2-Arylbenzoxazoles as CETP inhibitors: Raising HDL-C in cynoCETP transgenic mice by Kallashi, Florida, Kim, Dooseop, Kowalchick, Jennifer, Park, You Jung, Hunt, Julianne A., Ali, Amjad, Smith, Cameron J., Hammond, Milton L., Pivnichny, James V., Tong, Xinchun, Xu, Suoyu S., Anderson, Matt S., Chen, Ying, Eveland, Suzanne S., Guo, Qiu, Hyland, Sheryl A., Milot, Denise P., Cumiskey, Anne-Marie, Latham, Melanie, Peterson, Laurence B., Rosa, Raymond, Sparrow, Carl P., Wright, Samuel D., Sinclair, Peter J.

Get full text

Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase by Stelmach, John E., Liu, Luping, Patel, Sangita B., Pivnichny, James V., Scapin, Giovanna, Singh, Suresh, Hop, Cornelis E.C.A., Wang, Zhen, Strauss, John R., Cameron, Patricia M., Nichols, Elizabeth A., O'Keefe, Stephen J., O'Neill, Edward A., Schmatz, Dennis M., Schwartz, Cheryl D., Thompson, Chris M., Zaller, Dennis M., Doherty, James B.

Get full text

Effect of Signal Interference from Dosing Excipients on Pharmacokinetic Screening of Drug Candidates by Liquid Chromatography/Mass Spectrometry by Tong, Xinchun S, Wang, Junying, Zheng, Song, Pivnichny, James V, Griffin, Patrick R, Shen, Xiaolan, Donnelly, Marcie, Vakerich, Ken, Nunes, Chris, Fenyk-Melody, Judy

Get full text

Biphenyl-Substituted Oxazolidinones as Cholesteryl Ester Transfer Protein Inhibitors: Modifications of the Oxazolidinone Ring Leading to the Discovery of Anacetrapib by Smith, Cameron J, Ali, Amjad, Hammond, Milton L, Li, Hong, Lu, Zhijian, Napolitano, Joann, Taylor, Gayle E, Thompson, Christopher F, Anderson, Matt S, Chen, Ying, Eveland, Suzanne S, Guo, Qiu, Hyland, Sheryl A, Milot, Denise P, Sparrow, Carl P, Wright, Samuel D, Cumiskey, Anne-Marie, Latham, Melanie, Peterson, Laurence B, Rosa, Ray, Pivnichny, James V, Tong, Xinchun, Xu, Suoyu S, Sinclair, Peter J

Get full text

2-Arylbenzoxazoles as CETP inhibitors: Substitution and modification of the α-alkoxyamide moiety by Hunt, Julianne A., Gonzalez, Silvia, Kallashi, Florida, Hammond, Milton L., Pivnichny, James V., Tong, Xinchun, Xu, Suoyu S., Anderson, Matt S., Chen, Ying, Eveland, Suzanne S., Guo, Qiu, Hyland, Sheryl A., Milot, Denise P., Sparrow, Carl P., Wright, Samuel D., Sinclair, Peter J.

Get full text

High throughput metabolic stability screen for lead optimization in drug discovery by Tong, Xinchun S., Xu, Suoyu, Zheng, Song, Pivnichny, James V., Martin, Jesus, Dufresne, Claude

Get full text

The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection by Xiong, Yusheng, Wiltsie, Judyann, Woods, Andrea, Guo, Jian, Pivnichny, James V., Tang, Wei, Bansal, Alka, Cummings, Richard T., Cunningham, Barry R., Friedlander, Arthur M., Douglas, Cameron M., Salowe, Scott P., Zaller, Dennis M., Scolnick, Edward M., Schmatz, Dennis M., Bartizal, Kenneth, Hermes, Jeffrey D., MacCoss, Malcolm, Chapman, Kevin T.

Get full text

A simple in vitro model to study the stability of acylglucuronides by Chen, Zhesheng, Holt, Tom G., Pivnichny, James V., Leung, Kwan

Get full text

p38 Inhibitors: piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones by Hunt, Julianne A, Kallashi, Florida, Ruzek, Rowena D, Sinclair, Peter J, Ita, Ida, McCormick, Sherrie X, Pivnichny, James V, Hop, C.E.C.A, Kumar, Sanjeev, Wang, Zhen, O'Keefe, Stephen J, O'Neill, Edward A, Porter, Gene, Thompson, James E, Woods, Andrea, Zaller, Dennis M, Doherty, James B

Get full text

High-throughput pharmacokinetics screen of VLA-4 antagonists by LC/MS/MS coupled with automated solid-phase extraction sample preparation by Tong, Xinchun S, Wang, Junying, Zheng, Song, Pivnichny, James V

