Development of a highly sensitive liquid biopsy platform to detect clinically-relevant cancer mutations at low allele fractions in cell-free DNA by Gale, Davina, Lawson, Andrew R J, Howarth, Karen, Madi, Mikidache, Durham, Bradley, Smalley, Sarah, Calaway, John, Blais, Shannon, Jones, Greg, Clark, James, Dimitrov, Peter, Pugh, Michelle, Woodhouse, Samuel, Epstein, Michael, Fernandez-Gonzalez, Ana, Whale, Alexandra S, Huggett, Jim F, Foy, Carole A, Jones, Gerwyn M, Raveh-Amit, Hadas, Schmitt, Karin, Devonshire, Alison, Green, Emma, Forshew, Tim, Plagnol, Vincent, Rosenfeld, Nitzan

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Analytical validation of a next generation sequencing liquid biopsy assay for high sensitivity broad molecular profiling by Plagnol, Vincent, Woodhouse, Samuel, Howarth, Karen, Lensing, Stefanie, Smith, Matt, Epstein, Michael, Madi, Mikidache, Smalley, Sarah, Leroy, Catherine, Hinton, Jonathan, de Kievit, Frank, Musgrave-Brown, Esther, Herd, Colin, Baker-Neblett, Katherine, Brennan, Will, Dimitrov, Peter, Campbell, Nathan, Morris, Clive, Rosenfeld, Nitzan, Clark, James, Gale, Davina, Platt, Jamie, Calaway, John, Jones, Greg, Forshew, Tim

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The 3'-5' exoribonuclease Dis3 regulates the expression of specific microRNAs in Drosophila wing imaginal discs by Towler, Benjamin P, Jones, Christopher I, Viegas, Sandra C, Apura, Patricia, Waldron, Joseph A, Smalley, Sarah K, Arraiano, Cecilia M, Newbury, Sarah F

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A genomic approach to overcoming temozolomide resistance in glioblastoma multiforme by Smalley, Joshua L, Smalley, Sarah K, Zhang, Shu-Dong, Morley, Simon J, Gant, Timothy W

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Cancer Risks for BRCA1 and BRCA2 Mutation Carriers: Results From Prospective Analysis of EMBRACE by MAVADDAT, Nasim, PEOCK, Susan, DAVIDSON, Rosemarie, ECCLES, Diana, COLE, Trevor, COOK, Jackie, BREWER, Carole, TISCHKOWITZ, Marc, DOUGLAS, Fiona, HODGSON, Shirley, WALKER, Lisa, PORTEOUS, Mary E, FROST, Debra, MORRISON, Patrick J, SIDE, Lucy E, KENNEDY, M. John, HOUGHTON, Catherine, DONALDSON, Alan, ROGERS, Mark T, DORKINS, Huw, MIEDZYBRODZKA, Zosia, GREGORY, Helen, EASON, Jacqueline, ELLIS, Steve, BARWELL, Julian, MCCANN, Emma, MURRAY, Alex, ANTONIOU, Antonis C, EASTON, Douglas F, PLATTE, Radka, FINEBERG, Elena, EVANS, D. Gareth, IZATT, Louise, EELES, Rosalind A, ADLARD, Julian

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mTOR inhibition and levels of the DNA repair protein MGMT in T98G glioblastoma cells by Smalley, Sarah, Chalmers, Anthony J, Morley, Simon J

