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Oral FXIIa inhibitor KV998086 suppresses FXIIa and single chain FXII mediated kallikrein kinin system activation
by
Clermont, Allen C
,
Murugesan, Nivetha
,
Edwards, Hannah J
,
Lee, Daniel K
,
Bayliss, Natasha P
,
Duckworth, Edward J
,
Pethen, Stephen J
,
Hampton, Sally L
,
Gailani, David
,
Feener, Edward P
Published in
Frontiers in pharmacology
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Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedem...
by
Davie, Rebecca L.
,
Edwards, Hannah J.
,
Evans, D. Michael
,
Hodgson, Simon T.
,
Stocks, Michael J.
,
Smith, Alun J.
,
Rushbrooke, Louise J.
,
Pethen, Stephen J.
,
Roe, Michael B.
,
Clark, David E.
,
McEwan, Paul A.
,
Hampton, Sally L.
Published in
Journal of medicinal chemistry
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Sebetralstat: A Rapidly Acting Oral Plasma Kallikrein Inhibitor for the On-Demand Treatment of Hereditary Angioedema
by
Feener, Edward P.
,
Davie, Rebecca L.
,
Murugesan, Nivetha
,
Pethen, Stephen J.
,
Hampton, Sally L.
,
Smith, Michael D.
,
Audhya, Paul K.
,
Yea, Chris M.
Published in
Drugs and drug candidates
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Frontiers In Pharmacology
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Hereditary Angioedema
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Factor Xiia Inhibitor
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Kallikrein Kinin System
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