Discovery of Clinical Candidate 2‑((2S,6S)‑2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3′-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid D... by Ye, Xiang-Yang, Chen, Stephanie Y, Wu, Shung, Yoon, David S, Wang, Haixia, Hong, Zhenqiu, O’Connor, Stephen P, Li, Jun, Li, James J, Kennedy, Lawrence J, Walker, Steven J, Nayeem, Akbar, Sheriff, Steven, Camac, Daniel M, Ramamurthy, Vidyhashankar, Morin, Paul E, Zebo, Rachel, Taylor, Joseph R, Morgan, Nathan N, Ponticiello, Randolph P, Harrity, Thomas, Apedo, Atsu, Golla, Rajasree, Seethala, Ramakrishna, Wang, Mengmeng, Harper, Timothy W, Sleczka, Bogdan G, He, Bin, Kirby, Mark, Leahy, David K, Li, Jianqing, Hanson, Ronald L, Guo, Zhiwei, Li, Yi-Xin, DiMarco, John D, Scaringe, Raymond, Maxwell, Brad, Moulin, Frederick, Barrish, Joel C, Gordon, David A, Robl, Jeffrey A

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Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1) by Li, Jun, Kennedy, Lawrence J, Walker, Steven J, Wang, Haixia, Li, James J, Hong, Zhenqiu, O’Connor, Stephen P, Ye, Xiang-yang, Chen, Stephanie, Wu, Shung, Yoon, David S, Nayeem, Akbar, Camac, Daniel M, Ramamurthy, Vidhyashankar, Morin, Paul E, Sheriff, Steven, Wang, Mengmeng, Harper, Timothy W, Golla, Rajasree, Seethala, Ramakrishna, Harrity, Thomas, Ponticiello, Randolph P, Morgan, Nathan N, Taylor, Joseph R, Zebo, Rachel, Maxwell, Brad, Moulin, Frederick, Gordon, David A, Robl, Jeffrey A

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Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1) by Li, Jun, Kennedy, Lawrence J, Wang, Haixia, Li, James J, Walker, Steven J, Hong, Zhenqiu, O’Connor, Stephen P, Nayeem, Akbar, Camac, Daniel M, Morin, Paul E, Sheriff, Steven, Wang, Mengmeng, Harper, Timothy, Golla, Rajasree, Seethala, Ramakrishna, Harrity, Thomas, Ponticiello, Randolph P, Morgan, Nathan N, Taylor, Joseph R, Zebo, Rachel, Gordon, David A, Robl, Jeffrey A

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Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11β-hydroxydehydrogenase 1 (11β-HSD1) by Wu, Shung C., Yoon, David, Chin, Janice, van Kirk, Katy, Seethala, Ramakrishna, Golla, Rajasree, He, Bin, Harrity, Thomas, Kunselman, Lori K., Morgan, Nathan N., Ponticiello, Randolph P., Taylor, Joseph R., Zebo, Rachel, Harper, Timothy W., Li, Wenying, Wang, Mengmeng, Zhang, Lisa, Sleczka, Bogdan G., Nayeem, Akbar, Sheriff, Steven, Camac, Daniel M., Morin, Paul E., Everlof, John G., Li, Yi-Xin, Ferraro, Cheryl A., Kieltyka, Kasia, Shou, Wilson, Vath, Marianne B., Zvyaga, Tatyana A., Gordon, David A., Robl, Jeffrey A.

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Discovery of 5‑Chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)‑one (BMS-903452), an Antidiabetic Clinical Candidate Targ... by Wacker, Dean A, Wang, Ying, Broekema, Matthias, Rossi, Karen, O’Connor, Steven, Hong, Zhenqiu, Wu, Ginger, Malmstrom, Sarah E, Hung, Chen-Pin, LaMarre, Linda, Chimalakonda, Anjaneya, Zhang, Lisa, Xin, Li, Cai, Hong, Chu, Cuixia, Boehm, Stephanie, Zalaznick, Jacob, Ponticiello, Randolph, Sereda, Larisa, Han, Song-Ping, Zebo, Rachel, Zinker, Bradley, Luk, Chiuwa Emily, Wong, Richard, Everlof, Gerry, Li, Yi-Xin, Wu, Chunyu K, Lee, Michelle, Griffen, Steven, Miller, Keith J, Krupinski, John, Robl, Jeffrey A

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Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11I super(2)-hydroxydehydrogenase 1 (11I super(2)-HSD1) by Wu, Shung C, Yoon, David, Chin, Janice, Van Kirk, Katy, Seethala, Ramakrishna, Golla, Rajasree, He, Bin, Harrity, Thomas, Kunselman, Lori K, Morgan, Nathan N, Ponticiello, Randolph P, Taylor, Joseph R, Zebo, Rachel, Harper, Timothy W, Li, Wenying, Wang, Mengmeng, Zhang, Lisa, Sleczka, Bogdan G, Nayeem, Akbar, Sheriff, Steven, Camac, Daniel M, Morin, Paul E, Everlof, John G, Li, Yi-Xin, Ferraro, Cheryl A, Kieltyka, Kasia, Shou, Wilson, Vath, Marianne B, Zvyaga, Tatyana A, Gordon, David A, Robl, Jeffrey A

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The dual peroxisome proliferator-activated receptor alpha/gamma activator muraglitazar prevents the natural progression of diabetes in db/db mice by Tozzo, Effie, Ponticiello, Randolph, Swartz, JoAnn, Farrelly, Dennis, Zebo, Rachel, Welzel, Gustav, Egan, Donald, Kunselman, Lori, Peters, Andrew, Gu, Liqun, French, Michele, Chen, Sean, Devasthale, Pratik, Janovitz, Evan, Staal, Ada, Harrity, Thomas, Belder, Rene, Cheng, Peter T, Whaley, Jean, Taylor, Simeon, Hariharan, Narayanan

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The Dual Peroxisome Proliferator-Activated Receptor α/γ Activator Muraglitazar Prevents the Natural Progression of Diabetes in db/db Mice by Effie Tozzo, Randolph Ponticiello, JoAnn Swartz, Dennis Farrelly, Rachel Zebo, Gustav Welzel, Donald Egan, Lori Kunselman, Andrew Peters, Liqun Gu, Michele French, Sean Chen, Pratik Devasthale, Evan Janovitz, Ada Staal, Thomas Harrity, Rene Belder, Peter T. Cheng, Jean Whaley, Simeon Taylor, Narayanan Hariharan

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