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Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers by Kuchenbaecker, Karoline B, Neuhausen, Susan L, Robson, Mark, Barrowdale, Daniel, McGuffog, Lesley, Mulligan, Anna Marie, Andrulis, Irene L, Spurdle, Amanda B, Schmidt, Marjanka K, Schmutzler, Rita K, Engel, Christoph, Wappenschmidt, Barbara, Nevanlinna, Heli, Thomassen, Mads, Southey, Melissa, Radice, Paolo, Ramus, Susan J, Domchek, Susan M, Nathanson, Katherine L, Lee, Andrew, Healey, Sue, Nussbaum, Robert L, Rebbeck, Timothy R, Arun, Banu K, James, Paul, Karlan, Beth Y, Lester, Jenny, Cass, Ilana, Terry, Mary Beth, Daly, Mary B, Goldgar, David E, Buys, Saundra S, Janavicius, Ramunas, Tihomirova, Laima, Tung, Nadine, Dorfling, Cecilia M, van Rensburg, Elizabeth J, Steele, Linda, v O Hansen, Thomas, Ejlertsen, Bent, Gerdes, Anne-Marie, Nielsen, Finn C, Dennis, Joe, Cunningham, Julie, Hart, Steven, Slager, Susan, Osorio, Ana, Benitez, Javier, Duran, Mercedes, Weitzel, Jeffrey N, Tafur, Isaac, Hander, Mary, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Roversi, Gaia, Scuvera, Giulietta, Bonanni, Bernardo, Mariani, Paolo, Volorio, Sara, Dolcetti, Riccardo, Varesco, Liliana, Papi, Laura, Tibiletti, Maria Grazia, Giannini, Giuseppe, Fostira, Florentia, Konstantopoulou, Irene, Garber, Judy, Hamann, Ute, Donaldson, Alan, Brewer, Carole, Foo, Claire, Evans, D Gareth, Frost, Debra, Eccles, Diana, Douglas, Fiona, Brady, Angela, Cook, Jackie, Tischkowitz, Marc, Adlard, Julian, Barwell, Julian, Ong, Kai-ren, Walker, Lisa, Izatt, Louise, Side, Lucy E, Kennedy, M John, Rogers, Mark T, Porteous, Mary E, Morrison, Patrick J, Platte, Radka, Eeles, Ros, Davidson, Rosemarie, Hodgson, Shirley, Ellis, Steve, Godwin, Andrew K, Rhiem, Kerstin, Meindl, Alfons, Ditsch, Nina, Arnold, Norbert, Plendl, Hansjoerg

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Abstract 939: Analytical validation of InVisionFirst™, a liquid biopsy assay for high-sensitivity broad molecular profiling of circulating tumor DNA using plasma samples of cancer... by Woodhouse, Samuel, Plagnol, Vincent, Howarth, Karen, Lensing, Stefanie, Smith, Matt, Epstein, Michael, Madi, Mikidache, Smalley, Sarah, Leroy, Catherine, Hinton, Jonathan, Kievit, Frank de, Musgrave-Brown, Esther, Herd, Colin, Baker-Neblett, Katherine, Brennan, Will, Dimitrov, Peter, Campbell, Nathan, Rosenfeld, Nitzan, Clark, James, Gale, Davina, Platt, Jamie, Calaway, John, Jones, Greg, Forshew, Tim

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Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers by Antoniou, Antonis C, Soucy, Penny, McGuffog, Lesley, Healey, Sue, Lee, Andrew, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Barile, Monica, Pasini, Barbara, Dolcetti, Riccardo, Giannini, Giuseppe, Varesco, Liliana, Radice, Paolo, Greene, Mark H., Glendon, Gord, Birk Jensen, Uffe, Crüger, Dorthe G., Caligo, Maria A., Laitman, Yael, Milgrom, Roni, Kaufman, Bella, Friedman, Eitan, Lindblom, Annika, Ehrencrona, Hans, Nathanson, Katherine L., Domchek, Susan M., Rebbeck, Timothy, Jakubowska, Ania, Gronwald, Jacek, Byrski, Tomasz, Cybulski, Cezary, Osorio, Ana, Ramón y Cajal, Teresa, Fostira, Florentia, Hogervorst, Frans B., Hooning, Maartje J., Meijers-Heijboer, Hanne E.J., Gómez Garcia, Encarna B., Peock, Susan, Platte, Radka, Lalloo, Fiona, Eeles, Ros, Davidson, Rosemarie, Eccles, Diana, Ong, Kai-ren, Cook, Jackie, Douglas, Fiona, Paterson, Joan, John Kennedy, M., Miedzybrodzka, Zosia, Godwin, Andrew, Stoppa-Lyonnet, Dominique, Buecher, Bruno, Tirapo, Carole, Barjhoux, Laure, Faivre, Laurence, Nogues, Catherine, Rouleau, Etienne, Pujol, Pascal, Coupier, Isabelle, Frénay, Marc, Daly, Mary B., John, Esther M., Singer, Christian F., Catharina Dressler, Anne, Offit, Kenneth, Rodriguez, Gustavo, Small, Laurie, Boggess, John, Blank, Stephanie, Basil, Jack, Ewart Toland, Amanda, Montagna, Marco, Tognazzo, Silvia, Blanco, Ignacio, Pharoah, Paul D.P., Karlan, Beth Y., Walsh, Christine S., Olah, Edith, Teo, Soo-Hwang, Beattie, Mary S., van Rensburg, Elizabeth J., Sluiter, Michelle D., Diez, Orland, Engel, Christoph, Meindl, Alfons, Ruehl, Ina, Varon-Mateeva, Raymonda, Niederacher, Dieter, Arnold, Norbert, Gadzicki, Dorothea, Caldes, Trinidad, de la Hoya, Miguel, Chen, Xiaoqing, Spurdle, Amanda B., Fredericksen, Zachary, Couch, Fergus, Simard, Jacques

