Rational Design, Synthesis, and SAR of a Novel Thiazolopyrimidinone Series of Selective PI3K-beta Inhibitors by Lin, Hong, Schulz, Mark J, Xie, Ren, Zeng, Jin, Luengo, Juan I, Squire, Michael D, Tedesco, Rosanna, Qu, Junya, Erhard, Karl, Mack, James F, Raha, Kaushik, Plant, Ramona, Rominger, Cynthia M, Ariazi, Jennifer L, Sherk, Christian S, Schaber, Michael D, McSurdy-Freed, Jeanelle, Spengler, Michael D, Davis, Charles B, Hardwicke, Mary Ann, Rivero, Ralph A

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Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin by Knight, Steven D, Adams, Nicholas D, Burgess, Joelle L, Chaudhari, Amita M, Darcy, Michael G, Donatelli, Carla A, Luengo, Juan I, Newlander, Ken A, Parrish, Cynthia A, Ridgers, Lance H, Sarpong, Martha A, Schmidt, Stanley J, Van Aller, Glenn S, Carson, Jeffrey D, Diamond, Melody A, Elkins, Patricia A, Gardiner, Christine M, Garver, Eric, Gilbert, Seth A, Gontarek, Richard R, Jackson, Jeffrey R, Kershner, Kevin L, Luo, Lusong, Raha, Kaushik, Sherk, Christian S, Sung, Chiu-Mei, Sutton, David, Tummino, Peter J, Wegrzyn, Ronald J, Auger, Kurt R, Dhanak, Dashyant

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Abstract 2919: Discovery of small-molecule compounds targeting c-MYC using a novel cell-based screen by Mangatt, Biju, Pietra, Anthony D., Waszkiewicz, Anna, Jaworski, Jon-Paul, Ghidelli-Disse, Sonja, Berrodin, Thomas J., Sherk, Christian S., Meinhold, Derrick W., Rutkowska-Klute, Anna, Sundaram, Shanker K., Ganji, Gopinath, Halsey, Wendy S., Livi, George P., Li, William, Mack, James, Romeril, Stuart P., Minthorn, Elisabeth A., Kumar, Rakesh, Drewes, Gerard C., Heerding, Dirk A., Kallal, Lorena A., Buser, Carolyn A., Medina, Jesus R.

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Abstract 2994: Discovery of selective, noncovalent small molecule inhibitors of DNMT1 as an alternative to traditional DNA hypomethylating agents by Pappalardi, Melissa B., Cockerill, Mark, Handler, Jessica L., Stowell, Alexandra, Keenan, Kathryn, Sherk, Christian S., Minthorn, Elisabeth A., McHugh, Charles F., Burt, Charlotte, Wong, Kristen, Fosbenner, David T., Patel, Mehul, Briand, Jacques, Mohammad, Helai, Rueda, Lourdes, Benowitz, Andrew, Prinjha, Rab, Heerding, Dirk, Kruger, Ryan G., Raoof, Ali, Jordan, Allan, King, Bryan W., McCabe, Michael T.

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Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin by Knight, Steven D., Adams, Nicholas D., Burgess, Joelle L., Chaudhari, Amita M., Darcy, Michael G., Donatelli, Carla A., Luengo, Juan I., Newlander, Ken A., Parrish, Cynthia A., Ridgers, Lance H., Sarpong, Martha A., Schmidt, Stanley J., Van Aller, Glenn S., Carson, Jeffrey D., Diamond, Melody A., Elkins, Patricia A., Gardiner, Christine M., Garver, Eric, Gilbert, Seth A., Gontarek, Richard R., Jackson, Jeffrey R., Kershner, Kevin L., Luo, Lusong, Raha, Kaushik, Sherk, Christian S., Sung, Chiu-Mei, Sutton, David, Tummino, Peter J., Wegrzyn, Ronald J., Auger, Kurt R., Dhanak, Dashyant

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Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell-Mediated Antitumor Immune Responses by Fedoriw, Andrew, Shi, Leilei, O'Brien, Shane, Smitheman, Kimberly N, Wang, Yunfei, Hou, Jiakai, Sherk, Christian, Rajapurkar, Satyajit, Laraio, Jenny, Williams, Leila J, Xu, Chunyu, Han, Guangchun, Feng, Qin, Bedford, Mark T, Wang, Linghua, Barbash, Olena, Kruger, Ryan G, Hwu, Patrick, Mohammad, Helai P, Peng, Weiyi

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Inhibition of FGF/FGFR autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230 by Blackwell, Christina, Sherk, Christian, Fricko, Maggie, Ganji, Gopinath, Barnette, Mary, Hoang, Bao, Tunstead, James, Skedzielewski, Tina, Alsaid, Hasan, Jucker, Beat M, Minthorn, Elisabeth, Kumar, Rakesh, DeYoung, M Phillip

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624 Targeting Type I arginine methyltransferases promotes T cell mediated antitumor immune responses by Shi, Leilei, Fedoriw, Andrew, O’Brien, Shane, Smitheman, Kimberly, Wang, Yunfei, Hou, Jiakai, Sherk, Christian, Rajapurkar, Satyajit, Laraio, Jenny, Williams, Leila, Xu, Chunyu, Han, Guangchun, Feng, Qin, Bedford, Mark, Wang, Linghua, Barbash, Olena, Kruger, Ryan, Hwu, Patrick, Mohammad, Helai, Peng, Weiyi

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Abstract LB-236: Preclinical efficacy of targeting FGF autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230 by Young, M. Phillip De, Sherk, Christian, Bleam, Maureen, Barnette, Mary, Ganji, Gopi, Hoang, Bao, Tunstead, James, Bellovin, David, Los, Gerrit, Minthorn, Elisabeth, Kumar, Rakesh

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Abstract 5418: Rapid LDH5 inhibition reverses malignant metabolic phenotype and impairs survival of hepatocellular carcinoma cells by Billiard, Julia, Annan, Roland, Ariazi, Jennifer, Briand, Jacques, Brown, Kristin, Campobasso, Nino, Chakravorty, Subhas, Chai, Deping, Colón, Mariela, Davenport, Elizabeth, Dodson, Christopher, Gaul, Nathan, Gilbert, Seth, Jurewicz, Anthony, Lu, Hong, McNulty, Dean, McSurdy-Freed, Jeanelle, Miller, Lisa, Nurse, Kelvin, Rao Nuthulaganti, Paru, Quinn, Chad, Schneck, Jessica, Scott, Gilbert, Shaw, Tony, Sherk, Christian, Smallwood, Angela, Sweitzer, Sharon, Villa, James, Waitt, Gregory, Wooster, Richard, Duffy, Kevin

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