Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors by Burnett, G. Leslie, Yang, Yu C., Aggen, James B., Pitzen, Jennifer, Gliedt, Micah K., Semko, Chris M., Marquez, Abby, Evans, James W., Wang, Gang, Won, Walter S., Tomlinson, Aidan C. A., Kiss, Gert, Tzitzilonis, Christos, Thottumkara, Arun P., Cregg, James, Mellem, Kevin T., Choi, Jong S., Lee, Julie C., Zhao, Yongyuan, Lee, Bianca J., Meyerowitz, Justin G., Knox, John E., Jiang, Jingjing, Wang, Zhican, Wildes, David, Wang, Zhengping, Singh, Mallika, Smith, Jacqueline A. M., Gill, Adrian L.

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Discovery of (R)‑4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro‑1H‑pyrazolo[4,3‑c]quinoline (ELND006) and (R)‑4-Cyclopropyl-8-fluoro-5-(6-(trifluorome... by Probst, Gary, Aubele, Danielle L, Bowers, Simeon, Dressen, Darren, Garofalo, Albert W, Hom, Roy K, Konradi, Andrei W, Marugg, Jennifer L, Mattson, Matthew N, Neitzel, Martin L, Semko, Chris M, Sham, Hing L, Smith, Jenifer, Sun, Minghua, Truong, Anh P, Ye, Xiaocong M, Xu, Ying-zi, Dappen, Michael S, Jagodzinski, Jacek J, Keim, Pamela S, Peterson, Brian, Latimer, Lee H, Quincy, David, Wu, Jing, Goldbach, Erich, Ness, Daniel K, Quinn, Kevin P, Sauer, John-Michael, Wong, Karina, Zhang, Hongbin, Zmolek, Wes, Brigham, Elizabeth F, Kholodenko, Dora, Hu, Kang, Kwong, Grace T, Lee, Michael, Liao, Anna, Motter, Ruth N, Sacayon, Patricia, Santiago, Pamela, Willits, Christopher, Bard, Frédérique, Bova, Michael P, Hemphill, Susanna S, Nguyen, Lam, Ruslim, Lany, Tanaka, Kevin, Tanaka, Pearl, Wallace, William, Yednock, Ted A, Basi, Guriqbal S

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Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors by Truong, Anh P., Aubele, Danielle L., Probst, Gary D., Neitzel, Martin L., Semko, Chris M., Bowers, Simeon, Dressen, Darren, Hom, Roy K., Konradi, Andrei W., Sham, Hing L., Garofalo, Albert W., Keim, Pamela S., Wu, Jing, Dappen, Michael S., Wong, Karina, Goldbach, Erich, Quinn, Kevin P., Sauer, John-Michael, Brigham, Elizabeth F., Wallace, William, Nguyen, Lan, Hemphill, Susanna S., Bova, Michael P., Basi, Guriqbal

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Design, synthesis and structure–activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors by Aubele, Danielle L., Truong, Anh P., Dressen, Darren B., Probst, Gary D., Bowers, Simeon, Mattson, Matthew N., Semko, Chris M., Sun, Minghua, Garofalo, Albert W., Konradi, Andrei W., Sham, Hing L., Zmolek, Wes, Wong, Karina, Goldbach, Erich, Quinn, Kevin P., Sauer, John-Michael, Brigham, Elizabeth F., Wallace, William, Nguyen, Lan, Bova, Michael P., Hemphill, Susanna S., Basi, Guriqbal

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Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious γ-secretase inhibitors (Part II) by Ye, Xiaocong M., Konradi, Andrei W., Smith, Jenifer, Aubele, Danielle L., Garofalo, Albert W., Marugg, Jennifer, Neitzel, Marty L., Semko, Chris M., Sham, Hing L., Sun, Minghua, Truong, Anh P., Wu, Jing, Zhang, Hongbin, Goldbach, Erich, Sauer, John-Michael, Brigham, Elizabeth F., Bova, Michael, Basi, Guriqbal S.

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Abstract 4877: Allosteric inhibition of SHP2 variants containing cancer-associated activating mutations by Wildes, David, Aay, Naing, Buckl, Andreas, Hsieh, Daphne, Jogalekar, Ashutosh S., Kiss, Gert, Koltun, Elena S., Marquez, Abby, Mellem, Kevin T., Romero, Jason, Saldajeno-Concar, Mae, Schulze, Christopher J., Semko, Chris M., Won, Walter, Nichols, Robert J., Stahlhut, Carlos, Tzitzilonis, Christos, Gill, Adrian L., Smith, Jacqueline A.

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Abstract 4878: RMC-4550, an allosteric inhibitor of SHP2: Synthesis, structure, and anti-tumor activity by Koltun, Elena S., Aay, Naing, Buckl, Andreas, Jogalekar, Ashutosh S., Kiss, Gert, Marquez, Abby, Mellem, Kevin T., Mordec, Kasia, Saldajeno-Concar, Mae, Semko, Chris M., Tibrewal, Nidhi, Tzitzilonis, Christos, Won, Walter, Smith, Jacqueline A., Wilson, Susan E., Nichols, Robert J., Wang, Zhengping, Wilds, David, Singh, Mallika, Gill, Adrian L.

