Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload by Tiberghien, Arnaud C, Levy, Jean-Noel, Masterson, Luke A, Patel, Neki V, Adams, Lauren R, Corbett, Simon, Williams, David G, Hartley, John A, Howard, Philip W

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Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates by Hinrichs, Mary Jane Masson, Ryan, Pauline M, Zheng, Bo, Afif-Rider, Shameen, Yu, Xiang Qing, Gunsior, Michele, Zhong, Haihong, Harper, Jay, Bezabeh, Binyam, Vashisht, Kapil, Rebelatto, Marlon, Reed, Molly, Ryan, Patricia C, Breen, Shannon, Patel, Neki, Chen, Cui, Masterson, Luke, Tiberghien, Arnaud, Howard, Phillip W, Dimasi, Nazzareno, Dixit, Rakesh

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TR1801‐ADC: a highly potent cMet antibody–drug conjugate with high activity in patient‐derived xenograft models of solid tumors by Gymnopoulos, Marco, Betancourt, Oscar, Blot, Vincent, Fujita, Ryo, Galvan, Diana, Lieuw, Vincent, Nguyen, Sophie, Snedden, Jeanette, Stewart, Christine, Villicana, Jose, Wojciak, Jon, Wong, Eley, Pardo, Raul, Patel, Neki, D’Hooge, Francois, Vijayakrishnan, Balakumar, Barry, Conor, Hartley, John A., Howard, Philip W., Newman, Roland, Coronella, Julia

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Synthesis and evaluation of pyrrolobenzodiazepine dimer antibody-drug conjugates with dual β-glucuronide and dipeptide triggers by Gregson, Stephen J., Barrett, Allison M., Patel, Neki V., Kang, Gyoung-Dong, Schiavone, Davide, Sult, Erin, Barry, Conor S., Vijayakrishnan, Balakumar, Adams, Lauren R., Masterson, Luke A., D'Hooge, Francois, Snaith, Mike, Harper, Jay, Hartley, John A., Howard, Philip W.

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Synthesis and in vitro evaluation of SG3227, a pyrrolobenzodiazepine dimer antibody-drug conjugate payload based on sibiromycin by Kemp, Gary C., Tiberghien, Arnaud C., Patel, Neki V., D'Hooge, Francois, Nilapwar, Sanjay M., Adams, Lauren R., Corbett, Simon, Williams, David G., Hartley, John A., Howard, Philip W.

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Microfluidic Mobility Shift Assay for Real-Time Analysis of Peptide N-Palmitoylation by Lanyon-Hogg, Thomas, Patel, Neki V., Ritzefeld, Markus, Boxall, Katherine J., Burke, Rosemary, Blagg, Julian, Magee, Anthony I., Tate, Edward W.

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A Reactive Antibody Platform for One-Step Production of Antibody–Drug Conjugates through a Diels–Alder Reaction with Maleimide by St. Amant, Andre H, Huang, Fengying, Lin, Jia, Lemen, Daniel, Chakiath, Chacko, Mao, Shenlan, Fazenbaker, Christine, Zhong, Haihong, Harper, Jay, Xu, Wenshu, Patel, Neki, Adams, Lauren, Vijayakrishnan, Balakumar, Howard, Philip W, Marelli, Marcello, Wu, Herren, Gao, Changshou, Read de Alaniz, Javier, Christie, R. James

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An optimised synthesis of SG3376, a non-cleavable antibody-drug conjugate pyrrolobenzodiazepine drug-linker by Tiberghien, Arnaud C., Gregson, Stephen J., Masterson, Luke A., Levy, Jean-Noel, Kemp, Gary C., Adams, Lauren R., Patel, Neki V., Howard, Philip W.

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Abstract 225: TR1801-ADC, an optimized anti cMet PBD ADC with high efficacy in solid tumors of the GI tract and head & neck cancer by Gymnopoulos, Marco, Betancourt, Oscar, Blot, Vincent, Fujita, Ryo, Ly, Diana, Nguyen, Sophie, Snedden, Jeanette, Villicana, Jose, Wojciak, Jon, Wong, Eley, Patel, Neki, D'Hooge, Francois, Vijayakrishnan, Balakumar, Barry, Conor, Hartley, John A., Howard, Phil W., Newman, Roland, Coronella, Julia

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Abstract LB025: First disclosure of AZD5335, a TOP1i-ADC targeting low and high FRα-expressing ovarian cancer with superior preclinical activity vs FRα-MTI ADC by Gymnopoulos, Marco, Thomas, Tima, Gasper, Diana, Anderton, Judith, Tammali, Ravinder, Rosfjord, Ed, Durham, Nick, Ward, Chris, Myers, Claire, Wang, Jixin, Zhong, Wenyan, Christ, Simon, Meinecke, Lina, Nekolla, Katharina, Monasor, Laura Sebastian, Dodd, Roger, Patel, Neki, Albertella, Mark, Zeron-Medina, Jorge, Fraenkel, Paula, Sapra, Puja

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Prediction of heating cycle time in Rotational Moulding by Ramkumar, P.L., Ramesh, Anuraag, Alvenkar, Param Prabhu, Patel, Neki

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