlewood, Peter, Kuś, Kamil, Goller, Kristina, Kęska, Kinga, Pakulska, Urszula, Kozłowska-Tomczyk, Kamila, Madej, Monika, Mazan, Milena, Juszczynski, Przemyslaw, Zaucha, Jan M., Zarzycka, Agnieszka, Angelosanto, Noemi, Nogai, Hendrik, Brzózka, Krzysztof

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Clinique de l’enfance d’une population d’adultes schizophrènes. Étude rétrospective à propos de 50 cas by Obacz, C., Jay, N., Ligier, F., Kabuth, B.

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