Symmetry breaking by enzyme-catalyzed epoxide hydrolysis by Schofield, Christopher J

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Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches by Rose, Nathan R, Woon, Esther C. Y, Kingham, Guy L, King, Oliver N. F, Mecinović, Jasmin, Clifton, Ian J, Ng, Stanley S, Talib-Hardy, Jobina, Oppermann, Udo, McDonough, Michael A, Schofield, Christopher J

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Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2 by Chowdhury, Rasheduzzaman, Abboud, Martine I., McAllister, Tom E., Banerji, Biswadip, Bhushan, Bhaskar, Sorensen, John L., Kawamura, Akane, Schofield, Christopher J.

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Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours by Snell, Cameron E, Turley, Helen, McIntyre, Alan, Li, Demin, Masiero, Massimo, Schofield, Christopher J, Gatter, Kevin C, Harris, Adrian L, Pezzella, Francesco

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Anion-exchange chromatography mass spectrometry provides extensive coverage of primary metabolic pathways revealing altered metabolism in IDH1 mutant cells by Walsby-Tickle, John, Gannon, Joan, Hvinden, Ingvild, Bardella, Chiara, Abboud, Martine I., Nazeer, Areesha, Hauton, David, Pires, Elisabete, Cadoux-Hudson, Tom, Schofield, Christopher J., McCullagh, James S. O.

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Rationally engineered flavin‐dependent oxidase reveals steric control of dioxygen reduction by Zafred, Domen, Steiner, Barbara, Teufelberger, Andrea R, Hromic, Altijana, Karplus, P. Andrew, Schofield, Christopher J, Wallner, Silvia, Macheroux, Peter

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Role of Structural Dynamics in Selectivity and Mechanism of Non-heme Fe(II) and 2‑Oxoglutarate-Dependent Oxygenases Involved in DNA Repair by Waheed, Sodiq O, Ramanan, Rajeev, Chaturvedi, Shobhit S, Lehnert, Nicolai, Schofield, Christopher J, Christov, Christo Z, Karabencheva-Christova, Tatyana G

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Phylogeography and genetic variation of Triatoma dimidiata, the main Chagas disease vector in Central America, and its position within the genus Triatoma by Bargues, María Dolores, Klisiowicz, Debora R, Gonzalez-Candelas, Fernando, Ramsey, Janine M, Monroy, Carlota, Ponce, Carlos, Salazar-Schettino, Paz María, Panzera, Francisco, Abad-Franch, Fernando, Sousa, Octavio E, Schofield, Christopher J, Dujardin, Jean Pierre, Guhl, Felipe, Mas-Coma, Santiago

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Posttranslational Hydroxylation of Ankyrin Repeats in IκB Proteins by the Hypoxia-Inducible Factor (HIF) Asparaginyl Hydroxylase, Factor Inhibiting HIF (FIH) by Cockman, Matthew E., Lancaster, David E., Stolze, Ineke P., Hewitson, Kirsty S., McDonough, Michael A., Coleman, Mathew L., Coles, Charlotte H., Yu, Xiaohong, Hay, Ronald T., Ley, Steven C., Pugh, Christopher W., Oldham, Neil J., Masson, Norma, Schofield, Christopher J., Ratcliffe, Peter J.

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Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity by NG, Stanley S, KAVANAGH, Kathryn L, ROSE, Nathan R, OFFER, John, SCHEINOST, Johanna C, BOROWSKI, Tomasz, SUNDSTROM, Michael, SCHOFIELD, Christopher J, OPPERMANN, Udo, MCDONOUGH, Michael A, BUTLER, Danica, PILKA, Ewa S, LIENARD, Benoit M. R, BRAY, James E, SAVITSKY, Pavel, GILEADI, Opher, VON DELFT, Frank

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Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases by Markolovic, Suzana, Wilkins, Sarah E., Schofield, Christopher J.

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Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family by Hewitson, Kirsty S., McNeill, Luke A., Riordan, Madeline V., Tian, Ya-Min, Bullock, Alex N., Welford, Richard W., Elkins, Jonathan M., Oldham, Neil J., Bhattacharya, Shoumo, Gleadle, Jonathan M., Ratcliffe, Peter J., Pugh, Christopher W., Schofield, Christopher J.

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Biochemical and crystallographic studies of l,d-transpeptidase 2 from Mycobacterium tuberculosis with its natural monomer substrate by de Munnik, Mariska, Lang, Pauline A., Calvopiña, Karina, Rabe, Patrick, Brem, Jürgen, Schofield, Christopher J.

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Pharmacological inhibition of FTO by McMurray, Fiona, Demetriades, Marina, Aik, WeiShen, Merkestein, Myrte, Kramer, Holger, Andrew, Daniel S, Scudamore, Cheryl L, Hough, Tertius A, Wells, Sara, Ashcroft, Frances M, McDonough, Michael A, Schofield, Christopher J, Cox, Roger D

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On the Histone Lysine Methyltransferase Activity of Fungal Metabolite Chaetocin by Cherblanc, Fanny L, Chapman, Kathryn L, Reid, Jim, Borg, Aaron J, Sundriyal, Sandeep, Alcazar-Fuoli, Laura, Bignell, Elaine, Demetriades, Marina, Schofield, Christopher J, DiMaggio, Peter A, Brown, Robert, Fuchter, Matthew J

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Mechanism of Molecular Oxygen Diffusion in a Hypoxia-Sensing Prolyl Hydroxylase Using Multiscale Simulation by Domene, Carmen, Jorgensen, Christian, Schofield, Christopher J

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Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases by Horita, Shoichiro, Scotti, John S., Thinnes, Cyrille, Mottaghi-Taromsari, Yousef S., Thalhammer, Armin, Ge, Wei, Aik, WeiShen, Loenarz, Christoph, Schofield, Christopher J., McDonough, Michael A.

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Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor by Coleman, Mathew L., McDonough, Michael A., Hewitson, Kirsty S., Coles, Charlotte, Mecinovicí, Jasmin, Edelmann, Mariola, Cook, Kristina M., Cockman, Matthew E., Lancaster, David E., Kessler, Benedikt M., Oldham, Neil J., Ratcliffe, Peter J., Schofield, Christopher J.

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Kinetic parameters of human aspartate/asparagine–β-hydroxylase suggest that it has a possible function in oxygen sensing by Brewitz, Lennart, Tumber, Anthony, Schofield, Christopher J.

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Structural and Mechanistic Studies on the Inhibition of the Hypoxia-inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates by Hewitson, Kirsty S., Liénard, Benoit M.R., McDonough, Michael A., Clifton, Ian J., Butler, Danica, Soares, Alexie S., Oldham, Neil J., McNeill, Luke A., Schofield, Christopher J.

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