The mutational constraint spectrum quantified from variation in 141,456 humans by Karczewski, Konrad J., Francioli, Laurent C., Tiao, Grace, Cummings, Beryl B., Alföldi, Jessica, Wang, Qingbo, Collins, Ryan L., Laricchia, Kristen M., Ganna, Andrea, Birnbaum, Daniel P., Gauthier, Laura D., Brand, Harrison, Solomonson, Matthew, Watts, Nicholas A., Rhodes, Daniel, Singer-Berk, Moriel, England, Eleina M., Seaby, Eleanor G., Kosmicki, Jack A., Walters, Raymond K., Tashman, Katherine, Farjoun, Yossi, Banks, Eric, Poterba, Timothy, Wang, Arcturus, Seed, Cotton, Whiffin, Nicola, Chong, Jessica X., Samocha, Kaitlin E., Pierce-Hoffman, Emma, Zappala, Zachary, O’Donnell-Luria, Anne H., Minikel, Eric Vallabh, Weisburd, Ben, Lek, Monkol, Ware, James S., Vittal, Christopher, Armean, Irina M., Bergelson, Louis, Cibulskis, Kristian, Connolly, Kristen M., Covarrubias, Miguel, Donnelly, Stacey, Ferriera, Steven, Gabriel, Stacey, Gentry, Jeff, Gupta, Namrata, Jeandet, Thibault, Kaplan, Diane, Llanwarne, Christopher, Munshi, Ruchi, Novod, Sam, Petrillo, Nikelle, Roazen, David, Ruano-Rubio, Valentin, Saltzman, Andrea, Schleicher, Molly, Soto, Jose, Tibbetts, Kathleen, Tolonen, Charlotte, Wade, Gordon, Talkowski, Michael E., Neale, Benjamin M., Daly, Mark J., MacArthur, Daniel G.

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Analysis of protein-coding genetic variation in 60,706 humans by Lek, Monkol, Karczewski, Konrad J., Minikel, Eric V., Samocha, Kaitlin E., Banks, Eric, Fennell, Timothy, O’Donnell-Luria, Anne H., Ware, James S., Hill, Andrew J., Cummings, Beryl B., Tukiainen, Taru, Birnbaum, Daniel P., Kosmicki, Jack A., Duncan, Laramie E., Estrada, Karol, Zhao, Fengmei, Zou, James, Pierce-Hoffman, Emma, Berghout, Joanne, Cooper, David N., Deflaux, Nicole, DePristo, Mark, Do, Ron, Flannick, Jason, Fromer, Menachem, Gauthier, Laura, Goldstein, Jackie, Gupta, Namrata, Howrigan, Daniel, Kiezun, Adam, Kurki, Mitja I., Moonshine, Ami Levy, Natarajan, Pradeep, Orozco, Lorena, Peloso, Gina M., Poplin, Ryan, Rivas, Manuel A., Ruano-Rubio, Valentin, Rose, Samuel A., Ruderfer, Douglas M., Shakir, Khalid, Stenson, Peter D., Stevens, Christine, Thomas, Brett P., Tiao, Grace, Tusie-Luna, Maria T., Weisburd, Ben, Won, Hong-Hee, Yu, Dongmei, Altshuler, David M., Ardissino, Diego, Boehnke, Michael, Danesh, John, Donnelly, Stacey, Elosua, Roberto, Florez, Jose C., Gabriel, Stacey B., Getz, Gad, Glatt, Stephen J., Hultman, Christina M., Kathiresan, Sekar, Laakso, Markku, McCarroll, Steven, McCarthy, Mark I., McGovern, Dermot, McPherson, Ruth, Neale, Benjamin M., Palotie, Aarno, Purcell, Shaun M., Saleheen, Danish, Scharf, Jeremiah M., Sklar, Pamela, Sullivan, Patrick F., Tuomilehto, Jaakko, Tsuang, Ming T., Watkins, Hugh C., Wilson, James G., Daly, Mark J., MacArthur, Daniel G.

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Association between DNA methylation and coronary heart disease or other atherosclerotic events: A systematic review by Fernández-Sanlés, Alba, Sayols-Baixeras, Sergi, Subirana, Isaac, Degano, Irene R, Elosua, Roberto

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Validation of the Regicor Short Physical Activity Questionnaire for the Adult Population by Molina, Luis, Sarmiento, Manuel, Peñafiel, Judith, Donaire, David, Garcia-Aymerich, Judith, Gomez, Miquel, Ble, Mireia, Ruiz, Sonia, Frances, Albert, Schröder, Helmut, Marrugat, Jaume, Elosua, Roberto

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Transcript expression-aware annotation improves rare variant interpretation by Cummings, Beryl B., Karczewski, Konrad J., Kosmicki, Jack A., Seaby, Eleanor G., Watts, Nicholas A., Singer-Berk, Moriel, Mudge, Jonathan M., Karjalainen, Juha, Satterstrom, F. Kyle, O’Donnell-Luria, Anne H., Poterba, Timothy, Seed, Cotton, Solomonson, Matthew, Alföldi, Jessica, Daly, Mark J., MacArthur, Daniel G.

