MCL1 inhibitor BRD-810 kills cancer cells while minimizing risk of cardiotoxicity

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Abstract LB_A01: Rapidly cleared MCL1 inhibitor TTX-810 showing robust efficacy in preclinical tumor models with no effects on cardiomyocytes in vitro and in vivo by Rauh, Ulrike, Kaushik, Virendar, Pilari, Sabine, Kosmidis, Georgios, Serrano-Wu, Michael, Wei, Guo, Zhang, Weiqun, Kaulfuss, Stefan, Thede, Kai, Poncet-Montange, Guillaume, Daniels, Douglas, Lemke, Christopher T, Hubbard, Brian, Golub, Todd R.

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Abstract B174: The non-covalent HCK/BTK inhibitor TTX-114 displays potent in vitro and in vivo anti-tumor activity in leukemia and lymphoma by Rauh, Ulrike, Serrano-Wu, Michael, Kaushik, Virendar, Pilari, Sabine, Ogahara, Ikuko, Kaneko, Akiko, Arribas, Alberto J, Cannas, Eleonora, Bertoni, Franceso, Javidi-Sharifi, Nathalie R, Davids, Matthew S, Fukami, Takehiro, Saito, Yoriko, Ishikawa, Fumihiko, Letai, Anthony, Hubbard, Brian

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BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models by Rauh, Ulrike, Wei, Guo, Serrano-Wu, Michael, Kosmidis, Georgios, Kaulfuss, Stefan, Siegel, Franziska, Thede, Kai, McFarland, James, Lemke, Christopher T., Werbeck, Nicolas, Nowak-Reppel, Katrin, Pilari, Sabine, Menz, Stephan, Ocker, Matthias, Zhang, Weiqun, Davis, Kyle, Poncet-Montange, Guillaume, Roth, Jennifer, Daniels, Douglas, Kaushik, Virendar K., Hubbard, Brian, Ziegelbauer, Karl, Golub, Todd R.

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Abstract 506: ANJ810 is a highly selective novel MCL1 inhibitor with optimized in vivo clearance showing robust efficacy in preclinical solid and hematological tumor models by Rauh, Ulrike, Wei, Guo, Serrano-Wu, Michael, Kosmidis, Georgios, Kaulfuss, Stefan, Siegel, Franziska, Thede, Kai, McFarland, James, Lemke, Christopher, Werbeck, Nicolas, Nowak-Reppel, Katrin, Pillari, Sabine, Menz, Stephan, Ocker, Matthias, Hubbard, Brian, Kaushik, Virendar, Ziegelbauer, Karl, Golub, Todd

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Agreement Between 24-Hour Salt Ingestion and Sodium Excretion in a Controlled Environment by Lerchl, Kathrin, Rakova, Natalia, Dahlmann, Anke, Rauh, Manfred, Goller, Ulrike, Basner, Mathias, Dinges, David F, Beck, Luis, Agureev, Alexander, Larina, Irina, Baranov, Victor, Morukov, Boris, Eckardt, Kai-Uwe, Vassilieva, Galina, Wabel, Peter, Vienken, Jörg, Kirsch, Karl, Johannes, Bernd, Krannich, Alexander, Luft, Friedrich C, Titze, Jens

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Arginase impedes the resolution of colitis by altering the microbiome and metabolome by Baier, Julia, Gänsbauer, Maximilian, Giessler, Claudia, Arnold, Harald, Muske, Mercedes, Schleicher, Ulrike, Lukassen, Sören, Ekici, Arif, Rauh, Manfred, Daniel, Christoph, Hartmann, Arndt, Schmid, Benjamin, Tripal, Philipp, Dettmer, Katja, Oefner, Peter J, Atreya, Raja, Wirtz, Stefan, Bogdan, Christian, Mattner, Jochen

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Long-Term Space Flight Simulation Reveals Infradian Rhythmicity in Human Na+ Balance by Rakova, Natalia, Jüttner, Kathrin, Dahlmann, Anke, Schröder, Agnes, Linz, Peter, Kopp, Christoph, Rauh, Manfred, Goller, Ulrike, Beck, Luis, Agureev, Alexander, Vassilieva, Galina, Lenkova, Liubov, Johannes, Bernd, Wabel, Peter, Moissl, Ulrich, Vienken, Jörg, Gerzer, Rupert, Eckardt, Kai-Uwe, Müller, Dominik N., Kirsch, Karl, Morukov, Boris, Luft, Friedrich C., Titze, Jens

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Endogenous Erythropoietin and the Association with Inflammation and Mortality in Diabetic Chronic Kidney Disease by Wagner, Martin, Alam, Ahsan, Zimmermann, Josef, Rauh, Katharina, Koljaja-Batzner, Angelika, Raff, Ulrike, Wanner, Christoph, Schramm, Lothar

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So werden PAVK-Patienten optimal betreut by Rauh, Günter, Mager, Ulrike

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Frontal theta oscillations during emotion regulation in people with borderline personality disorder by Haaf, Moritz, Polomac, Nenad, Starcevic, Ana, Lack, Marvin, Kellner, Stefanie, Dohrmann, Anna-Lena, Fuger, Ulrike, Steinmann, Saskia, Rauh, Jonas, Nolte, Guido, Mulert, Christoph, Leicht, Gregor

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Pulmonary Involvement in Pediatric-Onset Multisystem Langerhans Cell Histiocytosis: Effect on Course and Outcome by Ronceray, Leila, MD, Pötschger, Ulrike, PhD, Janka, Gritta, MD, Gadner, Helmut, MD, FRCP, Minkov, Milen, MD, PhD

