Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development by Page, Natalie, Wappett, Mark, O’Dowd, Colin R., O’Rourke, Martin, Gavory, Gerald, Zhang, Lixin, Rountree, J. S. Shane, Jordan, Linda, Barker, Oliver, Gibson, Hayley, Boyd, Caroline, Feutren-Burton, Stephanie, McLean, Estelle, Trevitt, Graham, Harrison, Timothy

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USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF by Jurisic, Anamarija, Sung, Pei‐Ju, Wappett, Mark, Daubriac, Julien, Lobb, Ian T., Kung, Wei‐Wei, Crawford, Nyree, Page, Natalie, Cassidy, Eamon, Feutren‐Burton, Stephanie, Rountree, J. S. Shane, Helm, Matthew D., O'Dowd, Colin R., Kennedy, Richard D., Gavory, Gerald, Cranston, Aaron N., Longley, Daniel B., Jacq, Xavier, Harrison, Timothy

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Lysosomal storage of oligosaccharide and glycosphingolipid in imino sugar treated cells by Boomkamp, Stephanie D, Rountree, J. S. Shane, Neville, David C. A, Dwek, Raymond A, Fleet, George W. J, Butters, Terry D

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Synthesis of a Novel Polyhydroxylated Salicylic Acid Lactone Framework by Rountree, J. S. Shane, Murphy, Paul V

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Design, Synthesis, and Biological Evaluation of Enantiomeric β-N-Acetylhexosaminidase Inhibitors LABNAc and DABNAc as Potential Agents against Tay-Sachs and Sandhoff Disease by Rountree, J. S. Shane, Butters, Terry D., Wormald, Mark R., Boomkamp, Stephanie D., Dwek, Raymond A., Asano, Naoki, Ikeda, Kyoko, Evinson, Emma L., Nash, Robert J., Fleet, George W. J.

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Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors by O’Dowd, Colin R, Helm, Matthew D, Rountree, J. S. Shane, Flasz, Jakub T, Arkoudis, Elias, Miel, Hugues, Hewitt, Peter R, Jordan, Linda, Barker, Oliver, Hughes, Caroline, Rozycka, Ewelina, Cassidy, Eamon, McClelland, Keeva, Odrzywol, Ewa, Page, Natalie, Feutren-Burton, Stephanie, Dvorkin, Scarlett, Gavory, Gerald, Harrison, Timothy

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Synthesis and Biological Characterisation of Novel N-Alkyl-Deoxynojirimycin α-Glucosidase Inhibitors by Rawlings, Amy J, Lomas, Hannah, Pilling, Adam W, Lee, Marvin J.-R, Alonzi, Dominic S, Rountree, J.S. Shane, Jenkinson, Sarah F, Fleet, George W.J, Dwek, Raymond A, Jones, John H, Butters, Terry D

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Abstract LB022: A novel first-in-class USP19 inhibitor for the treatment of cancer-induced muscle atrophy by Page, Natalie, Karthikaisamy, Vignesh, O'Hara, Darren, Cranston, Aaron N., O'Dowd, Colin R., Jacq, Xavier, Wilkinson, Richard, Burton, Stephanie, Gibson, Hayley, Costa, Joana, Longley, Daniel, Helm, Matthew, McGivern, Chris, Shepherd, Steven, Bell, Christina, Hewitt, Peter, McFarland, Mary, Miel, Hugues, Whitehead, Steven, Proctor, Lauren, Rountree, Shane J., Wappett, Mark, Diaz, Mauricio Berriel, Herzig, Stephan, Harrison, Timothy

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Synthesis and Biological Characterisation of Novel N-Alkyl-Deoxynojirimycin a-Glucosidase Inhibitors by Rawlings, Amy J, Lomas, Hannah, Pilling, Adam W, Lee, Marvin J-R, Alonzi, Dominic S, Rountree, J S Shane, Jenkinson, Sarah F, Fleet, George W J, Dwek, Raymond A, Jones, John H, Butters, Terry D

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Efficient synthesis from d-lyxonolactone of 2-acetamido-1,4-imino-1,2,4-trideoxy- l-arabinitol LABNAc, a potent pyrrolidine inhibitor of hexosaminidases by Rountree, J.S.Shane, Butters, Terry D., Wormald, Mark R., Dwek, Raymond A., Asano, Naoki, Ikeda, Kyoko, Evinson, Emma L., Nash, Robert J., Fleet, George W.J.

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