Search Results - Schofield Christopher J.

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  1. 21
    Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains

    Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains by Hay, Duncan A, Fedorov, Oleg, Martin, Sarah, Singleton, Dean C, Tallant, Cynthia, Wells, Christopher, Picaud, Sarah, Philpott, Martin, Monteiro, Octovia P, Rogers, Catherine M, Conway, Stuart J, Rooney, Timothy P. C, Tumber, Anthony, Yapp, Clarence, Filippakopoulos, Panagis, Bunnage, Mark E, Müller, Susanne, Knapp, Stefan, Schofield, Christopher J, Brennan, Paul E

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  2. 22
    Inhibition of 2-oxoglutarate dependent oxygenases

    Inhibition of 2-oxoglutarate dependent oxygenases by Rose, Nathan R, McDonough, Michael A, King, Oliver N F, Kawamura, Akane, Schofield, Christopher J

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  3. 23
    Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

    Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases by Chowdhury, Rasheduzzaman, Leung, Ivanhoe K. H., Tian, Ya-Min, Abboud, Martine I., Ge, Wei, Domene, Carmen, Cantrelle, François-Xavier, Landrieu, Isabelle, Hardy, Adam P., Pugh, Christopher W., Ratcliffe, Peter J., Claridge, Timothy D. W., Schofield, Christopher J.

    Published in Nature communications
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  4. 24
    Catalysis by the Non-Heme Iron(II) Histone Demethylase PHF8 Involves Iron Center Rearrangement and Conformational Modulation of Substrate Orientation

    Catalysis by the Non-Heme Iron(II) Histone Demethylase PHF8 Involves Iron Center Rearrangement and Conformational Modulation of Substrate Orientation by Chaturvedi, Shobhit S, Ramanan, Rajeev, Lehnert, Nicolai, Schofield, Christopher J, Karabencheva-Christova, Tatyana G, Christov, Christo Z

    Published in ACS catalysis
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  5. 25
    DNA Modification under Mild Conditions by Suzuki-Miyaura Cross-Coupling for the Generation of Functional Probes

    DNA Modification under Mild Conditions by Suzuki-Miyaura Cross-Coupling for the Generation of Functional Probes by Lercher, Lukas, McGouran, Joanna F., Kessler, Benedikt M., Schofield, Christopher J., Davis, Benjamin G.

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  6. 26
    Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5

    Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5 by Islam, Md. Saiful, Markoulides, Marios, Chowdhury, Rasheduzzaman, Schofield, Christopher J.

    Published in Scientific reports
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  7. 27
    Improved Synthesis of Phosphoramidite-Protected N6-Methyladenosine via BOP-Mediated SNAr Reaction

    Improved Synthesis of Phosphoramidite-Protected N6-Methyladenosine via BOP-Mediated SNAr Reaction by Shishodia, Shifali, Schofield, Christopher J.

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  8. 28
    Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors

    Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors by King, Oliver N F, Li, Xuan Shirley, Sakurai, Masaaki, Kawamura, Akane, Rose, Nathan R, Ng, Stanley S, Quinn, Amy M, Rai, Ganesha, Mott, Bryan T, Beswick, Paul, Klose, Robert J, Oppermann, Udo, Jadhav, Ajit, Heightman, Tom D, Maloney, David J, Schofield, Christopher J, Simeonov, Anton

    Published in PloS one
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  9. 29
    A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene

    A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene by Church, Chris, Lee, Sheena, Bagg, Eleanor A L, McTaggart, James S, Deacon, Robert, Gerken, Thomas, Lee, Angela, Moir, Lee, Mecinović, Jasmin, Quwailid, Mohamed M, Schofield, Christopher J, Ashcroft, Frances M, Cox, Roger D

    Published in PLoS genetics
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  10. 30
    A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway

    A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway by Lu, Min, Zak, Jaroslav, Chen, Shuo, Sanchez-Pulido, Luis, Severson, David T., Endicott, Jane, Ponting, Chris P., Schofield, Christopher J., Lu, Xin

    Published in Cell
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  11. 31
    Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors

    Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors by Reinbold, Raphael, Hvinden, Ingvild C., Rabe, Patrick, Herold, Ryan A., Finch, Alina, Wood, James, Morgan, Melissa, Staudt, Maximillian, Clifton, Ian J., Armstrong, Fraser A., McCullagh, James S. O., Redmond, Jo, Bardella, Chiara, Abboud, Martine I., Schofield, Christopher J.

