PDE10A Inhibitors-Clinical Failure or Window Into Antipsychotic Drug Action? by Menniti, Frank S, Chappie, Thomas A, Schmidt, Christopher J

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Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy by Verhoest, Patrick R, Proulx-Lafrance, Caroline, Corman, Michael, Chenard, Lois, Helal, Christopher J, Hou, Xinjun, Kleiman, Robin, Liu, Shenping, Marr, Eric, Menniti, Frank S, Schmidt, Christopher J, Vanase-Frawley, Michelle, Schmidt, Anne W, Williams, Robert D, Nelson, Frederick R, Fonseca, Kari R, Liras, Spiros

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Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy by Diggle, Christine P., Sukoff Rizzo, Stacey J., Popiolek, Michael, Hinttala, Reetta, Schülke, Jan-Philip, Kurian, Manju A., Carr, Ian M., Markham, Alexander F., Bonthron, David T., Watson, Christopher, Sharif, Saghira Malik, Reinhart, Veronica, James, Larry C., Vanase-Frawley, Michelle A., Charych, Erik, Allen, Melanie, Harms, John, Schmidt, Christopher J., Ng, Joanne, Pysden, Karen, Strick, Christine, Vieira, Päivi, Mankinen, Katariina, Kokkonen, Hannaleena, Kallioinen, Matti, Sormunen, Raija, Rinne, Juha O., Johansson, Jarkko, Alakurtti, Kati, Huilaja, Laura, Hurskainen, Tiina, Tasanen, Kaisa, Anttila, Eija, Marques, Tiago Reis, Howes, Oliver, Politis, Marius, Fahiminiya, Somayyeh, Nguyen, Khanh Q., Majewski, Jacek, Uusimaa, Johanna, Sheridan, Eamonn, Brandon, Nicholas J.

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Inhibition of Phosphodiesterase 10A Increases the Responsiveness of Striatal Projection Neurons to Cortical Stimulation by Threlfell, Sarah, Sammut, Stephen, Menniti, Frank S, Schmidt, Christopher J, West, Anthony R

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Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pa... by Padovan-Neto, Fernando E, Sammut, Stephen, Chakroborty, Shreaya, Dec, Alexander M, Threlfell, Sarah, Campbell, Peter W, Mudrakola, Vishnu, Harms, John F, Schmidt, Christopher J, West, Anthony R

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Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor by Helal, Christopher J, Arnold, Eric P, Boyden, Tracey L, Chang, Cheng, Chappie, Thomas A, Fennell, Kimberly F, Forman, Michael D, Hajos, Mihaly, Harms, John F, Hoffman, William E, Humphrey, John M, Kang, Zhijun, Kleiman, Robin J, Kormos, Bethany L, Lee, Che-Wah, Lu, Jiemin, Maklad, Noha, McDowell, Laura, Mente, Scot, O’Connor, Rebecca E, Pandit, Jayvardhan, Piotrowski, Mary, Schmidt, Anne W, Schmidt, Christopher J, Ueno, Hirokazu, Verhoest, Patrick R, Yang, Edward X

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Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo by Kleiman, Robin J, Chapin, Douglas S, Christoffersen, Curt, Freeman, Jody, Fonseca, Kari R, Geoghegan, Kieran F, Grimwood, Sarah, Guanowsky, Victor, Hajós, Mihály, Harms, John F, Helal, Christopher J, Hoffmann, William E, Kocan, Geralyn P, Majchrzak, Mark J, McGinnis, Dina, McLean, Stafford, Menniti, Frank S, Nelson, Fredrick, Roof, Robin, Schmidt, Anne W, Seymour, Patricia A, Stephenson, Diane T, Tingley, Francis David, Vanase-Frawley, Michelle, Verhoest, Patrick R, Schmidt, Christopher J

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Inhibition of the striatum-enriched phosphodiesterase PDE10A: A novel approach to the treatment of psychosis by Siuciak, Judith A., Chapin, Douglas S., Harms, John F., Lebel, Lorraine A., McCarthy, Sheryl A., Chambers, Leslie, Shrikhande, Alka, Wong, Stephen, Menniti, Frank S., Schmidt, Christopher J.