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A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease by Emdin, Connor A, Haas, Mary E, Khera, Amit V, Aragam, Krishna, Chaffin, Mark, Klarin, Derek, Hindy, George, Jiang, Lan, Wei, Wei-Qi, Feng, Qiping, Karjalainen, Juha, Havulinna, Aki, Kiiskinen, Tuomo, Bick, Alexander, Ardissino, Diego, Wilson, James G, Schunkert, Heribert, McPherson, Ruth, Watkins, Hugh, Elosua, Roberto, Bown, Matthew J, Samani, Nilesh J, Baber, Usman, Erdmann, Jeanette, Gupta, Namrata, Danesh, John, Saleheen, Danish, Chang, Kyong-Mi, Vujkovic, Marijana, Voight, Ben, Damrauer, Scott, Lynch, Julie, Kaplan, David, Serper, Marina, Tsao, Philip, Mercader, Josep, Hanis, Craig, Daly, Mark, Denny, Joshua, Gabriel, Stacey, Kathiresan, Sekar

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Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels by Emdin, Connor A., DPhil, Khera, Amit V., MD, Natarajan, Pradeep, MD, Klarin, Derek, MD, Won, Hong-Hee, PhD, Peloso, Gina M., PhD, Stitziel, Nathan O., MD, PhD, Nomura, Akihiro, MD, Zekavat, Seyedeh M., BSc, Bick, Alexander G., MD, Gupta, Namrata, PhD, Asselta, Rosanna, PhD, Duga, Stefano, PhD, Merlini, Piera Angelica, MD, Correa, Adolfo, MD, Kessler, Thorsten, MD, Wilson, James G., MD, Bown, Matthew J., MD, Hall, Alistair S., MD, Braund, Peter S., PhD, Samani, Nilesh J., MD, Schunkert, Heribert, MD, Marrugat, Jaume, MD, PhD, Elosua, Roberto, MD, PhD, McPherson, Ruth, MD, Farrall, Martin, PhD, Watkins, Hugh, MD, PhD, Willer, Cristen, PhD, Abecasis, Gonçalo R., PhD, Felix, Janine F., MD, PhD, Vasan, Ramachandran S., MD, Lander, Eric, PhD, Rader, Daniel J., MD, Danesh, John, MSc, DPhil, Ardissino, Diego, MD, Gabriel, Stacey, PhD, Saleheen, Danish, MD, Kathiresan, Sekar, MD

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Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage by Woo, Daniel, Falcone, Guido J., Devan, William J., Brown, W. Mark, Biffi, Alessandro, Howard, Timothy D., Anderson, Christopher D., Brouwers, H. Bart, Valant, Valerie, Battey, Thomas W.K., Radmanesh, Farid, Raffeld, Miriam R., Baedorf-Kassis, Sylvia, Deka, Ranjan, Woo, Jessica G., Martin, Lisa J., Haverbusch, Mary, Moomaw, Charles J., Sun, Guangyun, Broderick, Joseph P., Flaherty, Matthew L., Martini, Sharyl R., Kleindorfer, Dawn O., Kissela, Brett, Comeau, Mary E., Jagiella, Jeremiasz M., Schmidt, Helena, Freudenberger, Paul, Pichler, Alexander, Enzinger, Christian, Hansen, Björn M., Norrving, Bo, Jimenez-Conde, Jordi, Giralt-Steinhauer, Eva, Elosua, Roberto, Cuadrado-Godia, Elisa, Soriano, Carolina, Roquer, Jaume, Kraft, Peter, Ayres, Alison M., Schwab, Kristin, McCauley, Jacob L., Pera, Joanna, Urbanik, Andrzej, Rost, Natalia S., Goldstein, Joshua N., Viswanathan, Anand, Stögerer, Eva-Maria, Tirschwell, David L., Selim, Magdy, Brown, Devin L., Silliman, Scott L., Worrall, Bradford B., Meschia, James F., Kidwell, Chelsea S., Montaner, Joan, Fernandez-Cadenas, Israel, Delgado, Pilar, Malik, Rainer, Dichgans, Martin, Greenberg, Steven M., Rothwell, Peter M., Lindgren, Arne, Slowik, Agnieszka, Schmidt, Reinhold, Langefeld, Carl D., Rosand, Jonathan

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DNA methylation and obesity traits: An epigenome-wide association study. The REGICOR study by Sayols-Baixeras, Sergi, Subirana, Isaac, Fernández-Sanlés, Alba, Sentí, Mariano, Lluís-Ganella, Carla, Marrugat, Jaume, Elosua, Roberto