    Published in Nature communications
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  12. 32
    Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

    Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates by Cockman, Matthew E, Lippl, Kerstin, Tian, Ya-Min, Pegg, Hamish B, Figg, Jnr, William D, Abboud, Martine I, Heilig, Raphael, Fischer, Roman, Myllyharju, Johanna, Schofield, Christopher J, Ratcliffe, Peter J

    Published in eLife
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  13. 33
    Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

    Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition by Yosaatmadja, Yuliana, Baddock, Hannah T, Newman, Joseph A, Bielinski, Marcin, Gavard, Angeline E, Mukhopadhyay, Shubhashish M M, Dannerfjord, Adam A, Schofield, Christopher J, McHugh, Peter J, Gileadi, Opher

    Published in Nucleic acids research
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  14. 34
    An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography

    An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography by Butryn, Agata, Simon, Philipp S., Aller, Pierre, Hinchliffe, Philip, Massad, Ramzi N., Leen, Gabriel, Tooke, Catherine L., Bogacz, Isabel, Kim, In-Sik, Bhowmick, Asmit, Brewster, Aaron S., Devenish, Nicholas E., Brem, Jürgen, Kamps, Jos J. A. G., Lang, Pauline A., Rabe, Patrick, Axford, Danny, Beale, John H., Davy, Bradley, Ebrahim, Ali, Orlans, Julien, Storm, Selina L. S., Zhou, Tiankun, Owada, Shigeki, Tanaka, Rie, Tono, Kensuke, Evans, Gwyndaf, Owen, Robin L., Houle, Frances A., Sauter, Nicholas K., Schofield, Christopher J., Spencer, James, Yachandra, Vittal K., Yano, Junko, Kern, Jan F., Orville, Allen M.

    Published in Nature communications
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  15. 35
    Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library

    Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library by Shaikh, Faraz, Zhao, Yuguang, Alvarez, Luis, Iliopoulou, Maria, Lohans, Christopher, Schofield, Christopher J, Padilla-Parra, Sergi, Siu, Shirley W. I, Fry, Elizabeth E, Ren, Jingshan, Stuart, David I

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  16. 36
    Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors

    Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors by Brewitz, Lennart, Tumber, Anthony, Pfeffer, Inga, McDonough, Michael A., Schofield, Christopher J.

    Published in Scientific reports
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  17. 37
    Progress in the Development and Application of Small Molecule Inhibitors of Bromodomain–Acetyl-lysine Interactions

    Progress in the Development and Application of Small Molecule Inhibitors of Bromodomain–Acetyl-lysine Interactions by Hewings, David S, Rooney, Timothy P. C, Jennings, Laura E, Hay, Duncan A, Schofield, Christopher J, Brennan, Paul E, Knapp, Stefan, Conway, Stuart J

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  18. 38
    The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens

    The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens by Loenarz, Christoph, Coleman, Mathew L, Boleininger, Anna, Schierwater, Bernd, Holland, Peter W H, Ratcliffe, Peter J, Schofield, Christopher J

    Published in EMBO reports
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  19. 39
    A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family

    A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family by Baddock, Hannah T, Newman, Joseph A, Yosaatmadja, Yuliana, Bielinski, Marcin, Schofield, Christopher J, Gileadi, Opher, McHugh, Peter J

    Published in Nucleic acids research
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  20. 40
    Catalysis by the JmjC histone demethylase KDM4A integrates substrate dynamics, correlated motions and molecular orbital control

    Catalysis by the JmjC histone demethylase KDM4A integrates substrate dynamics, correlated motions and molecular orbital control by Ramanan, Rajeev, Chaturvedi, Shobhit S, Lehnert, Nicolai, Schofield, Christopher J, Karabencheva-Christova, Tatyana G, Christov, Christo Z

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