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Chronic suppression of phosphodiesterase 10A alters striatal expression of genes responsible for neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in... by Kleiman, Robin J, Kimmel, Lida H, Bove, Susan E, Lanz, Thomas A, Harms, John F, Romegialli, Alison, Miller, Kenneth S, Willis, Amy, des Etages, Shelley, Kuhn, Max, Schmidt, Christopher J

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Immunohistochemical Localization of Phosphodiesterase 10A in Multiple Mammalian Species by Coskran, Timothy M, Morton, Daniel, Menniti, Frank S, Adamowicz, Wendy O, Kleiman, Robin J, Ryan, Anne M, Strick, Christine A, Schmidt, Christopher J, Stephenson, Diane T

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Inhibition of phosphodiesterase 10A has differential effects on dopamine D1 and D2 receptor modulation of sensorimotor gating by Gresack, Jodi E., Seymour, Patricia A., Schmidt, Christopher J., Risbrough, Victoria B.

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Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: Evidence for altered striatal function by Siuciak, Judith A., McCarthy, Sheryl A., Chapin, Douglas S., Fujiwara, Remie A., James, Larry C., Williams, Robert D., Stock, Jeffrey L., McNeish, John D., Strick, Christine A., Menniti, Frank S., Schmidt, Christopher J.

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Positive Allosteric Modulation of AMPA Receptors from Efficacy to Toxicity: The Interspecies Exposure-Response Continuum of the Novel Potentiator PF-4778574 by Shaffer, Christopher L., Hurst, Raymond S., Scialis, Renato J., Osgood, Sarah M., Bryce, Dianne K., Hoffmann, William E., Lazzaro, John T., Hanks, Ashley N., Lotarski, Susan, Weber, Mark L., Liu, JianHua, Menniti, Frank S., Schmidt, Christopher J., Hajós, Mihály

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Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels by Martina, Marzia, Gorfinkel, Yelena, Halman, Samantha, Lowe, John A., Periyalwar, Pranav, Schmidt, Christopher J., Bergeron, Richard

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Immunohistochemical localization of PDE10A in the rat brain by Seeger, Thomas F, Bartlett, Brenda, Coskran, Timothy M, Culp, Jeffrey S, James, Larry C, Krull, David L, Lanfear, Jerry, Ryan, Anne M, Schmidt, Christopher J, Strick, Christine A, Varghese, Alison H, Williams, Robert D, Wylie, Patricia G, Menniti, Frank S

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Discovery of a Series of 6,7-Dimethoxy-4-pyrrolidylquinazoline PDE10A Inhibitors by Chappie, Thomas A., Humphrey, John M., Allen, Martin P., Estep, Kimberly G., Fox, Carol B., Lebel, Lorraine A., Liras, Spiros, Marr, Eric S., Menniti, Frank S., Pandit, Jayvardhan, Schmidt, Christopher J., Tu, Meihua, Williams, Robert D., Yang, Feng V.

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Development and validation of a sample stabilization strategy and a UPLC–MS/MS method for the simultaneous quantitation of acetylcholine (ACh), histamine (HA), and its metabolites... by Zhang, Yanhua, Tingley, F. David, Tseng, Elaine, Tella, Max, Yang, Xin, Groeber, Elizabeth, Liu, Jianhua, Li, Wenlin, Schmidt, Christopher J., Steenwyk, Rick

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Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide by Harms, John F, Menniti, Frank S, Schmidt, Christopher J

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Alterations in gene regulation following inhibition of the striatum-enriched phosphodiesterase, PDE10A by Strick, Christine A., James, Larry C., Fox, Carol B., Seeger, Thomas F., Menniti, Frank S., Schmidt, Christopher J.

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Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction by Roberts, Brooke M., Holden, Daniel E., Shaffer, Christopher L., Seymour, Patricia A., Menniti, Frank S., Schmidt, Christopher J., Williams, Graham V., Castner, Stacy A.

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