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Identification of N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallog...
by
Wyatt, Paul G
,
Woodhead, Andrew J
,
Berdini, Valerio
,
Boulstridge, John A
,
Carr, Maria G
,
Cross, David M
,
Davis, Deborah J
,
Devine, Lindsay A
,
Early, Theresa R
,
Feltell, Ruth E
,
Lewis, E. Jonathan
,
McMenamin, Rachel L
,
Navarro, Eva F
,
O’Brien, Michael A
,
O’Reilly, Marc
,
Reule, Matthias
,
Saxty, Gordon
,
Seavers, Lisa C. A
,
Smith, Donna-Michelle
,
Squires, Matt S
,
Trewartha, Gary
,
Walker, Margaret T
,
Woolford, Alison J.-A
Published in
Journal of medicinal chemistry
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Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors
by
Howard, Nigel
,
Abell, Chris
,
Blakemore, Wendy
,
Chessari, Gianni
,
Congreve, Miles
,
Howard, Steven
,
Jhoti, Harren
,
Murray, Christopher W
,
Seavers, Lisa C. A
,
van Montfort, Rob L. M
Published in
Journal of medicinal chemistry
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Identification of Novel p38α MAP Kinase Inhibitors Using Fragment-Based Lead Generation
by
Gill, Adrian L
,
Frederickson, Martyn
,
Cleasby, Anne
,
Woodhead, Steven J
,
Carr, Maria G
,
Woodhead, Andrew J
,
Walker, Margaret T
,
Congreve, Miles S
,
Devine, Lindsay A
,
Tisi, Dominic
,
O'Reilly, Marc
,
Seavers, Lisa C. A
,
Davis, Deborah J
,
Curry, Jayne
,
Anthony, Rachel
,
Padova, Alessandro
,
Murray, Christopher W
,
Carr, Robin A. E
,
Jhoti, Harren
Published in
Journal of medicinal chemistry
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Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B
by
Collins, Ian
,
Caldwell, John
,
Fonseca, Tatiana
,
Donald, Alastair
,
Bavetsias, Vassilios
,
Hunter, Lisa-Jane K.
,
Garrett, Michelle D.
,
Rowlands, Martin G.
,
Aherne, G. Wynne
,
Davies, Thomas G.
,
Berdini, Valerio
,
Woodhead, Steven J.
,
Davis, Deborah
,
Seavers, Lisa C.A.
,
Wyatt, Paul G.
,
Workman, Paul
,
McDonald, Edward
Published in
Bioorganic & medicinal chemistry
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AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth
by
Grimshaw, Kyla M
,
Hunter, Lisa-Jane K
,
Yap, Timothy A
,
Heaton, Simon P
,
Walton, Mike I
,
Woodhead, Steven J
,
Fazal, Lynsey
,
Reule, Matthias
,
Davies, Thomas G
,
Seavers, Lisa C
,
Lock, Victoria
,
Lyons, John F
,
Thompson, Neil T
,
Workman, Paul
,
Garrett, Michelle D
Published in
Molecular cancer therapeutics
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Discovery of 4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)
by
McHardy, Tatiana
,
Caldwell, John J
,
Cheung, Kwai-Ming
,
Hunter, Lisa J
,
Taylor, Kevin
,
Rowlands, Martin
,
Ruddle, Ruth
,
Henley, Alan
,
de Haven Brandon, Alexis
,
Valenti, Melanie
,
Davies, Thomas G
,
Fazal, Lynsey
,
Seavers, Lisa
,
Raynaud, Florence I
,
Eccles, Suzanne A
,
Aherne, G. Wynne
,
Garrett, Michelle D
,
Collins, Ian
Published in
Journal of medicinal chemistry
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Identification of N -(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1 H -pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystal...
by
Wyatt, Paul G.
,
Woodhead, Andrew J.
,
Berdini, Valerio
,
Boulstridge, John A.
,
Carr, Maria G.
,
Cross, David M.
,
Davis, Deborah J.
,
Devine, Lindsay A.
,
Early, Theresa R.
,
Feltell, Ruth E.
,
Lewis, E. Jonathan
,
McMenamin, Rachel L.
,
Navarro, Eva F.
,
O’Brien, Michael A.
,
O’Reilly, Marc
,
Reule, Matthias
,
Saxty, Gordon
,
Seavers, Lisa C. A.
,
Smith, Donna-Michelle
,
Squires, Matt S.
,
Trewartha, Gary
,
Walker, Margaret T.
,
Woolford, Alison J.-A.
Published in
Journal of medicinal chemistry
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Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation
by
Gill, Adrian L
,
Frederickson, Martyn
,
Cleasby, Anne
,
Woodhead, Steven J
,
Carr, Maria G
,
Woodhead, Andrew J
,
Walker, Margaret T
,
Congreve, Miles S
,
Devine, Lindsay A
,
Tisi, Dominic
,
O'Reilly, Marc
,
Seavers, Lisa C A
,
Davis, Deborah J
,
Curry, Jayne
,
Anthony, Rachel
,
Padova, Alessandro
,
Murray, Christopher W
,
Carr, Robin A E
,
Jhoti, Harren
Published in
Journal of medicinal chemistry
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Vital Signs: Update on Zika Virus–Associated Birth Defects and Evaluation of All U.S. Infants with Congenital Zika Virus Exposure — U.S. Zika Pregnancy Registry, 2016
by
Reynolds, Megan R.
,
Jones, Abbey M.
,
Petersen, Emily E.
,
Lee, Ellen H.
,
Rice, Marion E.
,
Bingham, Andrea
,
Ellington, Sascha R.
,
Evert, Nicole
,
Reagan-Steiner, Sarah
,
Oduyebo, Titilope
,
Brown, Catherine M.
,
Martin, Stacey
,
Ahmad, Nina
,
Bhatnagar, Julu
,
Macdonald, Jennifer
,
Gould, Carolyn
,
Fine, Anne D.
,
Polen, Kara D.
,
Lake-Burger, Heather
,
Hillard, Christina L.
,
Hall, Noemi
,
Yazdy, Mahsa M.
,
Slaughter, Karnesha
,
Sommer, Jamie N.
,
Adamski, Alys
,
Raycraft, Meghan
,
Fleck-Derderian, Shannon
,
Gupta, Jyoti
,
Newsome, Kimberly
,
Baez-Santiago, Madelyn
,
Slavinski, Sally
,
White, Jennifer L.
,
Moore, Cynthia A.
,
Shapiro-Mendoza, Carrie K.
,
Petersen, Lyle
,
Boyle, Coleen
,
Jamieson, Denise J.
,
Meaney-Delman, Dana
,
Honein, Margaret A.
Published in
MMWR. Morbidity and mortality weekly report
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U.S. Steel Homestead Works, Along Monongahela River, north of Eighth Avenue, Homestead, Allegheny County, PA
by
Historic American Engineering Record
,
Lowe, Jet
,
Stupich, Martin
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