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Abstract 3192: Liquid biopsies for molecular profiling of mutations in non-small cell lung cancer patients lacking tissue samples by Remon, Jordi, Soria, Jean Charles, Planchard, David, Jovelet, Cecile, Pannet, Chloe, Lacroix, Ludovic, Gazzah, Annas, Lawson, Andrew, Smalley, Sarah, Howarth, Kenth, Gale, David, Green, Emma, Plagnol, Vincent, Rosenfeld, Nitzan, Oulassen, Ken, Chaput, Nathalie, Besse, Benjamin

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Abstract 3639: Analytical performance and validation of an enhanced TAm-Seq circulating tumor DNA sequencing assay by Gale, Davina, Plagnol, Vincent, Lawson, Andrew, Pugh, Michelle, Smalley, Sarah, Howarth, Karen, Madi, Mikidache, Durham, Bradley, Kumanduri, Vasudev, Lo, Kitty, Clark, James, Green, Emma, Rosenfeld, Nitzan, Forshew, Tim

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Meaningful and Measurable Health Domains in Huntington’s Disease: Large-Scale Validation of the Huntington’s Disease Health-Related Quality of Life Questionnaire Across Severity St... by Ho, Aileen K., Landwehrmeyer, G. Bernhard, Rae, Daniela, Simpson, Sheila A., de Souza (Keylock), Jenny, Coulthard, Elizabeth, Gethin, Louise, Barker, Roger A., Fisher, Kate, Goodman, Anna, Hill, Susan, Swain, Rachel, Guzman, Natalie Valle, Callaghan, Jenny, Fullam, Ruth, Rosser, Anne, Tonner, Alison, Edwards, Maureen, Ho, Carrie, Pearson, Pauline, Foster, Jillian, McKenzie, Sue, Rothery, Jean, Deith, Catherine, Ireland, Jane, Harding, Alison, Laver, Fiona, Silva, Mark, Rowett, Liz, Musgrave, Hannah, Toscano, Jean, Gerrans, Emily, Anjum, Uruj, Coebergh, Jan, Eddy, Charlotte, Rose, Sarah, Andrews, Thomasin, Dougherty, Andrew, Golding, Charlotte, Lashwood, Alison, Ruddy, Deborah, Santhouse, Alastair, Whaite, Anna, Doherty, Karen, Haider, Salman, Robertson, Nicola, Tabrizi, Sarah, Taylor, Rachel, Bek, Judith, Craufurd, David, Johnson, Liz, Jones, Mary, Krishnamoorthy, Ashok, Oughton, Emma, Partington-Jones, Lucy, Westmoreland, Leann, Davidson, Lynn, Davison, Jill, Morgan, Karen, Savage, Lois, Wood, Josh, Siuda, Gill, Dixon, Kathryn, Armstrong, Richard, Burn, John, Weekes, Rebecca, Craven, Janet, Verstraelen (Ritchie), Nicola, Barrett, Wendy, Bandmann, Oliver, Fairtlough, Helen, Fillingham, Kay, Foustanos, Isabella, Gill, Paul, Kazoka, Mbombe, Peppa, Nadia, Quarrell, Oliver, Tidswell, Katherine, Gunner, Kerry, Harris, Kayla, Anderson, Mary, Keys, Liane, Smalley, Sarah, El-Nimr, George, Duffell, Allison, Kennedy (nee Smith), Karen, Bucher, Walter, de Schepper, Beatrice, Eden, John, Hendrikx, Victor, King, Diana, Lenon-Bird, Anne, Rapaille, Lilliane, Santini, Helen, Sasinkova, Pavla, Soltysiak, Beverley, Smith, Steve, van der Leer, Hans, van der Meer, Lucienne, Wooldridge, Michael

