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The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C
by
D'Arcy, Brandon M
,
Swingle, Mark R
,
Papke, Cinta M
,
Abney, Kevin A
,
Bouska, Erin S
,
Prakash, Aishwarya
,
Honkanen, Richard E
Published in
Molecular cancer therapeutics
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Quantitative proteomics and phosphoproteomics of PP2A-PPP2R5D variants reveal deregulation of RPS6 phosphorylation via converging signaling cascades
by
Smolen, Kali A.
,
Papke, Cinta M.
,
Swingle, Mark R.
,
Musiyenko, Alla
,
Li, Chenchen
,
Salter, E. Alan
,
Camp, Ashley D.
,
Honkanen, Richard E.
,
Kettenbach, Arminja N.
Published in
The Journal of biological chemistry
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A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth
by
Papke, Cinta M.
,
Smolen, Kali A.
,
Swingle, Mark R.
,
Cressey, Lauren
,
Heng, Richard A.
,
Toporsian, Mourad
,
Deng, Liyong
,
Hagen, Jacob
,
Shen, Yufeng
,
Chung, Wendy K.
,
Kettenbach, Arminja N.
,
Honkanen, Richard E.
Published in
The Journal of biological chemistry
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Journal Of Biological Chemistry/The Journal Of Biological Chemistry
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Molecular Cancer Therapeutics
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Life Sciences & Biomedicine
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Science & Technology
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Biochemistry & Molecular Biology
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Humans
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Jordan’s Syndrome
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Phosphatase
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Pp2A
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Ppp2R5D
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Ppp2R5D-Related Neurodevelopmental Disorder
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Protein Phosphatase 2 - Genetics
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Abnormalities, Multiple - Metabolism
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Abnormalities, Multiple - Pathology
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Akt-Mtor
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Amino Acid Sequence - Genetics
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Autism Spectrum Disorder
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Bridged Bicyclo Compounds, Heterocyclic - Chemistry
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Catalytic Domain - Drug Effects
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