Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays by MANFREDI, Mark G, ECSEDY, Jeffrey A, WYSONG, Deborah R, JANOWICK, David A, HYER, Marc L, LEROY, Patrick J, GERSHMAN, Rachel E, SILVA, Matthew D, GERMANOS, Melissa S, BOLEN, Joseph B, CLAIBORNE, Christopher F, SELLS, Todd B, CHAKRAVARTY, Arijit, SILVERMAN, Lee, MENGKUN ZHANG, HOAR, Kara M, STROUD, Stephen G, WEI CHEN, SHINDE, Vaishali, HUCK, Jessica J

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Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ by Brownell, James E., Sintchak, Michael D., Gavin, James M., Liao, Hua, Bruzzese, Frank J., Bump, Nancy J., Soucy, Teresa A., Milhollen, Michael A., Yang, Xiaofeng, Burkhardt, Anne L., Ma, Jingya, Loke, Huay-Keng, Lingaraj, Trupti, Wu, Dongyun, Hamman, Kristin B., Spelman, James J., Cullis, Courtney A., Langston, Steven P., Vyskocil, Stepan, Sells, Todd B., Mallender, William D., Visiers, Irache, Li, Ping, Claiborne, Christopher F., Rolfe, Mark, Bolen, Joseph B., Dick, Lawrence R.

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Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase by Manfredi, Mark G, Ecsedy, Jeffrey A, Meetze, Kristan A, Balani, Suresh K, Burenkova, Olga, Chen, Wei, Galvin, Katherine M, Hoar, Kara M, Huck, Jessica J, LeRoy, Patrick J, Ray, Emily T, Sells, Todd B, Stringer, Bradley, Stroud, Stephen G, Vos, Tricia J, Weatherhead, Gabriel S, Wysong, Deborah R, Zhang, Mengkun, Bolen, Joseph B, Claiborne, Christopher F

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Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 by Milhollen, Michael A., Thomas, Michael P., Narayanan, Usha, Traore, Tary, Riceberg, Jessica, Amidon, Benjamin S., Bence, Neil F., Bolen, Joseph B., Brownell, James, Dick, Lawrence R., Loke, Huay-Keng, McDonald, Alice A., Ma, Jingya, Manfredi, Mark G., Sells, Todd B., Sintchak, Mike D., Yang, Xiaofeng, Xu, Qing, Koenig, Erik M., Gavin, James M., Smith, Peter G.

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MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors by Sells, Todd B., Chau, Ryan, Ecsedy, Jeffrey A., Gershman, Rachel E., Hoar, Kara, Huck, Jessica, Janowick, David A., Kadambi, Vivek J., LeRoy, Patrick J., Stirling, Matthew, Stroud, Stephen G., Vos, Tricia J., Weatherhead, Gabriel S., Wysong, Deborah R., Zhang, Mengkun, Balani, Suresh K., Bolen, Joseph B., Manfredi, Mark G., Claiborne, Christopher F.

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Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905) by Duffey, Matthew O, Vos, Tricia J, Adams, Ruth, Alley, Jennifer, Anthony, Justin, Barrett, Cynthia, Bharathan, Indu, Bowman, Douglas, Bump, Nancy J, Chau, Ryan, Cullis, Courtney, Driscoll, Denise L, Elder, Amy, Forsyth, Nancy, Frazer, Jonathan, Guo, Jianping, Guo, Luyi, Hyer, Marc L, Janowick, David, Kulkarni, Bheemashankar, Lai, Su-Jen, Lasky, Kerri, Li, Gang, Li, Jing, Liao, Debra, Little, Jeremy, Peng, Bo, Qian, Mark G, Reynolds, Dominic J, Rezaei, Mansoureh, Scott, Margaret Porter, Sells, Todd B, Shinde, Vaishali, Shi, Qiuju Judy, Sintchak, Michael D, Soucy, Francois, Sprott, Kevin T, Stroud, Stephen G, Nestor, Michelle, Visiers, Irache, Weatherhead, Gabriel, Ye, Yingchun, D’Amore, Natalie

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Synthesis of congeners of adenosine resistant to deamination by adenosine deaminase by VASU NAIR, PURDY, D. F, SELLS, T. B

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Enzymatic Synthesis of 2′,3′-Dideoxyguanosine by Nair, Vasu, Sells, Todd B.

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Enzymatic Synthesis of 2′,3′-Dideoxyguanosine by Nair, Vasu, Sells, Todd B.

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Discovery and Characterization of Aminopiperidinecoumarin Melanin Concentrating Hormone Receptor 1 Antagonists by Kym, Philip R, Iyengar, Rajesh, Souers, Andrew J, Lynch, John K, Judd, Andrew S, Gao, Ju, Freeman, Jennifer, Mulhern, Mathew, Zhao, Gang, Vasudevan, Anil, Wodka, Dariusz, Blackburn, Christopher, Brown, Jim, Che, Jennifer Lee, Cullis, Courtney, Lai, Su Jen, LaMarche, Matthew J, Marsilje, Tom, Roses, Jon, Sells, Todd, Geddes, Brad, Govek, Elizabeth, Patane, Michael, Fry, Dennis, Dayton, Brian D, Brodjian, Sevan, Falls, Doug, Brune, Michael, Bush, Eugene, Shapiro, Robin, Knourek-Segel, Victoria, Fey, Thomas, McDowell, Cathleen, Reinhart, Glenn A, Preusser, Lee C, Marsh, Kennan, Hernandez, Lisa, Sham, Hing L, Collins, Christine A

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Efficacy and Safety of Pyridoxal 5′-Phosphate (MC-1) in High-Risk Patients Undergoing Coronary Artery Bypass Graft Surgery: The MEND-CABG II Randomized Clinical Trial by Alexander, John H, Emery, Jr, Robert W, Carrier, Michel, Ellis, Stephen J, Mehta, Rajendra H, Hasselblad, Vic, Menasche, Philippe, Khalil, Ahmad, Cote, Robert, Bennett-Guerrero, Elliott, Mack, Michael J, Schuler, Gerhard, Harrington, Robert A, Tardif, Jean-Claude

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