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Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of B... by Mulligan, Anna Marie, Couch, Fergus J, Barrowdale, Daniel, Domchek, Susan M, Eccles, Diana, Nevanlinna, Heli, Ramus, Susan J, Robson, Mark, Sherman, Mark, Spurdle, Amanda B, Wappenschmidt, Barbara, Lee, Andrew, McGuffog, Lesley, Healey, Sue, Sinilnikova, Olga M, Janavicius, Ramunas, Hansen, Thomas vO, Nielsen, Finn C, Ejlertsen, Bent, Osorio, Ana, Muñoz-Repeto, Iván, Durán, Mercedes, Godino, Javier, Pertesi, Maroulio, Benítez, Javier, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Cattaneo, Elisa, Bonanni, Bernardo, Viel, Alessandra, Pasini, Barbara, Papi, Laura, Ottini, Laura, Savarese, Antonella, Bernard, Loris, Radice, Paolo, Hamann, Ute, Verheus, Martijn, Meijers-Heijboer, Hanne E J, Wijnen, Juul, Gómez García, Encarna B, Nelen, Marcel R, Kets, C Marleen, Seynaeve, Caroline, Tilanus-Linthorst, Madeleine M A, van der Luijt, Rob B, van Os, Theo, Rookus, Matti, Frost, Debra, Jones, J Louise, Evans, D Gareth, Lalloo, Fiona, Eeles, Ros, Izatt, Louise, Adlard, Julian, Davidson, Rosemarie, Cook, Jackie, Donaldson, Alan, Dorkins, Huw, Gregory, Helen, Eason, Jacqueline, Houghton, Catherine, Barwell, Julian, Side, Lucy E, McCann, Emma, Murray, Alex, Peock, Susan, Godwin, Andrew K, Schmutzler, Rita K, Rhiem, Kerstin, Engel, Christoph, Meindl, Alfons, Ruehl, Ina, Arnold, Norbert, Niederacher, Dieter, Sutter, Christian, Deissler, Helmut, Gadzicki, Dorothea, Kast, Karin, Preisler-Adams, Sabine, Varon-Mateeva, Raymonda, Schoenbuchner, Ines, Fiebig, Britta, Heinritz, Wolfram, Schäfer, Dieter, Gevensleben, Heidrun, Caux-Moncoutier, Virginie, Fassy-Colcombet, Marion, Cornelis, François, Mazoyer, Sylvie, Léoné, Mélanie, Boutry-Kryza, Nadia, Hardouin, Agnès, Berthet, Pascaline, Muller, Danièle, Fricker, Jean-Pierre, Mortemousque, Isabelle, Pujol, Pascal

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P3.02b-102 Osimertinib Benefit in ctDNA T790M Positive, EGFR-Mutant NSCLC Patients by Remon, Jordi, Caramella, Caroline, Joelet, Cecile, Lacroix, Ludovic, Lawson, Andrew, Smalley, Sarah, Howarth, Karen, Gale, Davina, Rosenfeld, Nitzan, Green, Emma, Plagnol, Vincent, Planchard, David, Bluthgen, Maria, Gazzah, Annas, Pannet, Chloe, Nicotra, Claudio, Soria, Jean-Charles, Besse, Benjamin

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P2.03b-093 Validation and Performance of a Standardized ctDNA NGS Assay across Two Laboratories by Forshew, Tim, Lawson, Andrew, Smalley, Sarah, Plagnol, Vincent, Calaway, John, Blais, Shannon, Howarth, Karen, Jones, Greg, Pugh, Michelle, Madi, Mikidachi, Durham, Bradley, Musgrave-Brown, Esther, Woodhouse, Sam, Rosenfeld, Nitzan, Gale, Davina, Green, Emma, Clark, James