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Discovery of ( R )-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1 H -pyrazolo[4,3- c ]quinoline (ELND006) and ( R )-4-Cyclopropyl-8-fluoro-5-(6-(tri... by Probst, Gary, Aubele, Danielle L., Bowers, Simeon, Dressen, Darren, Garofalo, Albert W., Hom, Roy K., Konradi, Andrei W., Marugg, Jennifer L., Mattson, Matthew N., Neitzel, Martin L., Semko, Chris M., Sham, Hing L., Smith, Jenifer, Sun, Minghua, Truong, Anh P., Ye, Xiaocong M., Xu, Ying-zi, Dappen, Michael S., Jagodzinski, Jacek J., Keim, Pamela S., Peterson, Brian, Latimer, Lee H., Quincy, David, Wu, Jing, Goldbach, Erich, Ness, Daniel K., Quinn, Kevin P., Sauer, John-Michael, Wong, Karina, Zhang, Hongbin, Zmolek, Wes, Brigham, Elizabeth F., Kholodenko, Dora, Hu, Kang, Kwong, Grace T., Lee, Michael, Liao, Anna, Motter, Ruth N., Sacayon, Patricia, Santiago, Pamela, Willits, Christopher, Bard, Frédérique, Bova, Michael P., Hemphill, Susanna S., Nguyen, Lam, Ruslim, Lany, Tanaka, Kevin, Tanaka, Pearl, Wallace, William, Yednock, Ted A., Basi, Guriqbal S.

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A Label-Free Approach to Identify Inhibitors of α4β7-Mediated Cell Adhesion to MadCAM by Bova, Michael P., Nguyen, Lan, Wallace, William, Garrido, Caroline, Xu, Ying-Zi, Semko, Chris, Cockcroft, Kelly, Sandberg, Eric, Bard, Frederique

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Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent [gamma]-secretase inhibitors by Aubele, Danielle L, Truong, Anh P, Dressen, Darren B, Probst, Gary D, Bowers, Simeon, Mattson, Matthew N, Semko, Chris M, Sun, Minghua, Garofalo, Albert W, Konradi, Andrei W, Sham, Hing L, Zmolek, Wes, Wong, Karina, Goldbach, Erich, Quinn, Kevin P, Sauer, John-Michael, Brigham, Elizabeth F, Wallace, William, Nguyen, Lan, Bova, Michael P, Hemphill, Susanna S, Basi, Guriqbal

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Corrigendum to “Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors” [Bioorg. Med.... by Truong, Anh P., Aubele, Danielle L., Probst, Gary D., Neitzel, Martin L., Semko, Chris M., Bowers, Simeon, Dressen, Darren, Hom, Roy K., Konradi, Andrei W., Sham, Hing L., Garofalo, Albert W., Keim, Pamela S., Wu, Jing, Dappen, Michael S., Wong, Karina, Goldbach, Erich, Quinn, Kevin P., Sauer, John-Michael, Brigham, Elizabeth F., Wallace, William, Nguyen, Lan, Hemphill, Susanna S., Bova, Michael P., Bard, Frédérique, Yednock, Ted A., Basi, Guriqbal

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Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline g-secretase inhibitors by Truong, Anh P, Aubele, Danielle L, Probst, Gary D, Neitzel, Martin L, Semko, Chris M, Bowers, Simeon, Dressen, Darren, Hom, Roy K, Konradi, Andrei W, Sham, Hing L, Garofalo, Albert W, Keim, Pamela S, Wu, Jing, Dappen, Michael S, Wong, Karina, Goldbach, Erich, Quinn, Kevin P, Sauer, John-Michael, Brigham, Elizabeth F, Wallace, William, Nguyen, Lan, Hemphill, Susanna S, Bova, Michael P, Basi, Guriqbal

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Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline y-secretase inhibitors by TRUONG, Anh P, AUBELE, Danielle L, GAROFALO, Albert W, KEIM, Pamela S, JING WU, DAPPEN, Michael S, WONG, Marina, GOLDBACH, Erich, QUINN, Kevin P, SAUER, John-Michael, BRIGHAM, Elizabeth F, WALLACE, William, PROBST, Gary D, NGUYEN, Lan, HEMPHILL, Susanna S, BOVA, Michael P, BASI, Guriqbal, NEITZEL, Martin L, SEMKO, Chris M, BOWERS, Simeon, DRESSEN, Darren, HOM, Roy K, KONRADI, Andrei W, SHAM, Hing L

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Arylsulfonamide pyrimidines as VLA-4 antagonists by Xu, Ying-zi, Konradi, Andrei W., Bard, Frederique, Dappen, Michael, Dofiles, Lilibeth, Dreyer, Mark, Gallager, Ian, Garrido, Caroline, Krimm, Mike, Liao, Zhenmei, Messersmith, Elizabeth, Mutter, Linda, Pleiss, Michael A., Samant, Bhushan, Semko, Christopher M., Smith, Jennifer, Stappenbeck, Frank, Stupi, Brian, Vandervert, Chris, Welch, Brent, Wipke, Brian, Yednock, Ted

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