Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach by Beswick, Paul J., Blackaby, Andrew P., Bountra, Chas, Brown, Terry, Browning, Kerry, Campbell, Ian B., Corfield, John, Gleave, Robert J., Guntrip, Steve B., Hall, Richard M., Hindley, Sean, Lambeth, Paul F., Lucas, Fiona, Mathews, Neil, Naylor, Alan, Player, Hazel, Price, Helen S., Sidebottom, Phillip J., Taylor, Nicholas L., Webb, Graham, Wiseman, Joanne

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Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors by BESWICK, Paul, BINGHAM, Sharon, GUNTRIP, Stephen, HASLAM, Claudine, LAMBETH, Paul, LUCAS, Fiona, MATHEWS, Neil, MURKIT, Graham, NAYLOR, Alan, PEGG, Neil, PICKUP, Elizabeth, PLAYER, Hazel, BOUNTRA, Chas, PRICE, Helen, STEVENS, Alexander, STRATTON, Sharon, WISEMAN, Joanne, BROWN, Terry, BROWNING, Kerry, CAMPBELL, Ian, CHESSELL, Lain, CLAYTON, Nick, COLLINS, Sue, CORFIELD, John

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