Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies by Condon, Stephen M, Mitsuuchi, Yasuhiro, Deng, Yijun, LaPorte, Matthew G, Rippin, Susan R, Haimowitz, Thomas, Alexander, Matthew D, Kumar, Pavan Tirunahari, Hendi, Mukta S, Lee, Yu-Hua, Benetatos, Christopher A, Yu, Guangyao, Kapoor, Gurpreet Singh, Neiman, Eric, Seipel, Martin E, Burns, Jennifer M, Graham, Martin A, McKinlay, Mark A, Li, Xiaochun, Wang, Jiawei, Shi, Yigong, Feltham, Rebecca, Bettjeman, Bodhi, Cumming, Mathew H, Vince, James E, Khan, Nufail, Silke, John, Day, Catherine L, Chunduru, Srinivas K

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The Discovery of Pyrano[3,4-b]indole-Based Allosteric Inhibitors of HCV NS5B Polymerase with In Vivo Activity by LaPorte, Matthew G., Jackson, Randy W., Draper, Tandy L., Gaboury, Janet A., Galie, Kristin, Herbertz, Torsten, Hussey, Alison R., Rippin, Susan R., Benetatos, Christopher A., Chunduru, Srinivas K., Christensen, Joel S., Coburn, Glen A., Rizzo, Christopher J., Rhodes, Gerry, O'Connell, John, Howe, Anita Y. M., Mansour, Tarek S., Collett, Marc S., Pevear, Daniel C., Young, Dorothy C., Gao, Tiejun, Tyrrell , D. Lorne J., Kneteman, Norman M., Burns, Christopher J., Condon, Stephen M.

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Process Development and Synthesis of Birinapant: Large Scale Preparation and Acid-Mediated Dimerization of the Key Indole Intermediate by Deng, Yijun, Xie, Qiuzhe, LaPorte, Matthew G, Chasnoff, Anna T. A, Mortensen, Mark A, Patra, Debasis, Putrelo, Seth A, Antonovich, Robert S, Cao, Hong, Yan, Jun, Cooper, Arthur J, Rippin, Susan R, Alexander, Matthew D, Kumar, Pavan Tirunahari, Hendi, Mukta S, Lee, Yu-Hua, Haimowitz, Thomas, Condon, Stephen M

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N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides:  Identification of Novel Orthopoxvirus Egress Inhibitors by Bailey, Thomas R, Rippin, Susan R, Opsitnick, Elizabeth, Burns, Christopher J, Pevear, Daniel C, Collett, Marc S, Rhodes, Gerry, Tohan, Sanjeev, Huggins, John W, Baker, Robert O, Kern, Earl R, Keith, Kathy A, Dai, Dongcheng, Yang, Guang, Hruby, Dennis, Jordan, Robert

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The discovery and structure–activity relationships of pyrano[3,4- b]indole-based inhibitors of hepatitis C virus NS5B polymerase by Jackson, Randy W., LaPorte, Matthew G., Herbertz, Torsten, Draper, Tandy L., Gaboury, Janet A., Rippin, Susan R., Patel, Ravi, Chunduru, Srinivas K., Benetatos, Christopher A., Young, Dorothy C., Burns, Christopher J., Condon, Stephen M.

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Electrophilic Oxidation and [1,2]-Rearrangement of the Biindole Core of Birinapant by Deng, Yijun, Haimowitz, Thomas, LaPorte, Matthew G, Rippin, Susan R, Alexander, Matthew D, Kumar, Pavan Tirunahari, Hendi, Mukta S, Lee, Yu-Hua, Condon, Stephen M

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Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models by Benetatos, Christopher A, Mitsuuchi, Yasuhiro, Burns, Jennifer M, Neiman, Eric M, Condon, Stephen M, Yu, Guangyao, Seipel, Martin E, Kapoor, Gurpreet S, Laporte, Matthew G, Rippin, Susan R, Deng, Yijun, Hendi, Mukta S, Tirunahari, Pavan K, Lee, Yu-Hua, Haimowitz, Thomas, Alexander, Matthew D, Graham, Martin A, Weng, David, Shi, Yigong, McKinlay, Mark A, Chunduru, Srinivas K

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