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P3.02b-102 Osimertinib Benefit in ctDNA T790M Positive, EGFR-Mutant NSCLC Patients: Topic: EGFR RES by Remon, Jordi, Caramella, Caroline, Joelet, Cecile, Lacroix, Ludovic, Lawson, Andrew, Smalley, Sarah, Howarth, Karen, Gale, Davina, Rosenfeld, Nitzan, Green, Emma, Plagnol, Vincent, Planchard, David, Bluthgen, Maria, Gazzah, Annas, Pannet, Chloe, Nicotra, Claudio, Soria, Jean-Charles, Besse, Benjamin

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P2.03b-093 Validation and Performance of a Standardized ctDNA NGS Assay across Two Laboratories: Topic: Biomarkers by Forshew, Tim, Lawson, Andrew, Smalley, Sarah, Plagnol, Vincent, Calaway, John, Blais, Shannon, Howarth, Karen, Jones, Greg, Pugh, Michelle, Madi, Mikidachi, Durham, Bradley, Musgrave-Brown, Esther, Woodhouse, Sam, Rosenfeld, Nitzan, Gale, Davina, Green, Emma, Clark, James

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Abstract B7: Assessing the clinical applications of ctDNA in patients with advanced stage metastatic cancer using our enhanced TAm-Seq platform by Smalley, Sarah K., Gale, Davina, Lawson, Andrew RJ, Remon-Masip, Jordi, Perez, Esperanza, Pugh, Michelle, Howarth, Karen, Touat, Mehdi, Soria, Jean-Charles, Hollebecque, Antoine, Besse, Benjamin, Forshew, Tim, Plagnol, Vincent, Lacroix, Ludovic, Rosenfeld, Nitzan

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Liquid biopsies could be superior to tumor biopsy to provide a molecular profile in non-small cell lung cancer (NSCLC) patients by Remon, Jordi, Lacroix, Ludovic, Planchard, David, Pannet, Chloe, Jovelet, Cecile, Lawson, Andrew, Smalley, Sarah, Howarth, Kevin, Gale, David, Green, Emma, Plagnol, Vincent, Rosenfeld, Nicolas, Soria, Jean-Charles, Besse, Benjamin

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Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study by Jakubowska, A, Rozkrut, D, Hamann, U, Scott, R J, McGuffog, L, Healy, S, Sinilnikova, O M, Rennert, G, Lejbkowicz, F, Flugelman, A, Andrulis, I L, Glendon, G, Ozcelik, H, Thomassen, M, Paligo, M, Kantala, J, Aroer, B, von Wachenfeldt, A, Loman, N, Herbst, K, Kristoffersson, U, Rosenquist, R, Karlsson, P, Stenmark-Askmalm, M, Melin, B, Nathanson, K L, Domchek, S M, Byrski, T, Huzarski, T, Gronwald, J, Menkiszak, J, Cybulski, C, Serrano, P, Cajal, T R, Tsitlaidou, M, Benítez, J, Rookus, M, Kluijt, I, Boessenkool-Pape, J L, Meijers-Heijboer, H E J, Oosterwijk, J C, van Asperen, C J, Nelen, M R, van den Ouweland, A M W, Seynaeve, C, Easton, D F, Frost, D, Platte, R, Ellis, S D, Fineberg, E, Evans, D G, Lalloo, F, Eeles, R, Jacobs, C, Adlard, J, Davidson, R, Eccles, D, Cole, T, Cook, J, Godwin, A, Bove, B, Stoppa-Lyonnet, D, Caux-Moncoutier, V, Belotti, M, Tirapo, C, Barjhoux, L, Pujol, P, Coupier, I, Peyrat, J-P, Vennin, P, Fricker, J-P, Venat-Bouvet, L, Johannsson, O Th, Isaacs, C, Schmutzler, R, Wappenschmidt, B, Meindl, A, Arnold, N, Varon-Mateeva, R, Niederacher, D, Sutter, C, Deissler, H, Preisler-Adams, S, Simard, J, Durocher, F, Beesley, J, Chen, X, Rebbeck, T, Couch, F, Wang, X, Lindor, N, Fredericksen, Z, Pankratz, V S, Peterlongo, P, Bonanni, B, Fortuzzi, S, Peissel, B, Szabo, C, Mai, P L, Loud, J T

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