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Association between long-term air pollution exposure and DNA methylation: The REGICOR study by Sayols-Baixeras, Sergi, Fernández-Sanlés, Alba, Prats-Uribe, Albert, Subirana, Isaac, Plusquin, Michelle, Künzli, Nino, Marrugat, Jaume, Basagaña, Xavier, Elosua, Roberto

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Do individuals with autoimmune disease have increased risk of subclinical carotid atherosclerosis and stiffness? by Vila, Maria Del Mar, Remeseiro, Beatriz, Igual, Laura, Elosua, Roberto, Ramos, Rafel, Valdivielso, Jose Manuel, Martí-Lluch, Ruth, Marrugat, Jaume, Grau, Maria

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Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGT M235T) polymorphisms with the risk of obesity in a Tunisian population by Khamlaoui, Wided, Mehri, Sounira, Hammami, Sonia, Elosua, Roberto, Hammami, Mohamed

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Effect of the number of measurement sites on land use regression models in estimating local air pollution by Basagaña, Xavier, Rivera, Marcela, Aguilera, Inmaculada, Agis, David, Bouso, Laura, Elosua, Roberto, Foraster, Maria, de Nazelle, Audrey, Nieuwenhuijsen, Mark, Vila, Joan, Künzli, Nino

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Statins for Prevention of Cardiovascular Events in a Low-Risk Population With Low Ankle Brachial Index by Ramos, Rafel, MD, PhD, García-Gil, Maria, MD, PhD, Comas-Cufí, Marc, MSc, Quesada, Miquel, MD, Marrugat, Jaume, MD, PhD, Elosua, Roberto, MD, PhD, Sala, Joan, MD, PhD, Grau, María, MD, PhD, Martí, Ruth, PhD, Ponjoan, Anna, MPh, Alves-Cabratosa, Lia, MD, Blanch, Jordi, MSc, Bolíbar, Bonaventura, MD

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Association Between Genetic Variants in FADS1-FADS2 and ELOVL2 and Obesity, Lipid Traits, and Fatty Acids in Tunisian Population by Khamlaoui, Wided, Mehri, Sounira, Hammami, Sonia, Hammouda, Souha, Chraeif, Imed, Elosua, Roberto, Hammami, Mohamed

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Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants by Sayols-Baixeras, Sergi, Lluís-Ganella, Carla, Lucas, Gavin, Elosua, Roberto

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Role of HDL function and LDL atherogenicity on cardiovascular risk: A comprehensive examination by Hernáez, Álvaro, Soria-Florido, María Trinidad, Schröder, Helmut, Ros, Emilio, Pintó, Xavier, Estruch, Ramón, Salas-Salvadó, Jordi, Corella, Dolores, Arós, Fernando, Serra-Majem, Lluis, Martínez-González, Miguel Ángel, Fiol, Miquel, Lapetra, José, Elosua, Roberto, Lamuela-Raventós, Rosa María, Fitó, Montserrat

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Long-term endurance sport practice increases the incidence of lone atrial fibrillation in men: a follow-up study by Molina, Lluis, Mont, Lluis, Marrugat, Jaume, Berruezo, Antonio, Brugada, Josep, Bruguera, Jordi, Rebato, Carolina, Elosua, Roberto

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Combined use of high-sensitivity ST2 and NTproBNP to improve the prediction of death in heart failure by Bayes-Genis, Antoni, de Antonio, Marta, Galán, Amparo, Sanz, Héctor, Urrutia, Agustin, Cabanes, Roser, Cano, Lucía, González, Beatriz, Díez, Cristanto, Pascual, Teresa, Elosúa, Roberto, Lupón, Josep

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Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease by Emdin, Connor A., Khera, Amit V., Chaffin, Mark, Klarin, Derek, Natarajan, Pradeep, Aragam, Krishna, Haas, Mary, Bick, Alexander, Zekavat, Seyedeh M., Nomura, Akihiro, Ardissino, Diego, Wilson, James G., Schunkert, Heribert, McPherson, Ruth, Watkins, Hugh, Elosua, Roberto, Bown, Matthew J., Samani, Nilesh J., Baber, Usman, Erdmann, Jeanette, Gupta, Namrata, Danesh, John, Chasman, Daniel, Ridker, Paul, Denny, Joshua, Bastarache, Lisa, Lichtman, Judith H., D’Onofrio, Gail, Mattera, Jennifer, Spertus, John A., Sheu, Wayne H.-H., Taylor, Kent D., Psaty, Bruce M., Rich, Stephen S., Post, Wendy, Rotter, Jerome I., Chen, Yii-Der Ida, Krumholz, Harlan, Saleheen, Danish, Gabriel, Stacey, Kathiresan, Sekar

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