Get full text

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds by SHEN, Dong-Ming, MIN SHU, GOULD, Sandra L, DEMARTINO, Julie A, SICILIANO, Salvatore J, LYONS, Kathy, PIVNICHNY, James V, KWEI, Gloria Y, CARELLA, Anthony, CARVER, Gwen, HOLMES, Karen, SCHLEIF, William A, WILLOUGHBY, Christopher A, DANZEISEN, Renee, HAZUDA, Daria, KESSLER, Joseph, LINEBERGER, Janet, MILLER, Michael D, EMINI, Emilio A, SHAH, Shrenik, LYNCH, Christopher L, HALE, Jeffrey J, MILLS, Sander G, CHAPMAN, Kevin T, MALKOWITZ, Lorraine, SPRINGER, Martin S

Get full text

p38 MAP kinase inhibitors: Metabolically stabilized piperidine-substituted quinolinones and naphthyridinones by Bao, Jianming, Hunt, Julianne A., Miao, Shouwu, Rupprecht, Kathleen M., Stelmach, John E., Liu, Luping, Ruzek, Rowena D., Sinclair, Peter J., Pivnichny, James V., Hop, Cornelis E.C.A., Kumar, Sanjeev, Zaller, Dennis M., Shoop, Wesley L., O’Neill, Edward A., O’Keefe, Stephen J., Thompson, Chris M., Cubbon, Rose M., Wang, Ruixiu, Zhang, Wen Xiao, Thompson, James E., Doherty, James B.

Get full text

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment by MIN SHU, LOEBACH, Jennifer L, SICILIANO, Salvatore J, DI SALVO, Jerry, LYONS, Kathy, PIVNICHNY, James V, KWEI, Gloria Y, CARELLA, Anthony, CARVER, Gwen, HOLMES, Karen, SCHLEIF, William A, DANZEISEN, Renee, PARKER, Kerry A, HAZUDA, Daria, KESSLER, Joseph, LINEBERGER, Janet, MILLER, Michael D, EMINI, Emilio A, MILLS, Sander G, CHAPMAN, Kevin T, SHEN, Dong-Ming, MALKOWITZ, Lorraine, SPRINGER, Martin S, GOULD, Sandra L, DEMARTINO, Julie A

Get full text

Simple and sensitive liquid chromatography/tandem mass spectrometry method for the determination of diazepam and its major metabolites in rat cerebrospinal fluid by Wang, Junying, Shen, Xiaolan, Fenyk-Melody, Judy, Pivnichny, James V., Tong, Xinchun

Get full text

Rapid pharmacokinetic screening for the selection of new drug discovery candidates using a generic isocratic liquid chromatography–atmospheric pressure ionization tandem mass spect... by Colwell, Lawrence F., Tamvakopoulos, Constantin S., Wang, Pei Ran, Pivnichny, James V., Shih, Thomas L.

Get full text

Synthesis of Nodulisporic Acid 2‘ ‘-Oxazoles and 2‘ ‘-Thiazoles by Berger, Richard, Shoop, Wesley L, Pivnichny, James V, Warmke, Lynn M, Zakson-Aiken, Michelle, Owens, Karen A, deMontigny, Pierre, Schmatz, Dennis M, Wyvratt, Matthew J, Fisher, Michael H, Meinke, Peter T, Colletti, Steven L

Get full text

Potent, orally absorbed glucagon receptor antagonists by de Laszlo, Stephen E., Hacker, Candice, Li, Bing, Kim, Dooseop, MacCoss, Malcolm, Mantlo, Nathan, Pivnichny, James V., Colwell, Larry, Koch, Gregory E., Cascieri, Margaret A., Hagmann, William K.

Get full text

Discovery of N-{N-[(3-Cyanophenyl)sulfonyl]-4(R)-cyclobutylamino-(l)-prolyl}-4-[(3′,5′-dichloroisonicotinoyl)amino]-(l)-phenylalanine (MK-0668), an Extremely Potent and Orally Acti... by Lin, Linus S, Lanza, Thomas, Jewell, James P, Liu, Ping, Jones, Carrie, Kieczykowski, Gerard R, Treonze, Kelly, Si, Qian, Manior, Salony, Koo, Gloria, Tong, Xinchun, Wang, Junying, Schuelke, Anne, Pivnichny, James, Wang, Regina, Raab, Conrad, Vincent, Stella, Davies, Philip, MacCoss, Malcolm, Mumford, Richard A, Hagmann, William K

Get full text

Base-catalyzed isomerization of avermectins by Pivnichny, James V, Arison, Byron H, Preiser, Franz A, Shim, Jung Sook K, Mrozik, Helmut

Get full text

2-Arylbenzoxazoles as CETP inhibitors: Substitution and modification of the a-alkoxyamide moiety by Hunt, Julianne A, Gonzalez, Silvia, Kallashi, Florida, Hammond, Milton L, Pivnichny, James V, Tong, Xinchun, Xu, Suoyu S, Anderson, Matt S, Chen, Ying, Eveland, Suzanne S, Guo, Qiu, Hyland, Sheryl A, Milot, Denise P, Sparrow, Carl P, Wright, Samuel D, Sinclair, Peter J

Get full text