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A Functional K + Channel from Tetraselmis Virus 1, a Member of the Mimiviridae by Kukovetz, Kerri, Hertel, Brigitte, Schvarcz, Christopher R, Saponaro, Andrea, Manthey, Mirja, Burk, Ulrike, Greiner, Timo, Steward, Grieg F, Van Etten, James L, Moroni, Anna, Thiel, Gerhard, Rauh, Oliver

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Safety and efficacy of a lifestyle intervention for pregnant women to prevent excessive maternal weight gain: a cluster-randomized controlled trial by Rauh, Kathrin, Gabriel, Elisabeth, Kerschbaum, Eva, Schuster, Tibor, von Kries, Ruediger, Amann-Gassner, Ulrike, Hauner, Hans

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Overall Survival and Patient-Reported Impairment by Fatigue, Pain and Treatment Time in Patients with Advanced Breast Cancer in Routine Practice: Results from the Prospective Germa... by Marschner, Norbert, Fietz, Thomas, Rauh, Jacqueline, Nusch, Arnd, Söling, Ulrike, Frank, Melanie, Kruggel, Lisa, Jänicke, Martina

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PO69 - Overall Survival and Patient-Reported Impairment by Fatigue, Pain and Treatment Time in Patients with Advanced Breast Cancer in Routine Practice: Results from the Prospectiv... by Marschner, Norbert, Fietz, Thomas, Rauh, Jacqueline, Nusch, Arnd, Söling, Ulrike, Frank, Melanie, Kruggel, Lisa, Jänicke, Martina

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Prenatal and family risks of children born to mothers with epilepsy: effects on cognitive development by Titze, Karl, Koch, Sabine, Helge, Hans, Lehmkuhl, Ulrike, Rauh, Hellgard, Steinhausen, Hans‐Christoph

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Checkpoint Inhibitor Monotherapy in Potentially Trial-Eligible or Trial-Ineligible Patients With Metastatic NSCLC in the German Prospective CRISP Registry Real-World Cohort (AIO-TR... by Eberhardt, Wilfried E.E., Brueckl, Wolfgang M., Jaeschke, Bastian, Kern, Jens, Fleitz, Annette, Hipper, Annette, Weichert, Wilko, Dörfel, Steffen, Petersen, Volker, Wilke, Jochen, Thomas, Michael, Alt, Jürgen, Anhuf, Jürgen, Bauer, Stefan, Berger, Winfried, Bernhardt, Christiane, Bertram, Mathias, Bruch, Harald-Robert, Christopoulos, Petros, Däßler, Klaus-Ulrich, de Wit, Maike, Dechow, Tobias, Dommach, Markus, Dörfel, Steffen, Eberhardt, Wilfried, Elender, Corinna, Elsel, Wolfgang, Flieger, Dimitri, Freidt, Anke, Freier, Werner, Frenzel, Christian, Gaska, Tobias, Gleiber, Wolfgang, Grah, Christian, Haas, Siegfried, Harich, Hanns-Detlev, Heilmann, Monika, Heinrich, Kathrin, Hering-Schubert, Christiane, Heßling, Jörg, Hoffknecht, Petra, Hortig, Patricia, Hübner, Gerdt, Hutzschenreuter, Ulrich, Illmer, Thomas, Innig, Georg, Jaeschke, Bastian, Kamal, Haytham, Kern, Jens, Kimmich, Martin, Kingreen, Dorothea, Klausmann, Martine, Kokowski, Konrad, Körber, Wolfgang, Krämer, Benoit, Lamberti, Christof, Leistner, Rumo David, Losem, Christoph, Lück, Andreas, Maintz, Christoph, Metzenmacher, Martin, Meyer zum Büschenfelde, Christian, Moorahrend, Enno, Müller, Annette, Müller, Lothar, Neise, Michael, Nusch, Arnd, Pelz, Henning, Petersen, Volker, Peuser, Bettina, Plath, Margarete, Rauh, Jacqueline, Reck, Martin, Reinmuth, Niels, Repp, Roland, Reschke, Daniel, Rittmeyer, Achim, Rodemer, Yolanda, Sackmann, Sandra, Sandner, Reiner, Schäfer, Harald, Schaudt, Christoph, Schmidt, Burkhard, Schmitz, Stephan, Schröder, Jan, Schroeder, Michael, Schulze, Mathias, Schumann, Christian, Schütte, Wolfgang, Schwaiblmair, Martin, Steiff, Johannes, Steiniger, Heike, Trarbach, Tanja, Waller, Cornelius, Weißenborn, Georg, Wermke, Martin, Wesseler, Claas, Wiegand, Jörg, Wilhelm, Stefan, Zeth, Matthias

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Agreement between twenty-four hour salt ingestion and sodium excretion in a controlled environment by Lerchl, Kathrin, Rakova, Natalia, Dahlmann, Anke, Rauh, Manfred, Goller, Ulrike, Basner, Mathias, Dinges, David F., Beck, Luis, Agureev, Alexander, Larina, Irina, Baranov, Victor, Morukov, Boris, Eckardt, Kai-Uwe, Vassilieva, Galina, Wabel, Peter, Vienken, Jörg, Kirsch, Karl, Johannes, Bernd, Krannich, Alexander, Luft, Friedrich C., Titze, Jens

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Inter-Laboratory Robustness of Next-Generation Bile Acid Study in Mice and Humans: International Ring Trial Involving 12 Laboratories by Pham, Hai T, Arnhard, Kathrin, Asad, Yasmin J, Deng, Lu, Felder, Thomas K, St John-Williams, Lisa, Kaever, Volkhard, Leadley, Michael, Mitro, Nico, Muccio, Stephane, Prehn, Cornelia, Rauh, Manfred, Rolle-Kampczyk, Ulrike, Thompson, J Will, Uhl, Olaf, Ulaszewska, Maria, Vogeser, Michael, Wishart, David S, Koal, Therese

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