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Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models
by
Lhospice, F
,
Brégeon, D
,
Belmant, C
,
Dennler, P
,
Chiotellis, A
,
Fischer, E
,
Gauthier, L
,
Boëdec, A
,
Rispaud, H
,
Savard-Chambard, S
,
Represa, A
,
Schneider, N
,
Paturel, C
,
Sapet, M
,
Delcambre, C
,
Ingoure, S
,
Viaud, N
,
Bonnafous, C
,
Schibli, R
,
Romagné, F
Published in
Molecular pharmaceutics
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Journal Title
Molecular Pharmaceutics
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Subjects
Adcetris
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Animals
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Antibodies, Monoclonal - Chemistry
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Antibody Drug Conjugate
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Cd30
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Cell Line, Tumor
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Female
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Humans
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Immunoconjugates - Adverse Effects
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Immunoconjugates - Chemistry
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Immunoconjugates - Pharmacokinetics
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Life Sciences & Biomedicine
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Male
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Medicine, Research & Experimental
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Mice
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Mice, Scid
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Monomethyl Auristatin E
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Oligopeptides - Chemistry
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Pharmacology & Pharmacy
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Rats
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American Chemical Society:jisc Collections:american Chemical Society Read & Publish Agreement 2022-2024 (Reading List)
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