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Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4
by
Bumbaca, Daniela
,
Wong, Anne
,
Drake, Elizabeth
,
Reyes II, Arthur E.
,
Lin, Benjamin C.
,
Stephan, Jean-Philippe
,
Desnoyers, Luc
,
Shen, Ben-Quan
,
Dennis, Mark S.
Published in
mAbs
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Complex formation of anti‐VEGF‐C with VEGF‐C released during blood coagulation resulted in an artifact in its serum pharmacokinetics
by
Bumbaca Yadav, Daniela
,
Reyes, Arthur E.
,
Gupta, Priyanka
,
Vernes, Jean‐Michel
,
Meng, Y. Gloria
,
Schweiger, Michelle G.
,
Stainton, Shannon L.
,
Fuh, Germaine
,
Fielder, Paul J.
,
Kamath, Amrita V.
,
Shen, Ben‐Quan
Published in
Pharmacology research & perspectives
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Mabs
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Pharmacology Research & Perspectives
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Animals
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Antibodies, Monoclonal - Pharmacokinetics
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Humans
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Life Sciences & Biomedicine
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Mice, Nude
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Affinity Maturation
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Amino Acid Sequence
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Antibodies, Monoclonal - Blood
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Antibodies, Monoclonal - Chemistry
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Antibodies, Monoclonal - Immunology
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Antibodies, Monoclonal - Metabolism
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Antibodies, Monoclonal, Humanized - Chemistry
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Antibodies, Monoclonal, Humanized - Immunology
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Antibody Humanization
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Antineoplastic Agents - Chemistry
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