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Phase 1b dose-escalation, safety, and pharmacokinetic study of IC14, a monoclonal antibody against CD14, for the treatment of amyotrophic lateral sclerosis
by
Henderson, Robert D.
,
Agosti, Jan M.
,
McCombe, Pamela A.
,
Thorpe, Kathryn
,
Heggie, Susan
,
Heshmat, Saman
,
Appleby, Mark W.
,
Ziegelaar, Brian W.
,
Crowe, David T.
,
Redlich, Garry L.
Published in
Medicine (Baltimore)
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Medicine
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Administration, Intravenous
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Amyotrophic Lateral Sclerosis
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Amyotrophic Lateral Sclerosis - Drug Therapy
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Anti-Cd14
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Antibodies, Monoclonal - Administration & Dosage
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Antibodies, Monoclonal - Adverse Effects
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Antibodies, Monoclonal - Pharmacokinetics
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Area Under Curve
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Atibuclimab
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Biomarkers
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Clinical Trial/Experimental Study
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Dose-Response Relationship, Drug
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General & Internal Medicine
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Half-Life
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Humans
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Ic14
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Life Sciences & Biomedicine
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Lipopolysaccharide Receptors
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Medicine, General & Internal
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Metabolic Clearance Rate
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